NCT06545370

Brief Summary

The current study intends to examine the influence of nurse-led education on patients with chronic heart failure and their caregivers, with the goal of optimizing care for both and improving patients\' clinical outcomes.

Trial Health

77
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
280

participants targeted

Target at P75+ for not_applicable heart-failure

Timeline
17mo left

Started Sep 2024

Typical duration for not_applicable heart-failure

Geographic Reach
1 country

2 active sites

Status
recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

Study Progress56%
Sep 2024Sep 2027

First Submitted

Initial submission to the registry

July 25, 2024

Completed
15 days until next milestone

First Posted

Study publicly available on registry

August 9, 2024

Completed
23 days until next milestone

Study Start

First participant enrolled

September 1, 2024

Completed
2 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

September 1, 2026

Expected
1 year until next milestone

Study Completion

Last participant's last visit for all outcomes

September 1, 2027

Last Updated

September 24, 2025

Status Verified

September 1, 2025

Enrollment Period

2 years

First QC Date

July 25, 2024

Last Update Submit

September 19, 2025

Conditions

Keywords

Heart failureinformal caregiverspatient outcomesnurse-led education

Outcome Measures

Primary Outcomes (3)

  • Heart Failure Patients' Quality of Life

    The heart failure patient's quality of life: To assess the quality of life of patients with heart failure, the Greek version of the Minnesota Living with Heart Failure Questionnaire (MLwHFQ) was used.

    from date of first communication with patient until the date of documented progression, assessed up estimate to 24 months.

  • Heart failure patients' self-care

    The self-care behavior of heart failure patients: The Hippocratic Heart Failure Self-Care Scale is an 18-item scale created by Greek researchers (Brokalaki et al., 2024).

    from date of first communication with patient until the date of documented progression, assessed up estimate to 24 months.

  • Medication adherence

    The adherence of pharmacological treatment to heart failure patients: To assess adherence to medication in patients with cardiac deficiency, the Greek version of SEAMS will be used (Theofilou, 2023). SEAMS is a 13-item self-report medication adherence scale.

    from date of first communication with patient until the date of documented progression, assessed up estimate to 24 months.

Secondary Outcomes (3)

  • Caregivers' quality of life

    From date of first communication with patient until the date of documented progression, assessed up estimate to 24 months.

  • Caregiving burden

    From date of first communication with patient until the date of documented progression, assessed up estimate to 24 months.

  • Sense of guilt

    From date of first communication with patient until the date of documented progression, assessed up estimate to 24 months.

Study Arms (3)

Control Group - No Intervention Group

NO INTERVENTION

the control group (Group A) will receive standard care based on the policies and protocols of primary health care

Intervention 1 group - Patients' education

EXPERIMENTAL

the first intervention group (Group B) will receive nurse-led education through oral sessions, educational materials, and regular phone calls

Other: Intervention 1 / Nurse-led patients' education

Intervention 2 - Patients' and caregivers' education

EXPERIMENTAL

the second intervention group (Group C) will receive the described nurse-led education while caregivers also undergo training through oral sessions, phone calls, and appropriately designed educational materials

Other: Intervention 1 / Nurse-led patients' educationOther: Intervention 2 / Nurse-led patients' & caregivers' education

Interventions

nurse-led education through oral sessions, educational materials, and regular phone calls

Intervention 1 group - Patients' educationIntervention 2 - Patients' and caregivers' education

nurse-led education while caregivers also undergo training through oral sessions, phone calls, and appropriately designed educational materials

Intervention 2 - Patients' and caregivers' education

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Age ≥ 18 years
  • Patients recently hospitalized due to the disease
  • Patients and caregivers who are literate in Greek
  • Patients and caregivers who provide written informed consent for their participation in the study
  • Patients diagnosed with heart failure for at least 6 months
  • Caregivers who have been involved in the care of the patients for at least 6 months
  • Patients taking medication according to the guidelines of the European Society of Cardiology

You may not qualify if:

  • History of psychiatric disease, recent history of alcohol or/and drug abuse, dementia, and Alzheimer\'s disease (for patients and caregivers)
  • Absence of an informal caregiver according to their statement

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (2)

Hellenic Mediterranean University

Heraklion, Crete, 71410, Greece

COMPLETED

Hellenic Mediterranean University

Heraklion, Greece

RECRUITING

MeSH Terms

Conditions

Heart Failure

Condition Hierarchy (Ancestors)

Heart DiseasesCardiovascular Diseases

Central Study Contacts

Konstantinos Giakoumidakis, Associate Professor

CONTACT

Elefteria Markaki, PhD candidate

CONTACT

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
NONE
Purpose
SUPPORTIVE CARE
Intervention Model
SEQUENTIAL
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Associate Professor in Clinical Nursing - Chronic Diseases Management

Study Record Dates

First Submitted

July 25, 2024

First Posted

August 9, 2024

Study Start

September 1, 2024

Primary Completion (Estimated)

September 1, 2026

Study Completion (Estimated)

September 1, 2027

Last Updated

September 24, 2025

Record last verified: 2025-09

Data Sharing

IPD Sharing
Will not share

The investigators do not plan to share individual participant data (IPD) collected in this study due to concerns about patient privacy, and lack of infrastructure for data sharing

Locations