The Effect of Injectable PRF Vs LLL on Orthodontic Tooth Movement

NCT06520761 | Unknown

• 1 other identifier: ORTHO-108-5-b
• Study Type: interventional
• Target: 20
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of the present study is to compare the effect of injectable platelet fibrin and Low Level LASER therapy on the rate of upper canine retraction, and on root resorption of the canine

Conditions

Rate of Canine Retraction; Root Resorption

Outcome Measures

Primary Outcomes (1)

• Rate of canine retraction

  measure the rate of distal movement of the upper canine

  4 month

Secondary Outcomes (1)

• Root resorption of upper canine

  4 month

Study Arms (2)

injectable platelet rich fibrin

EXPERIMENTAL

blood sample is collected from the patient, centrifuged at 700rpm for 3 minutes then the resulted injectable platelet rich fibrin is injected around the upper right canine while the upper left canine act as a control

Procedure: Injectable platelet rich fibrin

Low Level LASER

EXPERIMENTAL

low level laser from diode laser machine is applied around the upper right canine and the upper left canine acts as a control

Device: Low Level LASER

Interventions

Injectable platelet rich fibrin PROCEDURE

blood sample obtained from the participant, centrifuged at 700 rpm to produce injectable platelet rich fibrin, this will be injected around the upper canine

injectable platelet rich fibrin

Low Level LASER DEVICE

Diode LASER device is used to apply Low Level LASER around the upper canine

Low Level LASER

Eligibility Criteria

• Age: 18 Years - 25 Years
• Sex: female
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Patients with age 18 years or older.
• Presence of all permanent teeth except for the third molar.
• Presence of malocclusion requiring maxillary first premolar extraction such as (class II division 1 or bimaxillary dentoalveolar protrusion).

You may not qualify if:

• Patient with a history of previous orthodontic treatment.
• Medical problems may interfere with orthodontic treatment.
• Bad oral hygiene.

Sponsors & Collaborators

• Faculty of Dental Medicine for Girls: lead

Study Sites (1)

Faculty of Dental Medicine for Girls Al Azhar university

Cairo, Naser City, 02, Egypt

Location

Related Publications (1)

• Zeitounlouian TS, Zeno KG, Brad BA, Haddad RA. Effect of injectable platelet-rich fibrin (i-PRF) in accelerating orthodontic tooth movement : A randomized split-mouth-controlled trial. J Orofac Orthop. 2021 Jul;82(4):268-277. doi: 10.1007/s00056-020-00275-x. Epub 2021 Jan 22.

  PMID: 33481053 BACKGROUND

Related Links

• The role of platelet-rich fibrin (PRF) in accelerating orthodontic tooth movement has been controversially discussed in available clinical studies. Objective: To investigate the effectiveness of i-PRF in accelerating maxillary canine retraction.

MeSH Terms

Conditions

Root Resorption

Interventions

Low-Level Light Therapy

Condition Hierarchy (Ancestors)

Tooth Resorption; Tooth Diseases; Stomatognathic Diseases

Intervention Hierarchy (Ancestors)

Laser Therapy; Therapeutics; Phototherapy

Study Officials

• Samir A Ebrahim, Professor

  Head of orthodontic department at faculty of Dental Medicine for Girls Al-Azhar university

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: OUTCOMES ASSESSOR
• Purpose: OTHER
• Intervention Model: PARALLEL
• Sponsor Type: OTHER GOV
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: July 20, 2024
• First Posted: July 25, 2024
• Study Start: November 1, 2022
• Primary Completion: December 1, 2024
• Study Completion: December 1, 2024
• Last Updated: July 25, 2024

Record last verified: 2023-10

Data Sharing

• IPD Sharing: Will not share

Locations

EG (1)