Impact of Brief Daily Functional Resistance Training on Lower Extremity Physical Performance

NCT06396247 | Recruiting Phase 2 DMC

• 2 other identifiers: STUDY00024492R01AG079938
• Study Type: interventional
• Target: 360
• Locations: 1 country
• Sites: 2

Brief Summary

In this study, we will randomly assign 360 older adults to 12 months of 5 minutes per day of functional resistance training or to a delayed treatment control condition, and measure the impact of the training on measures of lower extremity performance and walking ability.

Conditions

Mobility Limitation

Keywords

older adults; walking; mobility

Outcome Measures

Primary Outcomes (1)

• Short Physical Performance Battery

  The SPPB assesses balance, gait speed, and lower extremity strength.

  Baseline, 6 months, 12 months

Study Arms (2)

Functional Activity Strength TRaining

EXPERIMENTAL

Participants will perform 5 minutes of functional resistance training daily, supported by 24 video coaching sessions over 12 months.

Behavioral: Functional Activity Strength Training

Delayed Treatment

ACTIVE COMPARATOR

Participants will receive the intervention after 12 months.

Behavioral: Functional Activity Strength Training

Interventions

Functional Activity Strength Training BEHAVIORAL

FAST consists of five exercises (stepping on a step, chair stands, push-ups, rows, walking), for 30 seconds each, performed daily, with 30 seconds of rest between.

Delayed Treatment; Functional Activity Strength TRaining

Eligibility Criteria

• Age: 65 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Older Adult (65+)

You may qualify if:

• Self-reported difficulty or inability to walk ¼ mile

You may not qualify if:

• Chest pain on the PAR-Q

Sponsors & Collaborators

• Milton S. Hershey Medical Center: lead
• National Institute on Aging (NIA): collaborator

Study Sites (2)

Penn State College of Medicine

Hershey, Pennsylvania, 17033, United States

RECRUITING

University of Pittsburgh

Pittsburgh, Pennsylvania, 15261, United States

RECRUITING

MeSH Terms

Conditions

Mobility Limitation

Condition Hierarchy (Ancestors)

Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Study Officials

• Maggie Nellissery, Ph.D.

  National Institute on Aging (NIA)

  STUDY CHAIR

Central Study Contacts

Christopher Sciamanna, MD, MPH

CONTACT

610-585-9765; cns10@psu.edu

Jordan Kurth, Ph.SD.

CONTACT

815-988-6357; jkurth@pennstatehealth.psu.edu

Study Design

• Study Type: interventional
• Phase: phase 2
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: PARTICIPANT, INVESTIGATOR
• Masking Details: Randomization
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor of Medicine

Model Details: We hypothesize that patients assigned to FAST will improve these outcomes significantly more than those assigned to DTC and that FAST participants with higher levels of perceived exertion and adherence will improve these measures the most.

Study Record Dates

• First Submitted: April 29, 2024
• First Posted: May 2, 2024
• Study Start: April 9, 2025
• Primary Completion (Estimated): January 1, 2028
• Study Completion (Estimated): September 1, 2028
• Last Updated: July 16, 2025

Record last verified: 2025-07

Data Sharing

• IPD Sharing: Will share
• Shared Documents: STUDY PROTOCOL, SAP, ICF, CSR
• Time Frame: 12 months after study has completed
• Access Criteria: ICPSR Account holder

Locations

US (2)