Sources and Mechanisms of Energy Compensation

NCT06432517 | Recruiting

• 1 other identifier: SIAT-IRB-230515-H0653
• Study Type: interventional
• Target: 81
• Locations: 1 country
• Sites: 1

Brief Summary

Excess energy, obesity and obesity-related diseases are important global health issues. Although it is known that obesity is an issue of energy balance, the components of energy expenditure seem to be inter-related in complex non-additive ways. The aim of this study is to explore the downstream impacts of exercise on short term changes in both expenditure and energy intake. The primary question the investigators are asking is whether moderate to high intensity exercise influences the basal energy expenditure and/or energy intake/macronutrient preference in young adult males? (A similar study will be performed on females in a different registration). The investigators will use a specially designed feeding table to measure energy intake and macronutrient intake, which is easy to quantify intake compensation. Basal metabolism will be measured by hood indirect calorimetry. The investigators will explore the factors that influence the level of compensation in expenditure and intake, in particular body composition. Participants will be asked to come to the lab after 10 hours fast for body composition tests including Dual Energy X-ray Absorptiometry(DXA), Magnetic Resonance Image(MRI) and Bioelectrical Impedance Analysis(BIA). They will then be asked (not) to do 30 minutes of moderate-to-vigorous exercise after an energy-limiting breakfast, during which metabolic rate levels and changes in dietary composition will be recorded by gas exchange and standardized buffet. In addition, participants' subjective hunger and preferences will also be recorded by questionnaires. Venous blood will be collected to measure metabolic and hormone factors, blood glucose will be measured by Continuous Blood Glucose Monitor (CGM).

Conditions

Energy Expenditure; Exercise; Energy Intake; Food Preferences

Keywords

Energy compensation; Energy balance; Food Preferences

Outcome Measures

Primary Outcomes (3)

• Macronutrient preference

  Macronutrients preference will be recorded by the feeding table, macronutrient preference will be calculated in percentage(%).

  During lunchtime and dinnertime on both the control day(baseline) and exercise day(the day after control day), each test lasting for 40 minutes.

• Energy intake

  Response on standard feeding table, the food consumption will be recorded continuously by balances underneath each food dish. The total energy intake will be calculated in kilojoule (KJ).

  During lunchtime and dinnertime on both the control day(baseline) and exercise day(the day after control day), each test lasting for 40 minutes.

• Basal metabolic rate

  Resting energy expenditure will be measured using indirect calorimetry via a respiratory hood system (Cosmed). The subject attends in the lab after an overnight fast. The person lies down on a flat bed and the hood is placed over their head. Metabolic rate (oxygen consumption and carbon dioxide production) are monitored for 40 minutes. The last 10 minutes is used as the measurement. Calorimeters will be assessed with a turbine test to ensure accuracy of measurements. Validation via an alcohol burn will be performed monthly.

  The detection time spans over two days, the control day and the exercise day, from 8:00 am to 5:00 pm, with tests being conducted every hour and each test lasting for half an hour.

Secondary Outcomes (15)

• Blood glucose

  Wear it for a total of 4 consecutive days, including the physical examination day, the control day, the exercise day, and the day following the exercise day.

• Physical activity

  Wear it for 14 days from the physical examination day

• Ambient temperature

  Wear it for 14 days from the physical examination day

• Circulating Biochemical indexes and hormones

  The venous blood of volunteers will be collected 10 times on control and exercise days. (Control day: fasting, 1,2,3,4 hours after breakfast and 2 hours after lunch. Exercise day: 0,1,2 hours after exercise and 2 hours after lunch)

• Exercise

  30 minutes after breakfast(only on the exercise day), it last for 39 minutes, 30 minutes at 100 watts and 9 minutes at 25 watts.

Study Arms (1)

Moderate to high intensity exercise

EXPERIMENTAL

BMI≥18.5, age between 18-40 years old, 81subjects.

Other: Power Bike（Ergoselect 100P）

Interventions

Power Bike（Ergoselect 100P） OTHER

Changes in the participants' energy balance will be measured through moderate to high intensity exercise. Observation of food intake, body composition, metabolic rate, food assimilation rate.

Moderate to high intensity exercise

Eligibility Criteria

• Age: 18 Years - 40 Years
• Sex: male
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Healthy adults (men)
• years old
• BMI (body mass index)≥18.5 kg/m2

You may not qualify if:

• Those who have undergone surgery in the past 6 months.
• People are requiring long-term medication.
• People have metabolic diseases, like diabetes, hypoglycemia, gout, osteoporosis, et al.
• People have digestive diseases, like gastric ulcer, pancreatitis, Intestinal obstruction, et al.
• People have sports injury, like fracture, Joint injury, et al.
• Those who have recently lost weight for various medical reasons (e.g. cancer, etc.).
• People are losing weight by tablets.
• People are suffering from infectious diseases (e.g. HIV, etc.)
• People have blood phobia, pathological hypo or hyper tension.
• People with impaired glucose tolerance.
• Those who are afflicted with claustrophobia.

Sponsors & Collaborators

• Shenzhen Institutes of Advanced Technology ,Chinese Academy of Sciences: lead

Study Sites (1)

Shenzhen Institute of Advanced Technology

Shenzhen, Guangdong, China

RECRUITING

MeSH Terms

Conditions

Motor Activity; Food Preferences

Condition Hierarchy (Ancestors)

Behavior; Feeding Behavior

Study Officials

• John Speakman

  Shenzhen Institutes of Advanced Technology ,Chinese Academy of Sciences

  STUDY CHAIR

Central Study Contacts

John R Speakman

CONTACT

+8615810868669; j.speakman@abdn.ac.uk

Li Xue

CONTACT

13538042185; xueli@siat.ac.cn

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor, Chief scientist

Study Record Dates

• First Submitted: April 2, 2024
• First Posted: May 29, 2024
• Study Start: May 20, 2024
• Primary Completion: September 30, 2025
• Study Completion: December 30, 2025
• Last Updated: August 15, 2025

Record last verified: 2025-08

Data Sharing

• IPD Sharing: Will not share

Locations

CN (1)