Right Ventricular Function at Rest in Highlanders/Lowlanders

NCT03165656 | Completed

• 1 other identifier: 01-8/433A
• Study Type: observational
• Target: 173
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of the current study is to evaluate the progression of right ventricular function and dimension in Kyrgyz highlanders with high altitude pulmonary hypertension (HAPH) by performing a cross sectional case-control study.

Conditions

High Altitude Pulmonary Hypertension

Keywords

Echocardiography; right ventricular function; pulmonary hypertension; disease progression; hypoxia

Outcome Measures

Primary Outcomes (1)

• Pulmonary artery pressure

  Difference between highlanders with pulmonary hypertension, healthy highlanders and healthy lowlanders in tricuspid pressure gradient, measured by transthoracic echocardiography

  Day 2

Secondary Outcomes (5)

• cardiac output

  Day 2

• right heart dimensions

  Day 2

• Right heart function

  Day 2

• stroke volume

  Day 2

• volumes

  Day 2

Study Arms (3)

High altitude pulmonary hypertension

Highlanders with high altitude pulmonary hypertension living above 2500 m.

High altitude control

Healthy highlanders living above 2500 m.

Low altitude control

Healthy lowlanders living below 1000 m.

Eligibility Criteria

• Age: 16 Years+
• Sex: all
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Highlanders with high altitude pulmonary hypertension living at an altitude of 2500-4000 m; healthy highlanders living at an altitude of 2500-4000 m; healthy lowlanders living at an altitude of \<1000 m.

You may qualify if:

• high altitude pulmonary hypertension confirmed by clinical presentation and mean pulmonary artery pressure \>30 mmHg measured by echocardiography at altitude of residence.
• healthy subjects (high altitude controls)
• Both genders
• Age \>16 y
• Kyrgyz ethnicity
• born, raised and currently living at \>2500 m
• healthy subjects currently living at \<1000 m (low altitude controls)

You may not qualify if:

• Pulmonary hypertension from other causes, in particular from left ventricular failure as judged clinically and by echocardiography
• Excessive erythrocytosis
• Other coexistent disorders that may interfere with the cardio-respiratory system and sleep
• Regular use of medication that affects control of breathing
• Heavy smoking

Sponsors & Collaborators

• University of Zurich: lead
• National Center of Cardiology and Internal Medicine named after academician M.Mirrakhimov: collaborator

Study Sites (1)

National Center for Cardiology and Internal Medicine

Bishkek, 720040, Kyrgyzstan

Location

Related Publications (1)

• Gosens R, Hiemstra PS, Adcock IM, Bracke KR, Dickson RP, Hansbro PM, Krauss-Etschmann S, Smits HH, Stassen FRM, Bartel S. Host-microbe cross-talk in the lung microenvironment: implications for understanding and treating chronic lung disease. Eur Respir J. 2020 Aug 20;56(2):1902320. doi: 10.1183/13993003.02320-2019. Print 2020 Aug.

  PMID: 32430415 DERIVED

MeSH Terms

Conditions

Pulmonary edema of mountaineers; Hypertension, Pulmonary; Disease Progression; Hypoxia

Condition Hierarchy (Ancestors)

Lung Diseases; Respiratory Tract Diseases; Hypertension; Vascular Diseases; Cardiovascular Diseases; Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Signs and Symptoms, Respiratory; Signs and Symptoms

Study Officials

• Talant M Sooronbaev, MD

  National Center of Cardiology and Internal Medicine, Bishkek, Kyrgyzstan

  STUDY CHAIR

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: PROSPECTIVE
• Target Duration: 3 Days
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Prof. Dr.

Study Record Dates

• First Submitted: May 23, 2017
• First Posted: May 24, 2017
• Study Start: May 24, 2017
• Primary Completion: August 16, 2017
• Study Completion: August 16, 2017
• Last Updated: August 16, 2019

Record last verified: 2019-08

Locations

KY (1)