NCT06597071|Unknown
Parkinson Atypical Rating of Oculometric Patterns Evaluated Routinely
PARATROOPER
Use of Oculometric Measures in the Differential Diagnosis of Typical and Atypical Parkinsonian Conditions: a Pilot Study
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PARATROOPER
Use of Oculometric Measures in the Differential Diagnosis of Typical and Atypical Parkinsonian Conditions: a Pilot Study
Sponsor study identifier
interventional
40
1 country
1
Study Start
September 10, 2024
Actual (reported)Primary Completion
October 1, 2025
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
Study Completion
December 1, 2025
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
This is an observational longitudinal study in 4 cohorts of patients with Parkinsonian syndromes, who are visiting the Movement Disorders outpatient clinics. The aim of the study is to assess the difference of oculometric measures in different neurodegenerative brain conditions and their accuracy over time, and as compared to clinical diagnosis, in order to find a change over time, difference between subgroups and correlations with accepted clinical endpoints in subjects who meet the inclusion criteria and who provide a signed Informed Consent.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
December 1, 2025
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
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Some registry-reported names shown below are not yet linked in this graph.
Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
September 10, 2024
Actual (reported)September 11, 2024
Actual (reported)September 19, 2024
Actual (reported)October 1, 2025
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
December 1, 2025
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
Change of saccadic latency between subgroups
A difference between saccadic latency among the cohorts, enabling a categorization of different patients in study cohorts (p\<0.05)
12 months
Change of antisaccadic error rate between subgroups
A difference between antisaccadic error rate (%) among the cohorts, enabling a categorization of different patients in study cohorts (p\<0.05)
12 months
Change of saccadic latency over time as evaluated during visits
Difference between saccadic latency (ms) as quantified during each visit by the NeuraLight test measured using a statistical comparison of values (e.g. t-test, ANOVA), p\>0.05) over time during study period
12 months
Change of antisaccadic error rate over time as evaluated during visits
Difference between antisaccadic error rate (%) as quantified during each visit by the NeuraLight test measured using a statistical comparison of values (e.g. t-test, ANOVA), p\>0.05) over time during study period
12 months
Correlation between MDS-UPDRS score and its parts with saccadic latency
Correlation between MoCA score and its parts with anti-saccadic error rates
12 months
Correlation between MoCA score and its parts with smooth pursuit
12 months
Patients diagnosed with Parkinson's disease, ages 50-80, Hoehn \& Yahr scale 1-3
Patients diagnosed with PSP, according to actual diagnostic criteria from Höglinger GU et al, 2017.
Patients diagnosed with MSA, according to actual diagnostic criteria from Wenning et al, 2022.
NeuraLight software-based platform for PD patients
NeuraLight software-based platform for PSP patients
Instituto de Biomedicina de Sevilla (IBiS)
Seville, Spain
Habibi M, Oertel WH, White BJ, Brien DC, Coe BC, Riek HC, Perkins J, Yep R, Itti L, Timmermann L, Best C, Sittig E, Janzen A, Munoz DP. Eye tracking identifies biomarkers in alpha-synucleinopathies versus progressive supranuclear palsy. J Neurol. 2022 Sep;269(9):4920-4938. doi: 10.1007/s00415-022-11136-5. Epub 2022 Apr 30.
Pablo Mir, MD
IBIS (Instituto de Biomedicina de Sevilla), Calle Antonio Maura Montaner, Seville, Spain
First Submitted
September 11, 2024
First Posted
September 19, 2024
Study Start
September 10, 2024
Actual (reported)Primary Completion
October 1, 2025
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
The correlation between the Movement Disorder Society-Sponsored Revision of the Unified Parkinson's Disease Rating Scale (MDS-UPDRS, scored 0-to a maximum total of 199, indicating the worst possible disability from PD) and its parts with saccadic latency (ms) measured using R-Square (high correlation\>0.5, moderate correlation 0.2-0.5, low correlation\<0.2), p\<0.05)
12 months
Correlation between UMSARS score and its parts with saccadic latency
The correlation between the Unified Multiple System Atrophy Rating Scale (UMSARS) scored 0-to a maximum total of 48, indicating the worst possible disability from MSA) and its parts with saccadic latency (ms) measured using R-Square (high correlation\>0.5, moderate correlation 0.2-0.5, low correlation\<0.2), p\<0.05)
12 months
Correlation between PSP-CDS and its parts with saccadic latency
The correlation between the Progressive Supranuclear Palsy Clinical Deficits Scale (PSP-CDS) scored 0-to a maximum total of 100, indicating the worst possible disability from MSA) and its parts with saccadic latency (ms) measured using R-Square (high correlation\>0.5, moderate correlation 0.2-0.5, low correlation\<0.2), p\<0.05)
12 months
Healthy subjects with no neurological diseases or cognition deficits
NeuraLight software-based platform for MSA patients
NeuraLight software-based platform
Registry-reported names are shown in full. Names without a link have not yet been matched to a Syfrah profile.
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Study Completion
December 1, 2025
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
Last Updated
March 11, 2025
Record last verified: 2024-09
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