The Effects of Intensity on Exercise-Induced Hypoalgesia During a Knee Extension Exercise

NCT05561582 | Completed Results

• 1 other identifier: 3
• Study Type: interventional
• Target: 60
• Locations: 1 country
• Sites: 1

Brief Summary

The primary purpose of this study is to to compare immediate changes in pressure pain threshold at the exercising muscle (quadriceps) and a non-exercising muscle (upper trapezius) during low and high weight knee extension exercise. Participants will attend one session that consists of pain sensitivity testing, completion of pain-related psychological questionnaires, and random assignment to one of three interventions: 1) knee extension exercise with a high weight, 2) knee extension exercise with a low weight, or 3) quiet rest.

Conditions

Healthy

Outcome Measures

Primary Outcomes (1)

• Pressure Pain Threshold

  A digital pressure algometer will be applied to the quadriceps and upper trapezius for two trials each. Participants are instructed to say "stop" or "pain" so the stimulus can be terminated "when the sensation first transitions from pressure to pain" (pain threshold). Participants will rate the pain experienced during the threshold testing using a 101-point numeric pain rate scale (NPRS) anchored with 0= no pain to 100= the most intense pain sensation imaginable immediately following each testing time.

  1 day

Secondary Outcomes (1)

• Conditioned Pain Modulation

  1 day

Study Arms (3)

High Intensity Exercise

EXPERIMENTAL

Participants will complete a knee extension exercise with weight equivalent to 75% of their 1-repetition maximum for 3 sets of 10 repetitions.

Other: Seated knee extension exercise

Low Intensity Exercise

EXPERIMENTAL

Participants will complete a knee extension exercise with weight equivalent to 30% of their 1-repetition maximum for 3 sets of 10 repetitions.

Other: Seated knee extension exercise

Quiet Rest

NO INTERVENTION

Participants will sit quietly for two minutes, three times.

Interventions

Seated knee extension exercise OTHER

Participants will be seated in a resistance exercise machine. Weight corresponding to the assigned group will be added to the machine. Participants will extend the dominant knee for 3 sets of 10 repetitions.

High Intensity Exercise; Low Intensity Exercise

Eligibility Criteria

• Age: 18 Years - 60 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Pain-free
• years old
• Participant can appropriately perform the knee extension exercise (assessed during screening)

You may not qualify if:

• Non-English speaking
• Regular use of prescription pain medications
• Current or history of chronic pain condition
• Currently taking blood-thinning medication
• Systemic medical condition known to affect sensation, such as uncontrolled diabetes or neurological conditions
• Any contraindication to the application of ice, such as: uncontrolled hypertension, cold urticaria, cryoglobulinemia, paroxysmal cold hemoglobinuria, circulatory compromise
• Known presence of cardiovascular, pulmonary, or metabolic disease
• Current use of tobacco products
• Not physically ready to exercise without a medical exam as indicated by the Physical Activity Readiness Questionnaire Plus (PAR-Q+)
• Surgery, injury, or fracture to the lower back or lower extremity within the past 6 months

Sponsors & Collaborators

• University of Central Florida: lead

Study Sites (1)

University of Central Florida

Orlando, Florida, 32765, United States

Location

Results Point of Contact

• Title: Abigail Wilson
• Organization: University of Central Florida

Abigail.Wilson@ucf.edu

407-823-1026

Study Officials

• Abigail Wilson

  University of Central Florida

  PRINCIPAL INVESTIGATOR

Publication Agreements

• PI is Sponsor Employee: No
• Restrictive Agreement: No

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assistant Professor

Study Record Dates

• First Submitted: September 27, 2022
• First Posted: September 30, 2022
• Study Start: October 31, 2022
• Primary Completion: March 27, 2023
• Study Completion: March 27, 2023
• Last Updated: December 9, 2024
• Results First Posted: December 9, 2024

Record last verified: 2024-10

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)