Knee Replacement and Sarcopenia

NCT06635356 | Completed

• 1 other identifier: IstanbulPMRTRH-kneerepsarc
• Study Type: observational
• Target: 37
• Locations: 1 country
• Sites: 1

Brief Summary

The presence of sarcopenia in patients planned to undergo knee prosthesis and the effect of knee prosthesis on sarcopenia will be investigated

Conditions

Knee Prosthesis; Knee Arthroplasty, Total; Sarcopenia

Outcome Measures

Primary Outcomes (4)

• Calf circumference measurement

  Calf circumference is an anthropometric measurement that indicates fatfree muscle mass and has been considered by the World Health Organization (WHO) the most sensitive index for evaluating the decrease in muscle mass. While the patient is standing, the measurement will be taken with a tape measure from the thickest point of the right and left calves without squeezing the skin.

  before surgery, 1st month after surgery, 3rd month after surgery

• Handgrip strength

  Handgrip strength will be measured using a Jamar hand grip dynamometer (Model 5030J1, Sammons Preston Rolyan, Bolingbrook, Illinois, USA). Measurements will be taken 3 times in a sitting position with the elbow flexed to 90° and the wrist in neutral position. The measured maximal grip strength will be recorded as hand grip strength.

  before surgery, 1st month after surgery, 3rd month after surgery

• Skeletal muscle mass

  Skeletal muscle mass will be evaluated using a Tanita DC-360 multi-frequency body composition analysis device.

  before surgery, 1st month after surgery, 3rd month after surgery

• Body Mass Index (BMI)

  BMI will be calculated as weight (kg) divided by height2 (m2)

  before surgery, 1st month after surgery, 3rd month after surgery

Study Arms (1)

The frequency and change of sarcopenia in patients undergoing knee arthroplasty

Sarcopenia frequency and changes will be investigated in women and men between the ages of 50 and 75 who will undergo knee prosthesis surgery, with follow-ups to be performed before the operation, in the first month and in the third month after the operation.

Eligibility Criteria

• Age: 50 Years - 75 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Female or male patients between the ages of 50-75 who underwent knee arthroplasty surgery in orthopedic clinics in Istanbul

You may qualify if:

• Being between 50-75 years old
• Undergoing knee arthroplasty surgery
• Patients who agreed to participate in the study and gave written consent

You may not qualify if:

• Having a history of malignancy
• Being under 50 and over 75 years old
• Having one of the muscle/nerve diseases

Sponsors & Collaborators

• Istanbul Physical Medicine Rehabilitation Training and Research Hospital: lead

Study Sites (1)

Istanbul Physical Medicine Rehabilitation Training and Research Hospital

Istanbul, 34192, Turkey (Türkiye)

Location

Related Publications (3)

• Tanaka S, Kayamoto A, Terai C, Nojiri S, Fugane Y, Mori T, Nagaya M, Kako M, Iida H, Osawa Y, Takegami Y, Nishida Y. Preoperative Sarcopenia Severity and Clinical Outcomes after Total Hip Arthroplasty. Nutrients. 2024 Jun 29;16(13):2085. doi: 10.3390/nu16132085.

  PMID: 38999833 BACKGROUND

• Tzartza CL, Karapalis N, Voulgaridou G, Zidrou C, Beletsiotis A, Chatziprodromidou IP, Giaginis C, Papadopoulou SK. Comparative Analysis on the Effect of Sarcopenia in Patients with Knee Osteoarthritis before and after Total Knee Arthroplasty. Diseases. 2023 Feb 22;11(1):36. doi: 10.3390/diseases11010036.

  PMID: 36975585 BACKGROUND

• Cruz-Jentoft AJ, Bahat G, Bauer J, Boirie Y, Bruyere O, Cederholm T, Cooper C, Landi F, Rolland Y, Sayer AA, Schneider SM, Sieber CC, Topinkova E, Vandewoude M, Visser M, Zamboni M; Writing Group for the European Working Group on Sarcopenia in Older People 2 (EWGSOP2), and the Extended Group for EWGSOP2. Sarcopenia: revised European consensus on definition and diagnosis. Age Ageing. 2019 Jan 1;48(1):16-31. doi: 10.1093/ageing/afy169.

  PMID: 30312372 BACKGROUND

MeSH Terms

Conditions

Sarcopenia

Condition Hierarchy (Ancestors)

Muscular Atrophy; Neuromuscular Manifestations; Neurologic Manifestations; Nervous System Diseases; Atrophy; Pathological Conditions, Anatomical; Pathological Conditions, Signs and Symptoms; Signs and Symptoms

Study Design

• Study Type: observational
• Observational Model: OTHER
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER GOV
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assistant Doctor

Study Record Dates

• First Submitted: October 8, 2024
• First Posted: October 10, 2024
• Study Start: October 1, 2024
• Primary Completion: April 29, 2025
• Study Completion: April 29, 2025
• Last Updated: March 27, 2026

Record last verified: 2024-10

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)