NCT01614392

Brief Summary

This research study is looking to compare the effects of two uniquely different power training interventions (high force, lower velocity versus low force, high velocity) on changes in mobility status among older individuals at risk for mobility disability.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
52

participants targeted

Target at P25-P50 for not_applicable

Timeline
Completed

Started Sep 2009

Typical duration for not_applicable

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

Study Start

First participant enrolled

September 1, 2009

Completed
27 days until next milestone

First Submitted

Initial submission to the registry

September 28, 2009

Completed
2 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

October 1, 2011

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

October 1, 2011

Completed
8 months until next milestone

First Posted

Study publicly available on registry

June 7, 2012

Completed
6.5 years until next milestone

Results Posted

Study results publicly available

December 10, 2018

Completed
Last Updated

December 10, 2018

Status Verified

December 1, 2018

Enrollment Period

2.1 years

First QC Date

September 28, 2009

Results QC Date

May 26, 2017

Last Update Submit

December 6, 2018

Conditions

Mobility Limitation

Keywords

Resistance ExercisePhysical ActivityMobility disabilityPhysical functionMuscle StrengthOlder AdultsMobility-LimitedPeak power and strength

Outcome Measures

Primary Outcomes (1)

  • Leg Extensor Muscle Power

    Leg extensor muscle power measured on pneumatic strength testing equipment at a external force consistent with 70% of the participant maximum leg extensor strength.

    Change from baseline to Week 16

Study Arms (2)

High velocity low force Power Training

EXPERIMENTAL

Lower Extremity high velocity power training performed at lower external resistance (40% of the 1 repetition maximum muscle strength). Leg and knee extension exercises were performed twice per week (3 sets of each exercise consisting of 10 repetitions).

Behavioral: High velocity low force Power Training

Low velocity high force Power Training

EXPERIMENTAL

Lower extremity low velocity power training performed at high external resistance (70% of the 1 repetition maximum muscle strength). Leg and knee extension exercises were performed twice per week (3 sets of each exercise consisting of 10 repetitions).

Behavioral: Low velocity high force Power Training

Interventions

High velocity low force Power TrainingBEHAVIORAL

Lower Extremity high velocity power training performed at lower external resistance (40% of the 1 repetition maximum muscle strength). Leg and knee extension exercises were performed twice per week (3 sets of each exercise consisting of 10 repetitions).

High velocity low force Power Training
Low velocity high force Power TrainingBEHAVIORAL

Lower extremity low velocity power training performed at high external resistance (70% of the 1 repetition maximum muscle strength). Leg and knee extension exercises were performed twice per week (3 sets of each exercise consisting of 10 repetitions).

Low velocity high force Power Training

Eligibility Criteria

Age70 Years - 85 Years
Sexall
Healthy VolunteersYes
Age GroupsOlder Adult (65+)

You may qualify if:

  • Male and Female 70-85 yrs
  • Community dwelling
  • Short Performance Battery Score \>9
  • BMI range 19-32 kg/m2
  • Willingness to be randomized and come the laboratory for 20 weeks.

You may not qualify if:

  • Acute or Terminal Illness
  • MI in previous 6 months, symptomatic coronary artery disease or congestive heart failure.
  • Upper or Lower extremity fracture in previous 6 months
  • Uncontrolled hypertension (150/90mmHg)
  • Neuromuscular diseases and drugs that affect neuromuscular function
  • Hormone replacement therapy
  • Participation in any regular endurance or resistance training exercise during previous 3 months

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Jean Mayer USDA Human Nutrition Research Center on Aging

Boston, Massachusetts, 02111, United States

Location

MeSH Terms

Conditions

Mobility LimitationMotor Activity

Condition Hierarchy (Ancestors)

Signs and SymptomsPathological Conditions, Signs and SymptomsBehavior

Results Point of Contact

Title
Dr. Roger Fielding
Organization
Jean Mayer USDA HNRCA, Tufts University
Roger.Fielding@tufts.edu
6175563083

Study Officials

  • Roger A Fieilding, Ph D.

    Jean Mayer USDA Human Nutrition Research Center on Aging

    PRINCIPAL INVESTIGATOR

Publication Agreements

PI is Sponsor Employee
No
Restrictive Agreement
No

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
SINGLE
Who Masked
INVESTIGATOR
Purpose
TREATMENT
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Director and Senior Scientist, Professor of Nutrition, Jean Mayer USDA Human Nutrition Research Center on Aging.

Study Record Dates

First Submitted

September 28, 2009

First Posted

June 7, 2012

Study Start

September 1, 2009

Primary Completion

October 1, 2011

Study Completion

October 1, 2011

Last Updated

December 10, 2018

Results First Posted

December 10, 2018

Record last verified: 2018-12

Locations

US(1)