Analyzing Acoustic Properties of the Vowel "a" Collected Via Mobile Phone From Individuals Diagnosed With Chronic Obstructive Pulmonary Disease and Health Control Groups

NCT06705647 | Active Not Recruiting DMC

• 1 other identifier: BTH-6.1.1-0198-2024
• Study Type: observational
• Target: 48
• Locations: 1 country
• Sites: 1

Brief Summary

The Study aims to identify the changes in voice caused by Chronic Obstructive Pulmonary Disease (COPD) statistically for identifying the potential digital voice biomarkers.

Conditions

Chronic Obstructive Pulmonary Disease

Keywords

Acoustic features; Statistic analysis; Mel frequency cepstral coefficients; Vowel quadrilateral

Outcome Measures

Primary Outcomes (1)

• Difference in Acoustic Voice Features Between COPD and Healthy Control Participants Difference in Acoustic Voice Features Between COPD and Healthy Control Participants

  This study assesses differences in baseline acoustic features (e.g., F0, HNR, jitter, shimmer, and formant frequencies), MFCC features (1-13 and derivatives Δ, ΔΔ), and vowel quadrilateral metrics (VSA from F1 and F2 of the sustained vowel 'a') between COPD and healthy controls. Acoustic features are extracted using Parselmouth and Praat, while MFCC features are computed with Librosa. Descriptive statistics (median, mean, std) are calculated, and group differences are tested for significance using the Mann-Whitney U test. Units include median, mean, std for each feature and VSA (Hertz²). Results will include p-values for group comparisons.

  30 weeks

Study Arms (2)

COPD

24 COPD participants, 12 Female and 12 Male.

Other: Chronic Obstructive Pulmonary Disease (COPD)

HC

24 HC participants, 12 Female and 12 Male.

Other: Chronic Obstructive Pulmonary Disease (COPD)

Interventions

Chronic Obstructive Pulmonary Disease (COPD) OTHER

The base line acoustic and mel frequency ceprtum coefficients will be analysed statistically between COPD voices and healthy control groups to highlight the correlation between COPD and its effects on voice production.

Also known as: Healthy Control (HC)

COPD; HC

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Data collected from participants 18 years old and older with and without COPD diagnosis will be used. The participants will be balanced on a gender and age basis.

You may qualify if:

• being 18 years old and older.

You may not qualify if:

• being under 18 years old and older.

Sponsors & Collaborators

• Blekinge Institute of Technology: lead
• Excellence Center at Linköping - Lund in Information Technology (ELLIIT): collaborator

Study Sites (1)

Blekinge Institute of Technology

Karlskrona, Blekinge County, 37179, Sweden

Location

Related Publications (1)

• Idrisoglu A, Moraes ALD, Cheddad A, Anderberg P, Whitling S, Jakobsson A, Berglund JS. Feature Analysis of the Vowel [a:] in Individuals With Chronic Obstructive Pulmonary Disease and Healthy Controls. J Voice. 2025 Oct 29:S0892-1997(25)00429-1. doi: 10.1016/j.jvoice.2025.10.013. Online ahead of print.

  PMID: 41168019 DERIVED

MeSH Terms

Conditions

Pulmonary Disease, Chronic Obstructive

Condition Hierarchy (Ancestors)

Lung Diseases, Obstructive; Lung Diseases; Respiratory Tract Diseases; Chronic Disease; Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: November 22, 2024
• First Posted: November 26, 2024
• Study Start: October 28, 2024
• Primary Completion: February 28, 2025
• Study Completion: March 30, 2025
• Last Updated: November 26, 2024

Record last verified: 2024-11

Data Sharing

• IPD Sharing: Will not share

Locations

SE (1)