High Altitude (HA) Residents With High Altitude Pulmonary Hypertension (HAPH), Pulmonary Artery Pressure (PAP) Assessed at HA (3200 m) vs LA (760 m)

NCT06489704 | Completed

• 1 other identifier: HAPH_HAvsLA_PAP
• Study Type: interventional
• Target: 24
• Locations: 1 country
• Sites: 1

Brief Summary

To study the effect of relocation from 3200 m (Aksay) to 760 m (Bishkek) in patients with high altitude pulmonary hypertension (HAPH) who permanently live \>2500 m on pulmonary artery pressure (PAP)

Conditions

High Altitude Pulmonary Hypertension

Keywords

Pulmonary Hypertension; Hypoxia; High Altitude; Pulmonal Arterial Pressure

Outcome Measures

Primary Outcomes (1)

• Change in Pulmonary artery Pressure (PAP) after the first night at 760 m (LA) vs at 3200 m (HA)

  Change in RV/RA in mmHg assessed by echocardiography between LA (760 m) vs High altitude (3200 m)

  day 2 at 760 m vs. 3200 m

Secondary Outcomes (11)

• Change in Pulmonary artery Pressure (PAP) after seven nights at 760 m (LA) vs at 3200 m (HA)

  day 7 at 760 m vs. 3200 m

• Cardiac output at 760 m (LA) vs at 3200 m (HA)

  day 2 and 7 at 760 m vs. 3200 m

• Tricuspid pressure gradient by echocardiography at 760 m (LA) vs at 3200 m (HA)

  day 2 and 7 at 760 m vs. 3200 m

• Tricupsid annular plane systolic excursion by echocardiography at 760 m (LA) vs at 3200 m (HA)

  day 2 and 7 at 760 m vs. 3200 m

• pH by arterial blood gases at 760 m (LA) vs at 3200 m (HA)

  day 2 and 7 at 760 m vs. 3200 m

Study Arms (1)

Assessments at 3200 m and 760 m, respectively

EXPERIMENTAL

Participants will have a echocardiography near their resident altitude at 3200 m and after relocation to 760 m after 1 and 7 days

Other: Echocardiography

Interventions

Echocardiography OTHER

Echocardiography will be performed according to clinical standards

Assessments at 3200 m and 760 m, respectively

Eligibility Criteria

• Age: 18 Years - 80 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Permanently living \>2500 m
• HAPH diagnosed with a minimum RV/RA of 30 mmHg assessed by echocardiography at an altitude of 3200 m
• Written informed consent

You may not qualify if:

• Highlanders who cannot follow the study investigations,
• Patients with moderate to severe concomitant lung disease (FEV1\<70% or forced vital capacity \<70%), severe parenchymal lung disease, heavy smoking \>20 cigarettes/day or \>20 pack-years.
• Coexistent unstable systemic hypertension or coronary artery disease that required adjustment of medication within the last 2 months
• Regular use of medication that affects control of breathing (benzodiazepines, opioids, acetazolamide)

Sponsors & Collaborators

• University of Zurich: lead

Study Sites (1)

Aksay Medical Center

Aksay Plateau, Naryn, Kyrgyzstan, Kyrgyzstan, Kyrgyzstan

Location

MeSH Terms

Conditions

Pulmonary edema of mountaineers; Hypertension, Pulmonary; Hypoxia; Altitude Sickness

Condition Hierarchy (Ancestors)

Lung Diseases; Respiratory Tract Diseases; Hypertension; Vascular Diseases; Cardiovascular Diseases; Signs and Symptoms, Respiratory; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Respiration Disorders

Study Officials

• Talant M Sooronbaev, Prof. Dr.

  National Center of Cardiology and Internal Medicine named after academician M.Mirrakhimov

  PRINCIPAL INVESTIGATOR

• Silvia Ulrich, Prof. Dr.

  University Hospital Zurich, Department of Pulmonology

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: OTHER
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Model Details: Each highlander with HAPH will perform a echocardiography at high altitude (HA, 3200 m) and day 2 and day 7 at low altitude (LA, 760 m) according to a prospective study design

Study Record Dates

• First Submitted: June 28, 2024
• First Posted: July 8, 2024
• Study Start: July 2, 2024
• Primary Completion: September 27, 2024
• Study Completion: September 27, 2024
• Last Updated: January 21, 2026

Record last verified: 2026-01

Locations

KY (1)