Postoperative BMI Changes and Functional Outcomes in Knee and Hip Arthroplasty

NCT06440863 | Completed DMC

• 1 other identifier: Y7MQG7gO
• Study Type: interventional
• Target: 459
• Locations: 1 country
• Sites: 1

Brief Summary

PURPOSE Obesity poses challenges to preoperative mobility and functional recovery for arthroplasty patients, yet postoperative weight loss remains elusive. This study aims to investigate postoperative weight changes and their impact on functional scores following knee and hip arthroplasty, exploring factors influencing these changes. METHODS A total of 459 knee and hip arthroplasty cases with a 2-year follow-up were analyzed. BMI and Oxford scores were tracked, alongside factors including comorbidities, corticosteroid use, physiotherapy, and unilateral vs. bilateral surgery. EXPECTED OUTCOMES Based on the study's design and the data available, we anticipate observing the impact of changes in patients' BMI on clinical scores as an independent variable. Additionally, we aim to elucidate the effects of comorbidities, corticosteroid use, physiatrist follow-up, and the type of surgical procedure on both BMI and clinical outcomes. Through this analysis, we expect to gain a comprehensive understanding of how these factors interplay to influence postoperative recovery and overall patient health.

Conditions

Arthropathy; Obesity

Keywords

Total Hip Arthroplasty; Total Knee Arthroplasty; Weight Loss; Obesity; Body Mass Index

Outcome Measures

Primary Outcomes (2)

• BMI

  Body Mass Index (BMI) is a person's weight in kilograms divided by the square of height in meters.

  2 years

• Oxford hip and knee scores

  It is scored between 0 and 48. 48 is the best function.

  2 years

Study Arms (2)

Total Knee Arthroplasty

ACTIVE COMPARATOR

Patients indicated for total knee arthroplasty.

Procedure: Total Knee Arthroplasty

Total Hip Arthroplasty

ACTIVE COMPARATOR

Patients indicated for total hip arthroplasty.

Procedure: Total Hip arthroplasty

Interventions

Total Knee Arthroplasty PROCEDURE

Patients undergoing total knee arthroplasty

Total Knee Arthroplasty

Total Hip arthroplasty PROCEDURE

Patients undergoing total hip arthroplasty

Total Hip Arthroplasty

Eligibility Criteria

• Age: 20 Years - 80 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Patients who underwent primary TKA and THA with a 2-year follow-up were included

You may not qualify if:

• Patients who underwent bariatric surgery before or after the surgery
• Incomplete 2-year follow-up
• Whom BMI or Oxford scores could not be accessed

Sponsors & Collaborators

• Istanbul University - Cerrahpasa: lead

Study Sites (1)

Istanbul University - Cerrahpasa, Cerrahpasa Faculty of Medicine

Istanbul, Fatih, 34098, Turkey (Türkiye)

Location

Related Publications (3)

• Woodruff MJ, Stone MH. Comparison of weight changes after total hip or knee arthroplasty. J Arthroplasty. 2001 Jan;16(1):22-4. doi: 10.1054/arth.2001.9826.

  PMID: 11172266 BACKGROUND

• Riddle DL, Singh JA, Harmsen WS, Schleck CD, Lewallen DG. Clinically important body weight gain following knee arthroplasty: a five-year comparative cohort study. Arthritis Care Res (Hoboken). 2013 May;65(5):669-77. doi: 10.1002/acr.21880.

  PMID: 23203539 BACKGROUND

• Inacio MC, Silverstein DK, Raman R, Macera CA, Nichols JF, Shaffer RA, Fithian D. Weight patterns before and after total joint arthroplasty and characteristics associated with weight change. Perm J. 2014 Winter;18(1):25-31. doi: 10.7812/TPP/13-082.

  PMID: 24626069 BACKGROUND

MeSH Terms

Conditions

Joint Diseases; Obesity; Weight Loss

Interventions

Arthroplasty, Replacement, Knee; Arthroplasty, Replacement, Hip

Condition Hierarchy (Ancestors)

Musculoskeletal Diseases; Overweight; Overnutrition; Nutrition Disorders; Nutritional and Metabolic Diseases; Body Weight; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Body Weight Changes

Intervention Hierarchy (Ancestors)

Arthroplasty, Replacement; Arthroplasty; Orthopedic Procedures; Surgical Procedures, Operative; Plastic Surgery Procedures; Prosthesis Implantation

Study Officials

• Cumhur Deniz Davulcu

  Istanbul University - Cerrahpasa

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Research Assistant

Study Record Dates

• First Submitted: May 27, 2024
• First Posted: June 4, 2024
• Study Start: January 1, 2018
• Primary Completion: December 30, 2022
• Study Completion: May 1, 2024
• Last Updated: June 4, 2024

Record last verified: 2024-06

Data Sharing

• IPD Sharing: Will share
• Shared Documents: STUDY PROTOCOL, SAP, ICF, CSR

Locations

TU (1)