Management of Tick-borne Encephalitis

NCT06593249 | Completed

• 1 other identifier: TBE in ID or Neurology
• Study Type: observational
• Target: 318
• Locations: 1 country
• Sites: 1

Brief Summary

In this retrospective cohort study of patients with tick-borne encephalitis (TBE), potential differences in the clinical presentation at admission and diagnostic and therapeutic management of patients with TBE initially referred to infectious diseases or neurology departments were assessed. Associations between severity of acute illness and clinical outcome were also explored.

Conditions

Infectious Encephalitis

Keywords

tick-borne encephalitis; outcome; neuroimaging; lumbar puncture; clinical management

Outcome Measures

Primary Outcomes (1)

• head imaging

  Number (%) of patients with head imaging performed before proceeding to lumbar puncture.

  at admission

Study Arms (2)

TBE in Infectious Diseases Department

patients with TBE referred to ID

Other: No Intervention: Observational Cohort

TBE in Neurology Department

Patients with TBE in Neurology Department

Other: No Intervention: Observational Cohort

Interventions

No Intervention: Observational Cohort OTHER

no intervention, observational study

TBE in Infectious Diseases Department; TBE in Neurology Department

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients with tick-borne encepalitis referred to Infectious diseases or Neurology departments of the University Medical Centre Ljubljana, Slovenia during the COVID-19 pandemic (from March 2020 to September 2022).

You may qualify if:

• microbiologically confirmed tick-borne meningoencephalitis

You may not qualify if:

• Exchanged between ID and neurology within the first 48 hours due to organizational constraints
• Transferred from another hospital
• Lumbar puncture not performed
• Not fulfilling study criteria

Sponsors & Collaborators

• University Medical Centre Ljubljana: lead

Study Sites (1)

University Medical Centre Ljubljana, Ljublajana, Slovenia

Ljubljana, Slovenia

Location

MeSH Terms

Conditions

Infectious Encephalitis; Encephalitis, Tick-Borne

Condition Hierarchy (Ancestors)

Central Nervous System Infections; Infections; Encephalitis; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Neuroinflammatory Diseases; Encephalitis, Arbovirus; Encephalitis, Viral; Central Nervous System Viral Diseases; Arbovirus Infections; Vector Borne Diseases; Tick-Borne Diseases; Virus Diseases; RNA Virus Infections; Flavivirus Infections; Flaviviridae Infections

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: September 9, 2024
• First Posted: September 19, 2024
• Study Start: September 30, 2022
• Primary Completion: September 30, 2023
• Study Completion: June 30, 2024
• Last Updated: December 13, 2024

Record last verified: 2020-03

Locations

SL (1)