NCT07359508

Brief Summary

effect of propofol vs desflurane on ONSD

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
146

participants targeted

Target at P50-P75 for phase_4

Timeline
Completed

Started Jan 2024

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

January 10, 2024

Completed
1.4 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

June 15, 2025

Completed
1 month until next milestone

Study Completion

Last participant's last visit for all outcomes

July 15, 2025

Completed
6 months until next milestone

First Submitted

Initial submission to the registry

January 14, 2026

Completed
8 days until next milestone

First Posted

Study publicly available on registry

January 22, 2026

Completed
Last Updated

January 22, 2026

Status Verified

January 1, 2026

Enrollment Period

1.4 years

First QC Date

January 14, 2026

Last Update Submit

January 14, 2026

Conditions

Propofol Target-controlled InfusionDesfluraneOptic Nerve Sheath Diameter

Keywords

propofolONSD

Outcome Measures

Primary Outcomes (1)

  • Optic nerve sheath diameter(ONSD)

    ONSD will be measured in the operation thetaer

    before induction, introperative period for every 10 minutes

Study Arms (2)

Propofol group

EXPERIMENTAL

propofol infusion will be given in this group after induction of the patient

Drug: Propofol (Group P)

Desflurane

EXPERIMENTAL

desflurane inhalation will be given in this group, after induction

Drug: Desflurane

Interventions

DesfluraneDRUG

In the D group, anesthesia was maintained with oxygen/air (40:60), desflurane, fentanyl and vecuronium

Desflurane
Propofol (Group P)DRUG

In the P group, anesthesia was maintained with oxygen/air (40:60), propofol infusion @50 to 100mcg/kg/min, fentanyl and Vecuronium

Propofol group

Eligibility Criteria

Age18 Years - 60 Years
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64)

You may qualify if:

  • Patient aged 18-60 years ASA grade I or II scheduled for elective laparoscopic cholecystectomy

You may not qualify if:

  • patients with ophthalmological and cerebrovascular diseases, systemic infections, psychiatric disorders, pregnancy, Intracranial space occupying lesion, abnormal liver/kidney functions prior myocardial infarction.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

AIIMS

Raebareli, Uttar Pradesh, 229405, India

Location

MeSH Terms

Interventions

DesfluranePropofol

Intervention Hierarchy (Ancestors)

Ethyl EthersEthersOrganic ChemicalsMethyl EthersHydrocarbons, FluorinatedHydrocarbons, HalogenatedHydrocarbonsPhenolsBenzene DerivativesHydrocarbons, AromaticHydrocarbons, Cyclic

Study Design

Study Type
interventional
Phase
phase 4
Allocation
RANDOMIZED
Masking
DOUBLE
Who Masked
PARTICIPANT, CARE PROVIDER
Purpose
TREATMENT
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Vijay

Study Record Dates

First Submitted

January 14, 2026

First Posted

January 22, 2026

Study Start

January 10, 2024

Primary Completion

June 15, 2025

Study Completion

July 15, 2025

Last Updated

January 22, 2026

Record last verified: 2026-01

Data Sharing

IPD Sharing
Will share
Shared Documents
STUDY PROTOCOL

Locations

IN(1)