Smart Discharges for Older Children
2 other identifiers
observational
4,000
5 countries
7
Brief Summary
This study is an observational multi-country cohort study that aims to build algorithms that can identify children between 5 and 16 years of age admitted for proven or suspected sepsis who are at risk of mortality after they are discharged in East Africa. In low- and middle-income countries, about 5% of children discharged after hospitalization for sepsis will die in the weeks after returning home. Doctors and parents are often unaware of this period of vulnerability and are poorly equipped to identify or handle this critical situation. This project builds on past work that developed and evaluated models and the Smart Discharges program to predict, during hospitalization, an individual child's risk of recurrent illness and mortality, as well as to provide additional post-discharge support to at-risk children. Participants will be enrolled from facilities once they are admitted, collecting clinical and social variables. They will then be followed until 6 months post-discharge to understand what happens to them after they return home. This data will be evaluated to identify which variables collected at facilities can be predictive of mortality and recurrent illness after discharge.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for all trials
Started Jan 2024
Typical duration for all trials
7 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
Study Start
First participant enrolled
January 2, 2024
CompletedFirst Submitted
Initial submission to the registry
June 1, 2026
CompletedFirst Posted
Study publicly available on registry
June 5, 2026
CompletedPrimary Completion
Last participant's last visit for primary outcome
April 1, 2027
ExpectedStudy Completion
Last participant's last visit for all outcomes
April 1, 2027
June 5, 2026
June 1, 2026
3.2 years
June 1, 2026
June 1, 2026
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Post-discharge mortality
Discharge until 6 months post-discharge
Secondary Outcomes (1)
Post-discharge readmission
Discharge until 6 months post-discharge
Study Arms (1)
Pediatric patients 5-16 years of age
Pediatric patients admitted to a study site with suspected or proven infection
Interventions
This is a non-interventional study
Eligibility Criteria
The study population is children admitted to hospital facilities with suspected or proven sepsis between 5-16 years of age in the catchment area of the 8 study sites: Mbarara Regional Referral Hospital (Uganda), Jinja Regional Referral Hospital (Uganda), Uganda Martyrs Ibanda Hospital (Uganda), Holy Innocents Children's Hospital (Uganda), Sekou-Toure Regional Referral Hospital (Tanzania), Bugando Medical Centre (Tanzania), Masaka Hospital (Rwanda), University Teaching Hospital of Kigali (Rwanda), Ruhengeri Referral Hospital (Rwanda).
You may qualify if:
- Age between 0 and 16 years admitted to pediatric ward of hospital for proven or suspected infection
- Provide informed consent
- Ability to provide contact information (phone number or address) for phone or in-person follow-up
You may not qualify if:
- Child lives outside of the catchment area of a study site
- Admitted for elective procedures, trauma, or short-term observation
- Language barriers
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (7)
University of California, San Francisco
San Francisco, California, 94117, United States
Weill Cornell Medicine
Ithaca, New York, 14850, United States
University of Washington
Seattle, Washington, 98195, United States
BC Children's Hospital Research Institute
Vancouver, British Columbia, V5Z 2X8, Canada
The Rwanda Paediatric Association
Kigali, Rwanda
Catholic University Of Health And Allied Sciences
Mwanza, Tanzania
WALIMU
Mbarara, Uganda
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Central Study Contacts
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Assistant Professor
Study Record Dates
First Submitted
June 1, 2026
First Posted
June 5, 2026
Study Start
January 2, 2024
Primary Completion (Estimated)
April 1, 2027
Study Completion (Estimated)
April 1, 2027
Last Updated
June 5, 2026
Record last verified: 2026-06
Data Sharing
- IPD Sharing
- Will share
- Shared Documents
- STUDY PROTOCOL, SAP
- Time Frame
- Data will be deposited to an open access repository with moderated access within 2 years of study completion
- Access Criteria
- Moderated access on a case-by-case basis.
After the study period, a de-identified copy of the data will be prepared for deposition in a repository with open access with proper governance mechanisms. We will make every effort to prevent re-identification of subjects by coding data that has the potential of being identifiable. For example, we will convert all dates into meaningful decimal numbers (date of birth into days since birth and date of recruitment will be reduced to month of recruitment) and all locations will be coded into data that is useful but not specific (such as address converted to distance and direction from facility). We will ensure that data elements with small numbers of subjects (less than 10) will be coded or lumped to avoid identification. The de-identified study data will be made available using a data hosting service (e.g., Dataverse, Vivli, etc.)