CRP,CRP/Alb Ratio, N/L Ratio in Predictors of Both Systemic Infection and Survival in Patient with Sepsis in Assiut University Hospitals

NCT06586372 | Not Yet Recruiting

• 1 other identifier: predictors /Survival /sepsis
• Study Type: observational
• Target: 100
• Locations: 0 countries
• Sites: N/A

Brief Summary

the goal of this study is to asses the value of biomarker (CRP, CRP/Alb ratio, N/L ratio) in predictor of the outcome in normotensive patients with sepsis. The main question it aims to answer is: Does biomarker (CRP, CRP/Alb ratio, N/L ratio) can predict the outcome in patients with sepsis ?

Conditions

Sepsis; Systemic Infection

Outcome Measures

Primary Outcomes (2)

• CRP level in patients with sepsis

  baseline

• CRP/Alb ratio level in patients with sepsis

  baseline

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

the patients will be diagnosed according to international criteria and sepsis-3 definitions

You may qualify if:

• Patients with sepsis with normal blood pressure

You may not qualify if:

• \) Patients with history of corticosteroid therapy or antibiotic use before admission.
• \) Patients with hematologic disorders, malignant diseases, chemotherapy or radiotherapy within the previous month .
• )Patients with shock

Sponsors & Collaborators

• Assiut University: lead

Related Publications (11)

• Kinoshita A, Onoda H, Imai N, Iwaku A, Oishi M, Tanaka K, Fushiya N, Koike K, Nishino H, Matsushima M. The C-reactive protein/albumin ratio, a novel inflammation-based prognostic score, predicts outcomes in patients with hepatocellular carcinoma. Ann Surg Oncol. 2015 Mar;22(3):803-10. doi: 10.1245/s10434-014-4048-0. Epub 2014 Sep 5.

  PMID: 25190127 BACKGROUND

• Saito H, Kono Y, Murakami Y, Shishido Y, Kuroda H, Matsunaga T, Fukumoto Y, Osaki T, Ashida K, Fujiwara Y. Prognostic Significance of the Preoperative Ratio of C-Reactive Protein to Albumin and Neutrophil-Lymphocyte Ratio in Gastric Cancer Patients. World J Surg. 2018 Jun;42(6):1819-1825. doi: 10.1007/s00268-017-4400-1.

  PMID: 29270656 BACKGROUND

• Ranzani OT, Zampieri FG, Forte DN, Azevedo LC, Park M. C-reactive protein/albumin ratio predicts 90-day mortality of septic patients. PLoS One. 2013;8(3):e59321. doi: 10.1371/journal.pone.0059321. Epub 2013 Mar 12.

  PMID: 23555017 BACKGROUND

• Artero A, Zaragoza R, Camarena JJ, Sancho S, Gonzalez R, Nogueira JM. Prognostic factors of mortality in patients with community-acquired bloodstream infection with severe sepsis and septic shock. J Crit Care. 2010 Jun;25(2):276-81. doi: 10.1016/j.jcrc.2009.12.004. Epub 2010 Feb 10.

  PMID: 20149587 BACKGROUND

• Lobo SM, Lobo FR, Bota DP, Lopes-Ferreira F, Soliman HM, Melot C, Vincent JL. C-reactive protein levels correlate with mortality and organ failure in critically ill patients. Chest. 2003 Jun;123(6):2043-9. doi: 10.1378/chest.123.6.2043.

  PMID: 12796187 BACKGROUND

• Villacorta H, Masetto AC, Mesquita ET. C-reactive protein: an inflammatory marker with prognostic value in patients with decompensated heart failure. Arq Bras Cardiol. 2007 May;88(5):585-9. doi: 10.1590/s0066-782x2007000500014. English, Portuguese.

  PMID: 17589635 BACKGROUND

• Ho KM, Dobb GJ, Lee KY, Towler SC, Webb SA. C-reactive protein concentration as a predictor of intensive care unit readmission: a nested case-control study. J Crit Care. 2006 Sep;21(3):259-65. doi: 10.1016/j.jcrc.2006.01.005.

  PMID: 16990094 BACKGROUND

• Thijs LG, Hack CE. Time course of cytokine levels in sepsis. Intensive Care Med. 1995 Nov;21 Suppl 2:S258-63. doi: 10.1007/BF01740764.

  PMID: 8636533 BACKGROUND

• Barichello T, Generoso JS, Singer M, Dal-Pizzol F. Biomarkers for sepsis: more than just fever and leukocytosis-a narrative review. Crit Care. 2022 Jan 6;26(1):14. doi: 10.1186/s13054-021-03862-5.

  PMID: 34991675 BACKGROUND

• Faix JD. Biomarkers of sepsis. Crit Rev Clin Lab Sci. 2013 Jan-Feb;50(1):23-36. doi: 10.3109/10408363.2013.764490.

  PMID: 23480440 BACKGROUND

• Rello J, Valenzuela-Sanchez F, Ruiz-Rodriguez M, Moyano S. Sepsis: A Review of Advances in Management. Adv Ther. 2017 Nov;34(11):2393-2411. doi: 10.1007/s12325-017-0622-8. Epub 2017 Oct 11.

  PMID: 29022217 BACKGROUND

MeSH Terms

Conditions

Sepsis; Toxemia

Condition Hierarchy (Ancestors)

Infections; Systemic Inflammatory Response Syndrome; Inflammation; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Central Study Contacts

Esraa Ahmed Mohamed Gomaa, resident doctors

CONTACT

+201155339230; esr43872@gmail.com

Nour Eldine Abd-Elaseame, professor

CONTACT

+201005035180; noorelhefny@gmail.com

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: doctor

Study Record Dates

• First Submitted: September 4, 2024
• First Posted: September 19, 2024
• Study Start: October 1, 2024
• Primary Completion: October 30, 2025
• Study Completion: November 30, 2025
• Last Updated: September 19, 2024

Record last verified: 2024-09

Data Sharing

• IPD Sharing: Will not share