Resistance Exercise Volume and Hypertrophic Response Variability in Elderly

NCT06718712 | Completed

• 1 other identifier: 62590416.0.0000.5391
• Study Type: interventional
• Target: 102
• Locations: 1 country
• Sites: 1

Brief Summary

The study aimed to investigate the effects of resistance training volume manipulation on whole muscle hypertrophy among non-responders and responders to a low resistance training dose (single-set).

Conditions

Aging; Muscle Hypertrophy

Keywords

aging; muscle mass; muscle strength; resistance exercise; sets

Outcome Measures

Primary Outcomes (1)

• Quadriceps muscle cross-sectional area

  Quadriceps muscle CSA was obtained through magnetic resonance imaging.

  10 weeks

Secondary Outcomes (1)

• Maximum dynamic strength

  10 weeks

Other Outcomes (7)

• Dietary assessment

  Before intervention

• Mass spectrometry

  10 weeks

• Skeletal muscle RNA-sequencing

  10 weeks

Study Arms (2)

Single set

EXPERIMENTAL

One set of unilateral knee-extension exercise of 8-15 RM with a 60-90 s interval.

Other: Lower body resistance training

Four sets

EXPERIMENTAL

Four sets of unilateral knee-extension exercise of 8-15 RM with a 60-90 s interval between sets.

Other: Lower body resistance training

Interventions

Lower body resistance training OTHER

The RT protocol was performed using a unilateral knee-extension machine. To reduce potential sources of bias to exercise order, subjects alternated the starting leg for each training session.

Four sets; Single set

Eligibility Criteria

• Age: 60 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• years and older
• not engaged in regular resistance and/or aerobic training for at least six months before the intervention

You may not qualify if:

• diagnosed type I diabetes mellitus
• arrhythmia
• noncontrolled hypertension
• any major orthopedic musculoskeletal condition
• use of any dietary supplement or drug with potential anabolic effects

Sponsors & Collaborators

• University of Sao Paulo General Hospital: lead
• University of Sao Paulo: collaborator

Study Sites (1)

University of Sao Paulo

São Paulo, São Paulo, 05508-030, Brazil

Location

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: OUTCOMES ASSESSOR
• Purpose: OTHER
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Model Details: Lower body unilateral design

Study Record Dates

• First Submitted: December 1, 2024
• First Posted: December 5, 2024
• Study Start: April 1, 2018
• Primary Completion: December 20, 2018
• Study Completion: December 20, 2018
• Last Updated: December 11, 2024

Record last verified: 2024-11

Data Sharing

• IPD Sharing: Will not share

Locations

BR (1)