The Use of Statin in Diabetic Patients Not Known to Have Atherosclerotic Cardiovascular Disease

NCT06676683 | Not Yet Recruiting

• 1 other identifier: Statin in diabetic patient
• Study Type: observational
• Target: 300
• Locations: 1 country
• Sites: 1

Brief Summary

the use of Statin in diabetic patients and its correlation to the guidelines recommendation.

Conditions

Diabete Type 2

Keywords

Statin - diabetic - Atherosclerotic cardiovascular disease

Outcome Measures

Primary Outcomes (1)

• changes in lipid profile in response to treatment with statin in diabetc patients

  Guidelines endorse statin use in Type 2 Diabetes Mellitus (T2DM) to mitigate cardiovascular risks and mortality.

  12 Weeks

Interventions

Usage of Statin in diabetic patients DRUG

The use of statin in diabetic patients not known to have Atherosclerotic cardiovascular disease in a low income community

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Use of Statin in diabetic patients and its correlation to the guidelines recommendation.

You may qualify if:

• All diabetic \> 18 years.

You may not qualify if:

• Diabetic Patients with known to have Atherosclerotic cardiovascular disease.

Sponsors & Collaborators

• Sohag University: lead

Study Sites (1)

Sohag university hospital

Sohag, 82524, Egypt

Location

Related Publications (12)

• Farmer JA. Diabetic dyslipidemia and atherosclerosis: evidence from clinical trials. Curr Diab Rep. 2008 Feb;8(1):71-7. doi: 10.1007/s11892-008-0013-2.

  PMID: 18367002 BACKGROUND

• de Vries FM, Denig P, Pouwels KB, Postma MJ, Hak E. Primary prevention of major cardiovascular and cerebrovascular events with statins in diabetic patients: a meta-analysis. Drugs. 2012 Dec 24;72(18):2365-73. doi: 10.2165/11638240-000000000-00000.

  PMID: 23186103 BACKGROUND

• Kurihara O, Thondapu V, Kim HO, Russo M, Sugiyama T, Yamamoto E, Fracassi F, Minami Y, Wang Z, Lee H, Yonetsu T, Jang IK. Comparison of Vascular Response to Statin Therapy in Patients With Versus Without Diabetes Mellitus. Am J Cardiol. 2019 May 15;123(10):1559-1564. doi: 10.1016/j.amjcard.2019.02.020. Epub 2019 Feb 22.

  PMID: 30851939 BACKGROUND

• Almeida SO, Budoff M. Effect of statins on atherosclerotic plaque. Trends Cardiovasc Med. 2019 Nov;29(8):451-455. doi: 10.1016/j.tcm.2019.01.001. Epub 2019 Jan 7.

  PMID: 30642643 BACKGROUND

• Arnett DK, Blumenthal RS, Albert MA, Buroker AB, Goldberger ZD, Hahn EJ, Himmelfarb CD, Khera A, Lloyd-Jones D, McEvoy JW, Michos ED, Miedema MD, Munoz D, Smith SC Jr, Virani SS, Williams KA Sr, Yeboah J, Ziaeian B. 2019 ACC/AHA Guideline on the Primary Prevention of Cardiovascular Disease: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines. Circulation. 2019 Sep 10;140(11):e596-e646. doi: 10.1161/CIR.0000000000000678. Epub 2019 Mar 17. No abstract available.

  PMID: 30879355 BACKGROUND

• Addendum. 10. Cardiovascular Disease and Risk Management: Standards of Medical Care in Diabetes-2021. Diabetes Care 2021;44(Suppl. 1):S125-S150. Diabetes Care. 2021 Sep;44(9):2183-2185. doi: 10.2337/dc21-ad09a. Epub 2021 Jun 16. No abstract available.

  PMID: 34135017 BACKGROUND

• Ogasawara K, Mashiba S, Hashimoto H, Kojima S, Matsuno S, Takeya M, Uchida K, Yajima J. Low-density lipoprotein (LDL), which includes apolipoprotein A-I (apoAI-LDL) as a novel marker of coronary artery disease. Clin Chim Acta. 2008 Nov;397(1-2):42-7. doi: 10.1016/j.cca.2008.07.014. Epub 2008 Jul 18.

  PMID: 18691566 BACKGROUND

• Taylor F, Huffman MD, Macedo AF, Moore TH, Burke M, Davey Smith G, Ward K, Ebrahim S. Statins for the primary prevention of cardiovascular disease. Cochrane Database Syst Rev. 2013 Jan 31;2013(1):CD004816. doi: 10.1002/14651858.CD004816.pub5.

  PMID: 23440795 BACKGROUND

• Carter AA, Gomes T, Camacho X, Juurlink DN, Shah BR, Mamdani MM. Risk of incident diabetes among patients treated with statins: population based study. BMJ. 2013 May 23;346:f2610. doi: 10.1136/bmj.f2610.

  PMID: 23704171 BACKGROUND

• Jellinger PS, Handelsman Y, Rosenblit PD, Bloomgarden ZT, Fonseca VA, Garber AJ, Grunberger G, Guerin CK, Bell DSH, Mechanick JI, Pessah-Pollack R, Wyne K, Smith D, Brinton EA, Fazio S, Davidson M. AMERICAN ASSOCIATION OF CLINICAL ENDOCRINOLOGISTS AND AMERICAN COLLEGE OF ENDOCRINOLOGY GUIDELINES FOR MANAGEMENT OF DYSLIPIDEMIA AND PREVENTION OF CARDIOVASCULAR DISEASE. Endocr Pract. 2017 Apr;23(Suppl 2):1-87. doi: 10.4158/EP171764.APPGL.

  PMID: 28437620 BACKGROUND

• Mach F, Baigent C, Catapano AL, Koskinas KC, Casula M, Badimon L, Chapman MJ, De Backer GG, Delgado V, Ference BA, Graham IM, Halliday A, Landmesser U, Mihaylova B, Pedersen TR, Riccardi G, Richter DJ, Sabatine MS, Taskinen MR, Tokgozoglu L, Wiklund O; ESC Scientific Document Group. 2019 ESC/EAS Guidelines for the management of dyslipidaemias: lipid modification to reduce cardiovascular risk. Eur Heart J. 2020 Jan 1;41(1):111-188. doi: 10.1093/eurheartj/ehz455. No abstract available.

  PMID: 31504418 BACKGROUND

• Rodriguez F, Maron DJ, Knowles JW, Virani SS, Lin S, Heidenreich PA. Association Between Intensity of Statin Therapy and Mortality in Patients With Atherosclerotic Cardiovascular Disease. JAMA Cardiol. 2017 Jan 1;2(1):47-54. doi: 10.1001/jamacardio.2016.4052.

  PMID: 27829091 BACKGROUND

MeSH Terms

Conditions

Diabetes Mellitus, Type 2

Condition Hierarchy (Ancestors)

Diabetes Mellitus; Glucose Metabolism Disorders; Metabolic Diseases; Nutritional and Metabolic Diseases; Endocrine System Diseases

Central Study Contacts

Islam A Hassan, Master

CONTACT

00201033799510; islam_abdelaziz_post@med.sohag.edu.eg

Usama M Abdelaal, Professor

CONTACT

00201065962094

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Doctor

Study Record Dates

• First Submitted: November 1, 2024
• First Posted: November 6, 2024
• Study Start: December 1, 2024
• Primary Completion: November 1, 2025
• Study Completion: December 1, 2025
• Last Updated: November 6, 2024

Record last verified: 2024-11

Locations

EG (1)