Correlation Analysis of POD and pNCD in Elderly Spinal Surgery Patients

NCT06466083 | Recruiting

• 1 other identifier: 19880416
• Study Type: observational
• Target: 165
• Locations: 1 country
• Sites: 1

Brief Summary

This study is a prospective cohort study to investigate the differences in serum indexes between elderly spinal surgery patients with postoperative delirium (POD) who either develop or do not develop long-term postoperative neurocognitive disorders (pNCD).

Conditions

Postoperative Delirium; Postoperative Neurocognitive Disorder; Spinal Surgery

Keywords

postoperative delirium; postoperative neurocognitive disorder; serum indexes; spinal surgery

Outcome Measures

Primary Outcomes (1)

• change in serum indexes between elderly spinal patients with postoperative delirium(POD) who either develop or do not develop postoperative neurocognitive disorders (pNCD) one month after surgery

  Perioperative neurocognitive disorders (PND) represent one of the common complications of general anesthesia, posing serious hazards and currently being a hot topic and a challenging problem in international research. Recently, general anesthesia has led to a new breakthrough in the study of PND serum-related markers, such as brain-derived nutritional factors(BDNF)、C-reactive protein(CRP)、homocysteine(Hcy). This provides new perspectives for PND prevention, evaluation and furnishes theoretical grounds for enhancing the safety of clinical anesthesia and the quality of life for patients.

  2024.5.9-2026.5.1

Study Arms (1)

postoperative delirium(POD) and postoperative neurocognitive disorder(pNCD)

Delirium (CAM scale ) was assessed 7 days after surgery and divided into POD and non-POD groups; one of the above scenarios indicated postoperative delirium;The patients in the POD group were evaluated for cognitive function at 1 month and 12 months after surgery to determine whether pNCD occurred. The patients in the POD group were further divided into pNCD subgroup and non-PNCD subgroup, and serum indexes were compared

Other: no intervention

Interventions

no intervention OTHER

this is an observation study,no intervention

postoperative delirium(POD) and postoperative neurocognitive disorder(pNCD)

Eligibility Criteria

• Age: 65 Years - 100 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Patients 65\~100 years of age who have undergone spinal surgical anesthesia

You may qualify if:

• Patients ≥65 years of age who have undergone spinal surgery anesthesia; Sign informed consent

You may not qualify if:

• Inability to complete cognitive function assessment; Illiteracy, hearing impairment or visual impairment; He has a history of epilepsy, depression, schizophrenia, Alzheimer's disease and other psychiatric and neurological diseases

Sponsors & Collaborators

• Xuanwu Hospital, Beijing: lead

Study Sites (1)

Xuanwu Hospital, Capital Medical University, Beijing, 100053

Beijing, China

RECRUITING

MeSH Terms

Conditions

Emergence Delirium

Condition Hierarchy (Ancestors)

Delirium; Confusion; Neurobehavioral Manifestations; Neurologic Manifestations; Nervous System Diseases; Postoperative Complications; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Signs and Symptoms; Neurocognitive Disorders; Mental Disorders

Central Study Contacts

lei zhao

CONTACT

+8613811035886; zhaoalei@sina.com

ke cui

CONTACT

+8613671393294; 15911031500@163.com

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Target Duration: 1 Year
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: May 29, 2024
• First Posted: June 20, 2024
• Study Start: January 14, 2025
• Primary Completion (Estimated): July 1, 2026
• Study Completion (Estimated): July 1, 2026
• Last Updated: April 3, 2025

Record last verified: 2025-03

Data Sharing

• IPD Sharing: Will not share

Locations

CN (1)