NCT06485479

Brief Summary

The main purpose of this trial is to identify effective quit smoking ads for people who smoke menthol cigarettes. Investigators will conduct an online randomized trial with a nationally representative sample of \~1,400 US adults (ages 21+) who smoke menthol cigarettes.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
1,236

participants targeted

Target at P75+ for not_applicable

Timeline
Completed

Started Sep 2024

Shorter than P25 for not_applicable

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

June 26, 2024

Completed
7 days until next milestone

First Posted

Study publicly available on registry

July 3, 2024

Completed
2 months until next milestone

Study Start

First participant enrolled

September 5, 2024

Completed
2 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

October 21, 2024

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

October 21, 2024

Completed
1 year until next milestone

Results Posted

Study results publicly available

November 3, 2025

Completed
Last Updated

November 3, 2025

Status Verified

October 1, 2025

Enrollment Period

2 months

First QC Date

June 26, 2024

Results QC Date

October 21, 2025

Last Update Submit

October 21, 2025

Conditions

Outcome Measures

Primary Outcomes (1)

  • Perceived Message Effectiveness for Motivation

    Perceived effectiveness of the ads at encouraging quitting smoking, measured by 1 survey item for each ad (6 items total). Range 1 to 5, with higher values indicating higher perceived message effectiveness.

    During exposure to the ads, assessed during one-time online 15-minute survey.

Secondary Outcomes (5)

  • Perceived Message Effectiveness for Response Efficacy

    During exposure to the ads, assessed during one-time online 15-minute survey.

  • Perceived Message Effectiveness for Self-efficacy

    During exposure to the ads, assessed during one-time online 15-minute survey.

  • Intentions to Quit Smoking

    After exposure to the ads, assessed during one-time online 15-minute survey.

  • Response Efficacy

    After exposure to the ads, assessed during one-time online 15-minute survey.

  • Self-efficacy

    After exposure to the ads, assessed during one-time online 15-minute survey.

Study Arms (5)

Ads about response efficacy for quitting smoking

EXPERIMENTAL

Participants will view ads designed to increase response efficacy for quitting cigarettes.

Behavioral: Intervention ads

Ads about self-efficacy for quitting smoking

EXPERIMENTAL

Participants will view ads designed to increase self-efficacy to quit smoking.

Behavioral: Intervention ads

Ads about motivation to quit smoking

EXPERIMENTAL

Participants will view ads designed to increase motivation to quit smoking.

Behavioral: Intervention ads

Ads about reading

OTHER

Participants will view non-smoking related ads on the benefits of reading.

Behavioral: Control ads

Ads about passwords

OTHER

Participants will view non-smoking related ads on passwords.

Behavioral: Control ads

Interventions

The ads will be on topics to encourage quitting smoking, formatted as multi-color text with graphic elements. Trial investigators developed the ads and optimized them to be readable when delivered in an SMS text message.

Ads about motivation to quit smokingAds about response efficacy for quitting smokingAds about self-efficacy for quitting smoking
Control adsBEHAVIORAL

The ads will be on topics unrelated to quitting smoking, formatted as black text on a white field. Trial investigators developed the ads and optimized them to be readable when delivered in an SMS text message.

Ads about passwordsAds about reading

Eligibility Criteria

Age21 Years+
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64), Older Adult (65+)

You may not qualify if:

  • Currently smoke menthol cigarettes
  • Be a member of the AmeriSpeak online survey panel or their convenience sample
  • Live in the US
  • Be age 21 years or older
  • Read and speak English
  • Not currently smoke menthol cigarettes
  • Not be a member of the AmeriSpeak online survey panel or their convenience sample
  • Not live in the US
  • Be younger than age 21 years
  • Not be able to read and speak English

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

University of North Carolina

Chapel Hill, North Carolina, 27599, United States

Location

Related Links

MeSH Terms

Conditions

Smoking

Condition Hierarchy (Ancestors)

Behavior

Results Point of Contact

Title
Principal Investigator
Organization
UNC

Study Officials

  • Noel Brewer, PhD

    University of North Carolina, Chapel Hill

    PRINCIPAL INVESTIGATOR
  • Marissa G Hall, PhD

    University of North Carolina, Chapel Hill

    PRINCIPAL INVESTIGATOR

Publication Agreements

PI is Sponsor Employee
No
Restrictive Agreement
No

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
NONE
Purpose
PREVENTION
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

June 26, 2024

First Posted

July 3, 2024

Study Start

September 5, 2024

Primary Completion

October 21, 2024

Study Completion

October 21, 2024

Last Updated

November 3, 2025

Results First Posted

November 3, 2025

Record last verified: 2025-10

Data Sharing

IPD Sharing
Will share

The trial investigators will produce a de-identified dataset and codebook for sharing with external investigators, making use of the UNC Dataverse digital data repository (dataverse.unc.edu) hosted by the Odum Institute Data Archive.

Shared Documents
SAP
Time Frame
The data will be available beginning 12 and continuing for 36 months following the primary publication.
Access Criteria
To obtain a copy of the dataset and codebook, a research scientist will submit a request in writing, identifying themselves and their affiliated institution, indicating what they plan to do with the data, and including assurances that they will not share the data with others without the written permission of the PI. Requestors must already have institutional review board, independent ethics committee, or research ethics board approval, as applicable. Requestors must obtain a data use agreement through UNC's Office of Industry Contracting (OIC@unc.edu) to receive the dataset and codebook and agree to acknowledge NIH and the study investigators in any publications resulting from the data.

Locations