Muslce Oxygenation of the Quadricep Relative to Angle and Load

NCT06638788 | Not Yet Recruiting

• 1 other identifier: H24-01632
• Study Type: interventional
• Target: 20
• Locations: 0 countries
• Sites: N/A

Brief Summary

The purpose of the present study is to determine if the amount of oxygen in muscles during resistance exercise with different weights is related to changes in torque or knee joint angle. Participants will need to come to the lab three times over three weeks. On their first visit, we will test how strong their muscles are by testing the maximal weight that can be lifted in a single repetition of a knee extension referred to as a 1 repetition maximal (1RM) followed by exercise interventions during the second and third weeks. Each exercise session will have participants lift different amounts of weight. They will use two machines: the Biodex dynamometer, that maintains constant force during a knee extension and a standard weighted knee extension machine which has variable force outputs. Participants will perform these exercises against three levels of weight, making six tests in total. Their first exercise session will take about 70 minutes and the following sessions around 55-60 minutes. They will be provided a 5-minute break between each set of lifts to ensure they are fully rested. In total, participants will be exercising for about 25-30 minutes each visit, with the rest of the time spent resting. The weights will be different percentages of the heaviest weight participants can lift.

Conditions

Healthy

Keywords

Muscle Oxygenation; Angle and Muscle Oxygenation; Torque and muscle oxygenation; Knee extension and muscle oxygenation

Outcome Measures

Primary Outcomes (2)

• Muscle oxygenation (SmO2) curve during constant torque knee extension compared to joint angle

  Percent of SmO2 dynamic range (%SmO2 max) will be measured during constant torque knee extension conditions at 20, 40, and 60% 1RM at 18, 12, and 6 reps respectively. The SmO2 curve for each sextile of the reps range of motion will be compared to joint angle across the three loads.

  Within 55/60mins testing session during week 2 or 3.

• Muscle oxygenation (SmO2) curve during variable torque knee extension compared to torque

  Percent of SmO2 dynamic range (%SmO2 max) will be measured during variable torque knee extension conditions at 20, 40, and 60% 1RM at 18, 12, and 6 reps respectively. The SmO2 curve for each sextile of the reps range of motion will be compared to torque across the three loads.

  Within 55/60mins testing session during week 2 or 3.

Secondary Outcomes (1)

• Muscle oxygenation curve during variable torque compared to constant torque

  Within 55/60mins testing session during week 2 or 3.

Other Outcomes (6)

• Rate of muscle deoxygenation (%SmO2 max) compared to load for constant torque knee extension

  Within 55/60mins testing session during week 2 or 3.

• Rate of muscle deoxygenation (%SmO2 max) compared to load for variable torque knee extension

  Within 55/60mins testing session during week 2 or 3.

• Muscle oxygenation slope during eccentric compared to concentric muscle contraction in variable and constant torque knee extension

  Within 55/60mins testing session during week 2 or 3.

Study Arms (2)

Constant Torque Biodex Dynamometer

EXPERIMENTAL

Participants will perform their intervention on the constant torque Biodex Dynamometer

Other: Knee extension

Variable Torque Standerd Knee Extension

EXPERIMENTAL

Participants will perform their intervention on the variable torque standerd knee extension machine

Other: Knee extension

Interventions

Knee extension OTHER

Participants will perform 20, 40, and 60% of thier 1 rep maximum (1RM) at 18, 12, and 6 reps respectively.

Constant Torque Biodex Dynamometer; Variable Torque Standerd Knee Extension

Eligibility Criteria

• Age: 19 Years - 30 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Able to understand and communicate in English
• All "No" answers on the CSEP Get Active questionnaire

You may not qualify if:

• Current use of cigarettes or other nicotine devices
• Any major uncontrolled cardiovascular, muscular, metabolic, and/or neurological disorders
• Any medical condition impacting the ability to participate in maximal exercise
• Type one or type two diabetes
• Diagnosis of cancer or undergoing cancer treatment in the past 12 months
• Drug therapy with any drugs that alter skeletal muscle metabolism (i.e., Metformin, Benzodiazepines, hormone replacement therapy drugs)

Sponsors & Collaborators

• University of British Columbia: lead

Study Officials

• Cameron Mitchell, B.kin, MSc, PhD

  University of British Columbia

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Cameron Mitchell, B.kin, MSc, PhD

CONTACT

604-827-2072; cameron.mitchell@ubc.ca

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assistant Professor

Model Details: Participants will be completing loads of 20, 40, and 60% 1RM at 18,12, and 6 reps respectively on the standard knee extension (varying torque) and biodex dynamometer machine (constant torque). The muscle oxygenation of the vastus laterals muscle will be assessed throughout its range of motion in both conditions and compared to torque (standard knee extension) or knee angle (Biodex dynamometer).

Study Record Dates

• First Submitted: October 10, 2024
• First Posted: October 15, 2024
• Study Start: September 30, 2024
• Primary Completion: November 1, 2024
• Study Completion: November 1, 2024
• Last Updated: October 15, 2024

Record last verified: 2024-09