Right Ventricular Function During Exercise in Highlanders/Lowlanders

NCT03165032 | Completed

• 1 other identifier: 01-8/433B
• Study Type: observational
• Target: 173
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of the current study is to evaluate the right ventricular function during graded cycling on an ergometer by transthoracic echocardiography in Kyrgyz highlanders with high altitude pulmonary hypertension (HAPH) by performing a cross-sectional case-control study.

Conditions

High Altitude Pulmonary Hypertension

Keywords

exercise; echocardiography; right ventricular function; pulmonary hypertension; hypoxia

Outcome Measures

Primary Outcomes (1)

• pulmonary artery pressure (PAP) during exercise

  Difference in change of tricuspid pressure gradient during exercise between highlanders with pulmonary hypertension, healthy highlanders and healthy lowlanders, measured by transthoracic echocardiography during graded cycling on an ergometer

  Day 2

Secondary Outcomes (3)

• cardiac output (CO) during exercise

  Day 2

• PAP/CO slope during exercise

  Day 2

• Oxygen saturation

  Day 2

Study Arms (3)

High altitude pulmonary hypertension

Highlanders with high altitude pulmonary hypertension living above 2500 m.

High altitude control

Healthy highlanders living above 2500 m.

Low altitude control

Healthy lowlanders living below 1000 m.

Eligibility Criteria

• Age: 16 Years+
• Sex: all
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Highlanders with high altitude pumonary hypertension living at an altitude of 2500-4000 m; healthy highlanders living at an altitude of 2500-4000 m; healthy lowlanders living at an altitude of \<1000 m.

You may qualify if:

• high altitude pulmonary hypertension confirmed by clinical presentation and mean pulmonary artery pressure \>30 mmHg measured by echocardiography at altitude of residence.
• healthy subjects (high altitude controls)
• Both genders
• Age \>16 y
• Kyrgyz ethnicity
• born, raised and currently living at \>2500 m
• healthy subjects currently living at \<1000 m (low altitude controls)

You may not qualify if:

• Pulmonary hypertension from other causes, in particular from left ventricular failure as judged clinically and by echocardiography
• Excessive erythrocytosis
• Other coexistent disorders that may interfere with the cardio-respiratory system and sleep
• Regular use of medication that affects control of breathing
• Heavy smoking

Sponsors & Collaborators

• University of Zurich: lead
• National Center of Cardiology and Internal Medicine named after academician M.Mirrakhimov: collaborator

Study Sites (1)

National Center for Cardiology and Internal Medicine

Bishkek, 720040, Kyrgyzstan

Location

MeSH Terms

Conditions

Pulmonary edema of mountaineers; Motor Activity; Hypertension, Pulmonary; Hypoxia

Condition Hierarchy (Ancestors)

Behavior; Lung Diseases; Respiratory Tract Diseases; Hypertension; Vascular Diseases; Cardiovascular Diseases; Signs and Symptoms, Respiratory; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: PROSPECTIVE
• Target Duration: 3 Days
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Prof. Dr.

Study Record Dates

• First Submitted: May 22, 2017
• First Posted: May 24, 2017
• Study Start: May 24, 2017
• Primary Completion: August 16, 2017
• Study Completion: August 16, 2017
• Last Updated: August 16, 2019

Record last verified: 2019-08

Locations

KY (1)