Clinical Presentation and Outcome of COPD Patients With Acute Exacerbation Attending Sohag University Hospital

NCT06684353 | Not Yet Recruiting

• 1 other identifier: Soh-Med-24-09-15MS
• Study Type: observational
• Target: 200
• Locations: 0 countries
• Sites: N/A

Brief Summary

Chronic obstructive pulmonary disease (COPD) is a worldwide public health challenge because of high prevalence and related disability and mortality (1). Acute exacerbation of COPD (AECOPD), defned as the worsening of respiratory symptoms and requirement of additional clinical treatment, it reduces lung function and quality of life, and is accompanied by an increased disease-related burden, high hospital mortality and poor outcome (2). Chronic obstructive pulmonary disease frequently coexists with other chronic diseases, namely comorbidities. They negatively impact prognosis, exacerbations and quality of life in COPD patients. Local and systemic inflammation have been proposed as having a potential role in explaining the association between COPD and these comorbidities (3).

Conditions

Chronic Obstructive Pulmonary Disease

Outcome Measures

Primary Outcomes (1)

• Clinical Presentation and Outcome of COPD Patients With Acute Exacerbation Attending Sohag University Hospital

  Detection which patient with COPD exacerbation has more risk of survival or mortality

  1 year

Study Arms (2)

COPD patients in ICU with high risk of mortality (non survivors)

COPD patients on NIV / MV

COPD patients in ICU with low risk of mortality ( survivors )

COPD patients on NIV / MV

Eligibility Criteria

• Age: 18 Years - 90 Years
• Sex: all
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

patients aged more than 18 years with a confirmed COPD diagnosis according to (GOLD) guidelines, presented with acute exacerbation

You may qualify if:

• patients with a confirmed COPD diagnosis according to (GOLD) guidelines, presented with acute exacerbation

You may not qualify if:

• Stable COPD
• Any other chronic chest diseases; Bronchial asthma or bronchiectasis

Sponsors & Collaborators

• Sohag University: lead

Related Publications (5)

• Fabbri LM, Boschetto P, Mapp CE; Global Initiative for Chronic Obstructive Lung Disease; Global Initiative for Asthma Management and Prevention. COPD guidelines: the important thing is not to stop questioning. Am J Respir Crit Care Med. 2007 Sep 15;176(6):527-8. doi: 10.1164/rccm.200706-854ED. No abstract available.

  PMID: 17823358 BACKGROUND

• Bateman ED, Feldman C, O'Brien J, Plit M, Joubert JR; COPD Guideline Working Group of the South African Thoracic Society. Guideline for the management of chronic obstructive pulmonary disease (COPD): 2004 revision. S Afr Med J. 2004 Jul;94(7 Pt 2):559-75.

  PMID: 15283307 BACKGROUND

• Corrections. Lancet Respir Med. 2017 Oct;5(10):e30. doi: 10.1016/S2213-2600(17)30336-3. Epub 2017 Sep 14. No abstract available.

  PMID: 28918970 BACKGROUND

• Nakai T, Ueda M, Takeda R. Effects of calcium and magnesium ions on the interaction of corticosterone with rat brain cytosol receptor(s). Endocr Res Commun. 1978;5(2):81-90. doi: 10.3109/07435807809089010.

  PMID: 102509 BACKGROUND

• Hand D. National Boards lose control of funding. Nurs Stand. 1991 Feb 13-19;5(21):20. No abstract available.

  PMID: 1900164 BACKGROUND

MeSH Terms

Conditions

Pulmonary Disease, Chronic Obstructive

Condition Hierarchy (Ancestors)

Lung Diseases, Obstructive; Lung Diseases; Respiratory Tract Diseases; Chronic Disease; Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Central Study Contacts

Mona A Hussien, Resident doctor

CONTACT

01152232471; mona_abdelaleem_post@med.sohag.edu.eg

Hamdy A Mohammaden, Professor doctor

CONTACT

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Resident doctor at chest department Sohag University Hospital

Study Record Dates

• First Submitted: November 10, 2024
• First Posted: November 12, 2024
• Study Start: November 30, 2024
• Primary Completion: November 3, 2025
• Study Completion: November 3, 2025
• Last Updated: November 15, 2024

Record last verified: 2024-10