Effect of Oral pH Changes on Smoking Desire

NCT04032236 | Completed

• 1 other identifier: 437-SBKAEK
• Study Type: interventional
• Target: 82
• Locations: 1 country
• Sites: 1

Brief Summary

Nicotine is a psychoactive substance and its effect is demonstrated by neuronal nicotinic-acetylcholine receptors excreted in the brain and periphery. Psychoactive substances such as nicotine and caffeine play a role in rewarding through the mesolimbic dopaminergic system. The released dopamine produces pharmacological effects that can cause pleasurable emotions. These effects are an important factor in maintaining smoking motivation. The rate of absorption of nicotine from the buccal mucosa, the rate and amount of dependence, significantly affects the risk. In addition to PH, other factors such as local blood flow, product nematode, size and surface area of the tobacco mixture, constant pH holding capacity, and nicotine content of the tobacco can affect nicotine absorption. To facilitate the absorption of nicotine from the buccal mucosa, various substances that increase absorption have been investigated. Increased alkalinity has been shown to increase nicotine absorption and physiological effects by buffering alkaline pH values with moist snuff products and nicotine gums. Although other factors may affect the nicotine absorption rate in oral tobacco, it is stated that the main factor that determines the rate of nicotine absorption is pH. Factors that trigger nicotine use include stress in daily life, daily routines, eating and drinking habits, and especially the use of caffeine. The chronic use of caffeine causes tolerance in many of its effects, and the use of nicotine reduces tolerance effects and also potentiates the effects stimulated through the dopaminergic pathway. It has been reported that smokers consume more caffeine than non-smokers. In the present study, the relationship between oral pH and cigarette demand after caffeine consumption will be investigated. Until now, the relation between cigarette pre- and post-caffeine saliva pH and cigarette smoking has not been investigated. In addition, the effects of drinking behavior and changes in salivary pH on cigarette desire will be investigated and evidence of behavioral methods applied in cigarette smoking cessation treatment will be provided.

Conditions

Smoking Behaviors

Keywords

caffeine; nicotin; pH

Outcome Measures

Primary Outcomes (1)

• To investigate the changes in salivary pH after coffee consumption

  salivary pH measurement

  30 minutes after intervention

Secondary Outcomes (1)

• to investigate how drinking of water affect the smoking desire

  30 minutes after intervention

Study Arms (2)

smoking group

OTHER

35 smoking case

Other: caffeine

nonsmoking group

OTHER

35 nonsmoking case

Other: caffeine

Interventions

caffeine OTHER

At room temperature (18-25 ° C) the same place and standard environment will be done. All involved cases will undergo a dental examination and within 30 minutes three samples of saliva will be taken, including first sample, after coffee drink and after drinking water. The pH of samples will be measured and the smoking cessation rate of the smoking cigarette smoker with simultaneous VAS (VISUAL ANALOG SCALA) will be measured. This data will be compared in-house and non-smoking control group

Also known as: water

nonsmoking group; smoking group

Eligibility Criteria

• Age: 18 Years - 45 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Not having an active disease
• Be between the ages of 18 and 45
• Not using antibiotics in the last two weeks
• Do not use inhaler treatments
• Not to have an oral or salivary gland disease
• One week after menstrual bleeding in female cases
• At least 10 pack years (P / Y) cigarette story in the case group

You may not qualify if:

• Being an active disease
• \<18 years and\> 45 years old
• Having used antibiotics in the last two weeks
• Use inhaler treatments
• Oral and salivary gland disease
• One week after menstrual bleeding in female cases
• Being in the luteal phase
• Menstrual irregularity
• Being pregnant
• Taking hormonal treatment

Sponsors & Collaborators

• Dokuz Eylul University: lead

Study Sites (1)

Dokuz Eylul University

Izmir, 35340, Turkey (Türkiye)

Location

MeSH Terms

Conditions

Smoking

Interventions

Caffeine; Water

Condition Hierarchy (Ancestors)

Behavior

Intervention Hierarchy (Ancestors)

Xanthines; Alkaloids; Heterocyclic Compounds; Purinones; Purines; Heterocyclic Compounds, 2-Ring; Heterocyclic Compounds, Fused-Ring; Hydroxides; Alkalies; Inorganic Chemicals; Anions; Ions; Electrolytes; Oxides; Oxygen Compounds

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NON RANDOMIZED
• Masking: NONE
• Purpose: OTHER
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Associate Professor, MD

Model Details: case-control

Study Record Dates

• First Submitted: July 19, 2019
• First Posted: July 25, 2019
• Study Start: June 1, 2018
• Primary Completion: January 31, 2019
• Study Completion: January 31, 2019
• Last Updated: July 26, 2019

Record last verified: 2019-07

Locations

TU (1)