Beijing Disability Risk and Ageing Monitoring Study

NCT06394817 | Recruiting

• 1 other identifier: 2022234
• Study Type: observational
• Target: 2,000
• Locations: 1 country
• Sites: 1

Brief Summary

This is a community-based prospective cohort study in Beijing, China. The study has been initialized in 2023 and enrolled older residents. This study aims to develop disability risk assessment standards and an early warning model for older adults.

Conditions

Age Problem; Disability; Death

Keywords

Disability, Ageing, Cohort

Outcome Measures

Primary Outcomes (8)

• The prevalence and incidence of functional disability using a population-based survey

  Functional disability was measured by Activities of Daily Living, cognitive function (Mini-Mental State Examination) and movement disorder（Short Physical Performance Battery) collected by questionnaires.The minimum value of the Activities of Daily Living is 0, and the maximum value is 100, the higher the score, the better the outcome.The minimum value of the Mini-Mental State Examination is 0, and the maximum value is 30, the higher the score, the better the outcome.The minimum value of the Short Physical Performance Battery is 0, and the maximum value is 12, the higher the score, the better the outcome.

  An average of 1 to 2 years

• The prevalence and incidence of mild cognitive impairment using a population-based survey

  Mild cognitive impairment was measured using Mini-Mental State Examination collected by questionnaire.The minimum value of the Mini-Mental State Examination is 0, and the maximum value is 30, the higher the score, the better the outcome.

  An average of 1 to 2 years

• The prevalence and incidence of dementia using a population-based survey

  Dementia was determined by diagnosis of hospitalization or diagnosis of death or Clinical Dementia Rating scale. The minimum value of the Clinical Dementia Rating is 0, and the maximum value is 3, the higher the score, the worse the outcome.

  An average of 1 to 2 years

• The conversion rate of normal to mild cognitive impairment

  Percentage of enrolled population that convert from normal to mild cognitive impairment

  An average of 1 to 2 years

• The conversion rate of mild cognitive impairment to dementia

  Percentage of enrolled population that convert from mild cognitive impairment to dementia

  An average of 1 to 2 years

• The genetic and environmental factors for mild cognitive impairment and dementia at genomic and expression levels

  Discover risk factors including genetic susceptibility loci (APOE genes and other risk genes) using gene sequencing, cardiovascular risk factors (blood glucose, cholesterol, homocysteine) using laboratory tests, and unhealthy lifestyle using questionnaire.

  An average of 1 to 2 years

• The biomarkers for normal, mild cognitive impairment, and dementia diagnosis

  Humoral biomarkers are included Aβ42, Aβ40, phosphated tau and total tau in plasma, cerebrospinal fluid, saliva, and urine. Imaging biomarkers are included cerebral volume, glucose metabolism, amyloid and tau deposition of whole brain or hippocampus.

  An average of 1 to 2 years

• The prevalence and incidence of movement disorder using a population-based survey

  Movement disorder was measured using Short Physical Performance Battery collected by questionnaire.The minimum value of the Short Physical Performance Battery is 0, and the maximum value is 12, the higher the score, the better the outcome.

  An average of 1 to 2 years

Study Arms (1)

Total

All subjects

Other: No intervention

Interventions

No intervention OTHER

No intervention

Total

Eligibility Criteria

• Age: 60 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Community residents aged 60 years or older in China

You may qualify if:

• Aged 60 years or older
• Lived in the community for more than 1 year
• Signed the informed consent form

You may not qualify if:

• Cannot complete the survey

Sponsors & Collaborators

• Xuanwu Hospital, Beijing: lead

Study Sites (1)

Xuanwu Hospital, Capital Medical University

Beijing, 100053, China

RECRUITING

Biospecimen

Retention: SAMPLES WITH DNA

Plan to obtain blood samples from some of the participants

MeSH Terms

Conditions

Death

Condition Hierarchy (Ancestors)

Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Officials

• Yi Tang, MD., PhD

  Xuanwu Hospital, Beijing

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Yi Tang, MD., PhD

CONTACT

00861083199456; tangyi@xwhosp.org

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: April 16, 2024
• First Posted: May 1, 2024
• Study Start: February 20, 2023
• Primary Completion (Estimated): May 1, 2063
• Study Completion (Estimated): May 1, 2063
• Last Updated: June 20, 2024

Record last verified: 2024-04

Locations

CN (1)