NCT06498635

Brief Summary

This phase III trial compares durvalumab to the usual approach (patient observation) after surgery for the treatment of patients with early-stage non-small cell lung cancer. Immunotherapy with monoclonal antibodies, such as durvalumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. The usual approach for patients who are not in a study is to closely watch a patient's condition after surgery and to have regular visits with their doctor to watch for signs of the cancer coming back. Usually, patients do not receive further treatment unless the cancer returns. This study will help determine whether this different approach with durvalumab is better, the same, or worse than the usual approach of observation. Giving durvalumab may help patients live longer and prevent early-stage non-small cell lung cancer from coming back as compared to the usual approach.

Trial Health

77
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
306

participants targeted

Target at P50-P75 for phase_3

Timeline
161mo left

Started Apr 2025

Longer than P75 for phase_3

Geographic Reach
1 country

225 active sites

Status
recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Progress7%
Apr 2025Jul 2039

First Submitted

Initial submission to the registry

July 10, 2024

Completed
2 days until next milestone

First Posted

Study publicly available on registry

July 12, 2024

Completed
9 months until next milestone

Study Start

First participant enrolled

April 1, 2025

Completed
14.3 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

July 15, 2039

Expected
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

July 15, 2039

Last Updated

April 14, 2026

Status Verified

April 1, 2026

Enrollment Period

14.3 years

First QC Date

July 10, 2024

Last Update Submit

April 11, 2026

Conditions

Outcome Measures

Primary Outcomes (1)

  • Disease-free survival (DFS)

    Will be assessed using a 1-sided 5% level log-rank test accounting for interim testing, stratified on the randomization stratification factors.

    From date of randomization to the earliest event defined as date of first documentation of recurrence, any new lung cancer (even in the contralateral lung), or death due to any cause, assessed up to 10 years

Secondary Outcomes (3)

  • Event-free survival (EFS)

    From date of randomization to date of first occurrence of EFS event, assessed up to 10 years

  • Overall survival (OS)

    From date of randomization to date of death due to any cause, assessed up to 10 years

  • Incidence of adverse events

    Up to 10 years

Other Outcomes (2)

  • Patient reported outcomes

    Up to 10 years

  • Estimates of the primary outcome treatment effect

    Up to 10 years

Study Arms (2)

Arm I (durvalumab)

EXPERIMENTAL

Patients receive durvalumab IV over 60 minutes on day 1 of each cycle. Treatment repeats every 28 days for up to 12 cycles in the absence of disease progression or unacceptable toxicity. Patients undergo CT and blood sample collection throughout the trial.

Procedure: Biospecimen CollectionProcedure: Computed TomographyBiological: DurvalumabOther: Questionnaire Administration

Arm II (active surveillance)

ACTIVE COMPARATOR

Patients undergo active surveillance for 12 months on study. Patients undergo CT and blood sample collection throughout the trial.

Procedure: Biospecimen CollectionProcedure: Computed TomographyOther: Patient ObservationOther: Questionnaire Administration

Interventions

Undergo CT

Also known as: CAT, CAT Scan, Computed Axial Tomography, Computerized Axial Tomography, Computerized axial tomography (procedure), Computerized Tomography, Computerized Tomography (CT) scan, CT, CT Scan, Diagnostic CAT Scan, Diagnostic CAT Scan Service Type, tomography
Arm I (durvalumab)Arm II (active surveillance)
DurvalumabBIOLOGICAL

Given IV

Also known as: Imfinzi, Immunoglobulin G1, Anti-(Human Protein B7-H1) (Human Monoclonal MEDI4736 Heavy Chain), Disulfide with Human Monoclonal MEDI4736 Kappa-chain, Dimer, MEDI 4736, MEDI-4736, MEDI4736
Arm I (durvalumab)

Undergo active surveillance

Also known as: Active Surveillance, deferred therapy, expectant management, Observation, Watchful Waiting
Arm II (active surveillance)

Undergo blood sample collection

Also known as: Biological Sample Collection, Biospecimen Collected, Specimen Collection
Arm I (durvalumab)Arm II (active surveillance)

Ancillary studies

Arm I (durvalumab)Arm II (active surveillance)

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Participants must have histologically or cytological confirmed diagnosis of clinical stage II-IIIB (excluding clinical N3 disease) non-small cell lung cancer (NSCLC)
  • Participants must have had a complete (R0) resection of NSCLC (with appropriate lymph node sampling as defined by the National Comprehensive Cancer Network \[NCCN\] guidelines) within 84 days (12 weeks) prior to randomization. Acceptable types of surgical resection are: lobectomy, sleeve resection, bi-lobectomy, or pneumonectomy. Wedge resection is not allowed.
  • Note the NCCN guidelines: N1 and N2 node resection and mapping is a routine component of lung cancer resections. It is recommended at a minimum one N1 and three N2 stations is sampled or complete lymph node dissection. Formal ipsilateral mediastinal lymph node dissection is indicated for participants undergoing resection for N2 disease
  • Participants must have a pathologic complete response (pCR) (no viable tumor in the resected specimen or lymph nodes), as determined by local pathology review
  • Participants must have a PD-L1 status result (e.g. \[\< 1% versus \>= 1% or unknown\])
  • Participants must not have known EGFR mutations, or ALK gene fusion
  • Participants must have received at least two cycles of neoadjuvant platinum-based chemotherapy and anti-PD-1 or anti-PD-L1 therapy. The neoadjuvant treatment must be Food and Drug Administration (FDA) approved and standard of care as listed in NCCN guidelines
  • Participants must not be planning to receive any concurrent non-protocol directed chemotherapy, immunotherapy, biologic or hormonal therapy for NSCLC treatment while receiving treatment on this study
  • Participants must not have received any prior systemic therapy (systemic chemotherapy, immunotherapy or investigational drug) within 28 days prior to randomization
  • Participants must not have medical contraindications or severe adverse events to receiving anti-PD-1 or anti-PD-L1 therapy
  • Participants must not have received post-operative radiation therapy (PORT) for NSCLC
  • Participants must not have any unresolved toxicity National Cancer Institute (NCI) CTCAE grade ≥ 2 from previous anticancer therapy with the exception of alopecia, and vitiligo. Note, participants with grade ≥2 neuropathy may be included at the discretion of the treating investigator. Note, participants with irreversible toxicity not reasonably expected to be exacerbated by treatment with durvalumab may be included at the discretion of the treating investigator
  • Participant must be ≥ 18 years old at time of study entry
  • Participants must have body weight \> 30 kg
  • Participant must have Zubrod performance status of 0-2
  • +21 more criteria

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (225)

NEA Baptist Memorial Hospital and Fowler Family Cancer Center - Jonesboro

Jonesboro, Arkansas, 72401, United States

RECRUITING

Tower Cancer Research Foundation

Beverly Hills, California, 90211, United States

RECRUITING

Veterans Affairs Loma Linda Healthcare System

Loma Linda, California, 92357, United States

RECRUITING

Cedars Sinai Medical Center

Los Angeles, California, 90048, United States

RECRUITING

University of California Davis Comprehensive Cancer Center

Sacramento, California, 95817, United States

RECRUITING

Torrance Memorial Physician Network - Cancer Care

Torrance, California, 90505, United States

RECRUITING

Saint Mary's Hospital and Regional Medical Center

Grand Junction, Colorado, 81501, United States

RECRUITING

Hartford HealthCare - Avon

Avon, Connecticut, 06001, United States

RECRUITING

Hartford Hospital

Hartford, Connecticut, 06102, United States

RECRUITING

Hartford HealthCare - Manchester

Manchester, Connecticut, 06042, United States

RECRUITING

Midstate Medical Center

Meriden, Connecticut, 06451, United States

RECRUITING

The Hospital of Central Connecticut

New Britain, Connecticut, 06050, United States

RECRUITING

Beebe South Coastal Health Campus

Millville, Delaware, 19967, United States

RECRUITING

Helen F Graham Cancer Center

Newark, Delaware, 19713, United States

RECRUITING

Medical Oncology Hematology Consultants PA

Newark, Delaware, 19713, United States

RECRUITING

Beebe Health Campus

Rehoboth Beach, Delaware, 19971, United States

RECRUITING

Moffitt Cancer Center-International Plaza

Tampa, Florida, 33607, United States

SUSPENDED

Moffitt Cancer Center - McKinley Campus

Tampa, Florida, 33612, United States

SUSPENDED

Moffitt Cancer Center

Tampa, Florida, 33612, United States

SUSPENDED

Emory University Hospital Midtown

Atlanta, Georgia, 30308, United States

RECRUITING

Emory University Hospital/Winship Cancer Institute

Atlanta, Georgia, 30322, United States

RECRUITING

Emory Saint Joseph's Hospital

Atlanta, Georgia, 30342, United States

RECRUITING

Emory Decatur Hospital

Decatur, Georgia, 30033, United States

RECRUITING

Emory Johns Creek Hospital

Johns Creek, Georgia, 30097, United States

RECRUITING

Hawaii Cancer Care Inc - Waterfront Plaza

Honolulu, Hawaii, 96813, United States

RECRUITING

Queen's Cancer Cenrer - POB I

Honolulu, Hawaii, 96813, United States

RECRUITING

Queen's Medical Center

Honolulu, Hawaii, 96813, United States

RECRUITING

Queen's Cancer Center - Kuakini

Honolulu, Hawaii, 96817, United States

RECRUITING

Hawaii Cancer Care - Westridge

‘Aiea, Hawaii, 96701, United States

RECRUITING

The Queen's Medical Center - West Oahu

‘Ewa Beach, Hawaii, 96706, United States

RECRUITING

Saint Luke's Cancer Institute - Boise

Boise, Idaho, 83712, United States

RECRUITING

Kootenai Health - Coeur d'Alene

Coeur d'Alene, Idaho, 83814, United States

RECRUITING

Saint Luke's Cancer Institute - Fruitland

Fruitland, Idaho, 83619, United States

RECRUITING

Saint Luke's Cancer Institute - Meridian

Meridian, Idaho, 83642, United States

RECRUITING

Saint Alphonsus Cancer Care Center-Nampa

Nampa, Idaho, 83687, United States

RECRUITING

Saint Luke's Cancer Institute - Nampa

Nampa, Idaho, 83687, United States

RECRUITING

Kootenai Clinic Cancer Services - Post Falls

Post Falls, Idaho, 83854, United States

RECRUITING

Kootenai Clinic Cancer Services - Sandpoint

Sandpoint, Idaho, 83864, United States

RECRUITING

Northwestern University

Chicago, Illinois, 60611, United States

RECRUITING

Northwestern Medicine Cancer Center Kishwaukee

DeKalb, Illinois, 60115, United States

RECRUITING

Northwestern Medicine Cancer Center Delnor

Geneva, Illinois, 60134, United States

RECRUITING

Northwestern Medicine Glenview Outpatient Center

Glenview, Illinois, 60026, United States

RECRUITING

Northwestern Medicine Grayslake Outpatient Center

Grayslake, Illinois, 60030, United States

RECRUITING

Northwestern Medicine Huntley Hospital

Huntley, Illinois, 60142, United States

RECRUITING

Northwestern Medicine Lake Forest Hospital

Lake Forest, Illinois, 60045, United States

RECRUITING

Loyola University Medical Center

Maywood, Illinois, 60153, United States

RECRUITING

Northwestern Medicine Oak Brook

Oak Brook, Illinois, 60523, United States

RECRUITING

Northwestern Medicine Orland Park

Orland Park, Illinois, 60462, United States

RECRUITING

Northwestern Medicine Cancer Center Warrenville

Warrenville, Illinois, 60555, United States

RECRUITING

IU Health West Hospital

Avon, Indiana, 46123, United States

RECRUITING

IU Health North Hospital

Carmel, Indiana, 46032, United States

RECRUITING

Indiana University/Melvin and Bren Simon Cancer Center

Indianapolis, Indiana, 46202, United States

RECRUITING

Mary Greeley Medical Center

Ames, Iowa, 50010, United States

RECRUITING

McFarland Clinic - Ames

Ames, Iowa, 50010, United States

RECRUITING

McFarland Clinic - Boone

Boone, Iowa, 50036, United States

SUSPENDED

McFarland Clinic - Trinity Cancer Center

Fort Dodge, Iowa, 50501, United States

RECRUITING

McFarland Clinic - Jefferson

Jefferson, Iowa, 50129, United States

SUSPENDED

McFarland Clinic - Marshalltown

Marshalltown, Iowa, 50158, United States

RECRUITING

HaysMed

Hays, Kansas, 67601, United States

RECRUITING

Lawrence Memorial Hospital

Lawrence, Kansas, 66044, United States

RECRUITING

The University of Kansas Cancer Center - Olathe

Olathe, Kansas, 66061, United States

RECRUITING

Salina Regional Health Center

Salina, Kansas, 67401, United States

RECRUITING

University of Kansas Health System Saint Francis Campus

Topeka, Kansas, 66606, United States

RECRUITING

University Medical Center New Orleans

New Orleans, Louisiana, 70112, United States

RECRUITING

Harold Alfond Center for Cancer Care

Augusta, Maine, 04330, United States

RECRUITING

MaineHealth Maine Medical Center- Scarborough

Scarborough, Maine, 04074, United States

RECRUITING

MaineHealth Cancer Care and IV Therapy - South Portland

South Portland, Maine, 04106, United States

RECRUITING

UPMC Western Maryland

Cumberland, Maryland, 21502, United States

RECRUITING

Beverly Hospital

Beverly, Massachusetts, 01915, United States

RECRUITING

Lahey Hospital and Medical Center

Burlington, Massachusetts, 01805, United States

RECRUITING

Addison Gilbert Hospital

Gloucester, Massachusetts, 01930, United States

RECRUITING

Lahey Medical Center-Peabody

Peabody, Massachusetts, 01960, United States

RECRUITING

Baystate Medical Center

Springfield, Massachusetts, 01199, United States

RECRUITING

University of Michigan Rogel Cancer Center

Ann Arbor, Michigan, 48109, United States

RECRUITING

Bronson Battle Creek

Battle Creek, Michigan, 49017, United States

RECRUITING

Trinity Health IHA Medical Group Hematology Oncology - Brighton

Brighton, Michigan, 48114, United States

RECRUITING

University of Michigan - Brighton Center for Specialty Care

Brighton, Michigan, 48116, United States

RECRUITING

Trinity Health IHA Medical Group Hematology Oncology - Canton

Canton, Michigan, 48188, United States

RECRUITING

Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital

Chelsea, Michigan, 48118, United States

RECRUITING

Henry Ford Health Saint John Hospital

Detroit, Michigan, 48236, United States

RECRUITING

Henry Ford River District Hospital

East China Township, Michigan, 48054, United States

RECRUITING

OSF Saint Francis Hospital and Medical Group

Escanaba, Michigan, 49829, United States

RECRUITING

Cancer Hematology Centers - Flint

Flint, Michigan, 48503, United States

RECRUITING

Genesee Hematology Oncology PC

Flint, Michigan, 48503, United States

SUSPENDED

Genesys Hurley Cancer Institute

Flint, Michigan, 48503, United States

RECRUITING

Corewell Health Grand Rapids Hospitals - Butterworth Hospital

Grand Rapids, Michigan, 49503, United States

RECRUITING

Trinity Health Grand Rapids Hospital

Grand Rapids, Michigan, 49503, United States

RECRUITING

Henry Ford Saint John Hospital - Academic

Grosse Pointe Woods, Michigan, 48236, United States

RECRUITING

Henry Ford Saint John Hospital - Breast

Grosse Pointe Woods, Michigan, 48236, United States

RECRUITING

Henry Ford Saint John Hospital - Van Elslander

Grosse Pointe Woods, Michigan, 48236, United States

RECRUITING

Bronson Methodist Hospital

Kalamazoo, Michigan, 49007, United States

RECRUITING

West Michigan Cancer Center

Kalamazoo, Michigan, 49007, United States

RECRUITING

University of Michigan Health - Sparrow Lansing

Lansing, Michigan, 48912, United States

RECRUITING

Trinity Health Saint Mary Mercy Livonia Hospital

Livonia, Michigan, 48154, United States

RECRUITING

Henry Ford Saint John Hospital - Macomb Medical

Macomb, Michigan, 48044, United States

RECRUITING

Henry Ford Warren Hospital - Breast Macomb

Macomb, Michigan, 48044, United States

RECRUITING

Trinity Health Muskegon Hospital

Muskegon, Michigan, 49444, United States

RECRUITING

Corewell Health Lakeland Hospitals - Niles Hospital

Niles, Michigan, 49120, United States

RECRUITING

Cancer and Hematology Centers of Western Michigan - Norton Shores

Norton Shores, Michigan, 49444, United States

RECRUITING

Trinity Health Saint Joseph Mercy Oakland Hospital

Pontiac, Michigan, 48341, United States

RECRUITING

Corewell Health Reed City Hospital

Reed City, Michigan, 49677, United States

RECRUITING

Corewell Health William Beaumont University Hospital

Royal Oak, Michigan, 48073, United States

RECRUITING

Corewell Health Lakeland Hospitals - Marie Yeager Cancer Center

Saint Joseph, Michigan, 49085, United States

RECRUITING

Corewell Health Lakeland Hospitals - Saint Joseph Hospital

Saint Joseph, Michigan, 49085, United States

RECRUITING

Munson Medical Center

Traverse City, Michigan, 49684, United States

RECRUITING

Henry Ford Health Warren Hospital

Warren, Michigan, 48093, United States

RECRUITING

Henry Ford Madison Heights Hospital - Breast

Warren, Michigan, 48093, United States

RECRUITING

Henry Ford Warren Hospital - GLCMS

Warren, Michigan, 48093, United States

RECRUITING

University of Michigan Health - West

Wyoming, Michigan, 49519, United States

RECRUITING

Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus

Ypsilanti, Michigan, 48197, United States

RECRUITING

Sanford Joe Lueken Cancer Center

Bemidji, Minnesota, 56601, United States

RECRUITING

Essentia Health Saint Joseph's Medical Center

Brainerd, Minnesota, 56401, United States

RECRUITING

Mercy Hospital

Coon Rapids, Minnesota, 55433, United States

RECRUITING

Essentia Health - Deer River Clinic

Deer River, Minnesota, 56636, United States

RECRUITING

Essentia Health Cancer Center

Duluth, Minnesota, 55805, United States

RECRUITING

Fairview Southdale Hospital

Edina, Minnesota, 55435, United States

RECRUITING

Essentia Health Hibbing Clinic

Hibbing, Minnesota, 55746, United States

RECRUITING

Abbott-Northwestern Hospital

Minneapolis, Minnesota, 55407, United States

RECRUITING

Minneapolis VA Medical Center

Minneapolis, Minnesota, 55417, United States

RECRUITING

Park Nicollet Clinic - Saint Louis Park

Saint Louis Park, Minnesota, 55416, United States

RECRUITING

Regions Hospital

Saint Paul, Minnesota, 55101, United States

RECRUITING

United Hospital

Saint Paul, Minnesota, 55102, United States

RECRUITING

Essentia Health Sandstone

Sandstone, Minnesota, 55072, United States

RECRUITING

Essentia Health Virginia Clinic

Virginia, Minnesota, 55792, United States

RECRUITING

Baptist Memorial Hospital and Cancer Center-Golden Triangle

Columbus, Mississippi, 39705, United States

RECRUITING

Baptist Cancer Center-Grenada

Grenada, Mississippi, 38901, United States

RECRUITING

Baptist Memorial Hospital and Cancer Center-Union County

New Albany, Mississippi, 38652, United States

RECRUITING

Baptist Memorial Hospital and Cancer Center-Oxford

Oxford, Mississippi, 38655, United States

RECRUITING

Baptist Memorial Hospital and Cancer Center-Desoto

Southhaven, Mississippi, 38671, United States

RECRUITING

Mercy Oncology and Hematology - Clayton-Clarkson

Ballwin, Missouri, 63011, United States

RECRUITING

University Health Truman Medical Center

Kansas City, Missouri, 64108, United States

RECRUITING

Mercy Hospital South

St Louis, Missouri, 63128, United States

RECRUITING

Mercy Hospital Saint Louis

St Louis, Missouri, 63141, United States

RECRUITING

Community Hospital of Anaconda

Anaconda, Montana, 59711, United States

RECRUITING

Billings Clinic Cancer Center

Billings, Montana, 59101, United States

RECRUITING

Saint Vincent Frontier Cancer Center

Billings, Montana, 59102, United States

RECRUITING

Bozeman Health Deaconess Hospital

Bozeman, Montana, 59715, United States

RECRUITING

Benefis Sletten Cancer Institute

Great Falls, Montana, 59405, United States

RECRUITING

Logan Health Medical Center

Kalispell, Montana, 59901, United States

RECRUITING

Community Medical Center

Missoula, Montana, 59804, United States

RECRUITING

University of New Mexico Cancer Center

Albuquerque, New Mexico, 87106, United States

RECRUITING

Roswell Park Cancer Institute

Buffalo, New York, 14263, United States

RECRUITING

Montefiore Medical Center-Einstein Campus

The Bronx, New York, 10461, United States

RECRUITING

Montefiore Medical Center - Moses Campus

The Bronx, New York, 10467, United States

RECRUITING

James J Peters VA Medical Center

The Bronx, New York, 10468, United States

RECRUITING

Duke Cancer Center Cary

Cary, North Carolina, 27518, United States

RECRUITING

Duke University Medical Center

Durham, North Carolina, 27710, United States

RECRUITING

FirstHealth of the Carolinas-Moore Regional Hospital

Pinehurst, North Carolina, 28374, United States

RECRUITING

Duke Cancer Center Raleigh

Raleigh, North Carolina, 27609, United States

RECRUITING

Sanford Bismarck Medical Center

Bismarck, North Dakota, 58501, United States

RECRUITING

Essentia Health Cancer Center-South University Clinic

Fargo, North Dakota, 58103, United States

RECRUITING

Sanford Broadway Medical Center

Fargo, North Dakota, 58122, United States

RECRUITING

Sanford Roger Maris Cancer Center

Fargo, North Dakota, 58122, United States

RECRUITING

Aultman Health Foundation

Canton, Ohio, 44710, United States

RECRUITING

Miami Valley Hospital South

Centerville, Ohio, 45459, United States

RECRUITING

Ohio State University Comprehensive Cancer Center

Columbus, Ohio, 43210, United States

RECRUITING

Miami Valley Hospital

Dayton, Ohio, 45409, United States

RECRUITING

Miami Valley Hospital North

Dayton, Ohio, 45415, United States

RECRUITING

Atrium Medical Center-Middletown Regional Hospital

Franklin, Ohio, 45005-1066, United States

RECRUITING

Miami Valley Cancer Care and Infusion

Greenville, Ohio, 45331, United States

RECRUITING

Upper Valley Medical Center

Troy, Ohio, 45373, United States

RECRUITING

University of Oklahoma Health Sciences Center

Oklahoma City, Oklahoma, 73104, United States

RECRUITING

Providence Hood River Memorial Hospital

Hood River, Oregon, 97031, United States

RECRUITING

Providence Newberg Medical Center

Newberg, Oregon, 97132, United States

RECRUITING

Providence Willamette Falls Medical Center

Oregon City, Oregon, 97045, United States

RECRUITING

Providence Portland Medical Center

Portland, Oregon, 97213, United States

RECRUITING

Providence Saint Vincent Medical Center

Portland, Oregon, 97225, United States

RECRUITING

Oregon Health and Science University

Portland, Oregon, 97239, United States

RECRUITING

Lehigh Valley Hospital-Cedar Crest

Allentown, Pennsylvania, 18103, United States

RECRUITING

Lehigh Valley Hospital - Muhlenberg

Bethlehem, Pennsylvania, 18017, United States

RECRUITING

Bryn Mawr Hospital

Bryn Mawr, Pennsylvania, 19010, United States

RECRUITING

Pocono Medical Center

East Stroudsburg, Pennsylvania, 18301, United States

RECRUITING

UPMC Hillman Cancer Center Erie

Erie, Pennsylvania, 16505, United States

RECRUITING

UPMC Cancer Centers - Arnold Palmer Pavilion

Greensburg, Pennsylvania, 15601, United States

RECRUITING

UPMC Pinnacle Cancer Center/Community Osteopathic Campus

Harrisburg, Pennsylvania, 17109, United States

RECRUITING

Lehigh Valley Hospital-Hazleton

Hazleton, Pennsylvania, 18201, United States

RECRUITING

UPMC Hillman Cancer Center at Rocco And Nancy Ortenzio Cancer Pavilion

Mechanicsburg, Pennsylvania, 17050, United States

RECRUITING

Riddle Memorial Hospital

Media, Pennsylvania, 19063, United States

RECRUITING

UPMC Hillman Cancer Center - Monroeville

Monroeville, Pennsylvania, 15146, United States

RECRUITING

Paoli Memorial Hospital

Paoli, Pennsylvania, 19301, United States

RECRUITING

Thomas Jefferson University Hospital

Philadelphia, Pennsylvania, 19107, United States

RECRUITING

University of Pittsburgh Cancer Institute (UPCI)

Pittsburgh, Pennsylvania, 15232, United States

RECRUITING

Reading Hospital

West Reading, Pennsylvania, 19611, United States

RECRUITING

Lankenau Medical Center

Wynnewood, Pennsylvania, 19096, United States

RECRUITING

Prisma Health Cancer Institute - Spartanburg

Boiling Springs, South Carolina, 29316, United States

RECRUITING

Prisma Health Cancer Institute - Easley

Easley, South Carolina, 29640, United States

RECRUITING

Gibbs Cancer Center-Gaffney

Gaffney, South Carolina, 29341, United States

RECRUITING

Tidelands Georgetown Memorial Hospital

Georgetown, South Carolina, 29440, United States

RECRUITING

Prisma Health Cancer Institute - Butternut

Greenville, South Carolina, 29605, United States

RECRUITING

Prisma Health Cancer Institute - Faris

Greenville, South Carolina, 29605, United States

RECRUITING

Prisma Health Cancer Institute - Eastside

Greenville, South Carolina, 29615, United States

RECRUITING

Prisma Health Cancer Institute - Greer

Greer, South Carolina, 29650, United States

RECRUITING

Gibbs Cancer Center-Pelham

Greer, South Carolina, 29651, United States

RECRUITING

Prisma Health Cancer Institute - Seneca

Seneca, South Carolina, 29672, United States

RECRUITING

Spartanburg Medical Center

Spartanburg, South Carolina, 29303, United States

RECRUITING

SMC Center for Hematology Oncology Union

Union, South Carolina, 29379, United States

RECRUITING

Sanford Cancer Center Oncology Clinic

Sioux Falls, South Dakota, 57104, United States

RECRUITING

Sanford USD Medical Center - Sioux Falls

Sioux Falls, South Dakota, 57117-5134, United States

RECRUITING

Baptist Memorial Hospital and Cancer Center-Collierville

Collierville, Tennessee, 38017, United States

RECRUITING

Baptist Memorial Hospital and Cancer Center-Memphis

Memphis, Tennessee, 38120, United States

RECRUITING

Hematology Oncology Associates of Fredericksburg Inc

Fredericksburg, Virginia, 22408, United States

RECRUITING

Centra Alan B Pearson Regional Cancer Center

Lynchburg, Virginia, 24501, United States

RECRUITING

Virginia Cancer Institute

Richmond, Virginia, 23229, United States

RECRUITING

VCU Community Memorial Health Center

South Hill, Virginia, 23970, United States

RECRUITING

Swedish Cancer Institute-Edmonds

Edmonds, Washington, 98026, United States

RECRUITING

Swedish Cancer Institute-Issaquah

Issaquah, Washington, 98029, United States

RECRUITING

Swedish Medical Center-First Hill

Seattle, Washington, 98122, United States

RECRUITING

Edwards Comprehensive Cancer Center

Huntington, West Virginia, 25701, United States

RECRUITING

Langlade Hospital and Cancer Center

Antigo, Wisconsin, 54409, United States

RECRUITING

Duluth Clinic Ashland

Ashland, Wisconsin, 54806, United States

RECRUITING

Saint Vincent Hospital Cancer Center Green Bay

Green Bay, Wisconsin, 54301, United States

RECRUITING

Saint Vincent Hospital Cancer Center at Saint Mary's

Green Bay, Wisconsin, 54303, United States

RECRUITING

Gundersen Lutheran Medical Center

La Crosse, Wisconsin, 54601, United States

RECRUITING

Aspirus Medford Hospital

Medford, Wisconsin, 54451, United States

RECRUITING

ProHealth D N Greenwald Center

Mukwonago, Wisconsin, 53149, United States

RECRUITING

ProHealth Oconomowoc Memorial Hospital

Oconomowoc, Wisconsin, 53066, United States

RECRUITING

Saint Vincent Hospital Cancer Center at Oconto Falls

Oconto Falls, Wisconsin, 54154, United States

RECRUITING

Aspirus Cancer Care - James Beck Cancer Center

Rhinelander, Wisconsin, 54501, United States

RECRUITING

Saint Vincent Hospital Cancer Center at Sheboygan

Sheboygan, Wisconsin, 53081, United States

RECRUITING

Sheboygan Physicians Group

Sheboygan, Wisconsin, 53081, United States

RECRUITING

Aspirus Cancer Care - Stevens Point

Stevens Point, Wisconsin, 54481, United States

RECRUITING

Saint Vincent Hospital Cancer Center at Sturgeon Bay

Sturgeon Bay, Wisconsin, 54235-1495, United States

RECRUITING

UW Cancer Center at ProHealth Care

Waukesha, Wisconsin, 53188, United States

RECRUITING

Aspirus Regional Cancer Center

Wausau, Wisconsin, 54401, United States

RECRUITING

Aspirus Cancer Care - Wisconsin Rapids

Wisconsin Rapids, Wisconsin, 54494, United States

RECRUITING

MeSH Terms

Conditions

Carcinoma, Non-Small-Cell LungLung Neoplasms

Interventions

Specimen HandlingdurvalumabImmunoglobulin GDisulfidesWatchful WaitingObservation

Condition Hierarchy (Ancestors)

Carcinoma, BronchogenicBronchial NeoplasmsRespiratory Tract NeoplasmsThoracic NeoplasmsNeoplasms by SiteNeoplasmsLung DiseasesRespiratory Tract Diseases

Intervention Hierarchy (Ancestors)

Clinical Laboratory TechniquesDiagnostic Techniques and ProceduresDiagnosisInvestigative TechniquesImmunoglobulin IsotypesAntibodiesImmunoglobulinsImmunoproteinsBlood ProteinsProteinsAmino Acids, Peptides, and ProteinsSerum GlobulinsGlobulinsSulfidesAnionsIonsElectrolytesInorganic ChemicalsHydrogen SulfideSulfur CompoundsOrganic ChemicalsOutcome Assessment, Health CareOutcome and Process Assessment, Health CareQuality of Health CareHealth Services AdministrationMethods

Study Officials

  • Jeremy P Cetnar

    SWOG Cancer Research Network

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
interventional
Phase
phase 3
Allocation
RANDOMIZED
Masking
NONE
Purpose
TREATMENT
Intervention Model
PARALLEL
Sponsor Type
NIH
Responsible Party
SPONSOR

Study Record Dates

First Submitted

July 10, 2024

First Posted

July 12, 2024

Study Start

April 1, 2025

Primary Completion (Estimated)

July 15, 2039

Study Completion (Estimated)

July 15, 2039

Last Updated

April 14, 2026

Record last verified: 2026-04

Data Sharing

IPD Sharing
Will share

NCI is committed to sharing data in accordance with NIH policy. For more details on how clinical trial data is shared, access the link to the NIH data sharing policy page.

More information

Locations