Emotional Attention Bias Modification and Targeted Memory Reactivation in Alcohol Use Disorder

NCT06457113 | Not Yet Recruiting

• 1 other identifier: MZhao-018
• Study Type: interventional
• Target: 74
• Locations: 0 countries
• Sites: N/A

Brief Summary

Through this protocol, researchers examine whether Targeted Memory Reactivation (TMR), a technique used to enhance memory, can augment the control of craving levels in patients with Alcohol Use Disorder by enhancing positive emotional attention bias modification.

Conditions

Alcohol Use Disorder

Outcome Measures

Primary Outcomes (1)

• Changes in behavioral indicators of positive emotional attention bias towards alcohol-related cues

  Positive emotional attention bias is assessed through emotional attention bias under electroencephalogram recording, with the indicator being D scores calculated from the response time (D alcohol=RT (negative) - RT (positive) )/SD negative+positive).

  baseline, 1 day after treatment, 2 weeks after treatment

Secondary Outcomes (3)

• Changes in behavioral indicators of positive emotional attention bias towards healthy activity cues

  baseline, 1 day after treatment, 2 weeks after treatment

• Change of Craving assessed by Visual Analog Scale

  baseline, 1 day after treatment, 2 weeks after treatment

• Change of Craving assessed by Visual Analog Mood Scale

  baseline, 1 day after treatment, 2 weeks after treatment

Study Arms (2)

TMR group

EXPERIMENTAL

Patients will receive a sound S1 and sound S2 while they generate a correct outcome of Emotional Attention Bias Modification(EABM). They will also receive the sound S1 and sound S2 during REM sleep.

Behavioral: Emotional Attention Bias Modification and Targeted memory reactivation during REM sleep

Control group

ACTIVE COMPARATOR

Patients will not receive the sound S1 and sound S2 while they generate a correct outcome of Emotional Attention Bias Modification(EABM). During REM sleep, they will receive the same sound as the experimental group (S1 and S2) under the same conditions.

Behavioral: Emotional Attention Bias Modification

Interventions

Emotional Attention Bias Modification and Targeted memory reactivation during REM sleep BEHAVIORAL

Emerging evidence shows that REM sleep is crucial for processing emotional memories and consolidating implicit memories. By using targeted memory reactivation (TMR), a known method where sound S1 and sound S2 are associated with a waking experience(i.e.negative emotional words is associated with alcohol-related cues and positive emotional words is associated with healthy lifestyle cues) and strengthened during REM sleep, the investigators aim to augment the control of craving levels in patients with Alcohol Use Disorder.

TMR group

Emotional Attention Bias Modification BEHAVIORAL

These patients will receive the treatment of emotional attention bias modification (EABM) without association with the sound S1 and sound S2.

Control group

Eligibility Criteria

• Age: 18 Years - 55 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64)

You may qualify if:

• Aged 18-55 years; Meets the diagnostic criteria for Alcohol Use Disorder according to the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) (American Psychiatric Association, 2013); Alcohol withdrawal period of less than 6 months; Normal vision and hearing, or corrected to normal; Agrees to participate in the study and is able to cooperate to complete the experiment.

You may not qualify if:

• Acute alcohol withdrawal period: Clinical Institute Withdrawal Assessment for Alcohol Scale (CIWA-Ar) score ≥ 9; History of organic brain diseases or brain trauma; History of seizures, other neuropsychiatric disorders, or family history of psychiatric disorders; Presence of substance abuse/addiction other than alcohol (excluding nicotine addiction).

Sponsors & Collaborators

• Shanghai Mental Health Center: lead

MeSH Terms

Conditions

Alcoholism

Condition Hierarchy (Ancestors)

Alcohol-Related Disorders; Substance-Related Disorders; Chemically-Induced Disorders; Mental Disorders

Study Officials

• Min Zhao

  Shanghai Mental Health Center

  STUDY CHAIR

Central Study Contacts

Min Zhao, PhD

CONTACT

021-54252689; drminzhao@gmail.com

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: PARTICIPANT, OUTCOMES ASSESSOR
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: June 8, 2024
• First Posted: June 13, 2024
• Study Start: June 30, 2024
• Primary Completion: June 30, 2025
• Study Completion: June 30, 2025
• Last Updated: June 13, 2024

Record last verified: 2024-06

Data Sharing

• IPD Sharing: Will not share