co Ihibtory Receptor in Preeclampsia

NCT05294952 | Not Yet Recruiting Phase 4 DMC

• 1 other identifier: zisdas
• Study Type: interventional
• Target: 82
• Locations: 0 countries
• Sites: N/A

Brief Summary

Preeclampsia is a form of hypertensive pregnancy disorder with multiorgan involvement. It is characterized by new-onset hypertension and proteinuria after 20 weeks' gestation in a woman whose blood pressure was normal before pregnancy. The condition may be serious and is a leading cause of preterm birth (before 37 weeks of pregnancy). If it is severe enough it may affect the brain function, causing seizures or coma, this is called eclampsia

Conditions

Pre-Eclampsia

Keywords

coinhibtory receptor

Outcome Measures

Primary Outcomes (1)

• early detection of preeclampsia

  detection levels of co inhibtory receptor

  1year

Study Arms (2)

preeclampsiapregnant women

EXPERIMENTAL

Inclusion criteria A total of 41 women in third trimester pregnancy complicated with PE showing: * Blood pressure ≥140/90 mmHg and * Proteinuria ≥300 mg/24 hours with or without * Edema in pregnant woman after week 20 of gestation (American Congress of Obstetricians and Gynecologists (ACOG2013) (17) B-Exclusion criteria * Patients with autoimmune, acute inflammatory, and chronic diseases, are excluded from the study.

Genetic: real time PCR

normal pregnant women

NO INTERVENTION

This will include age matched 41 normal pregnant women in their third trimester of pregnancy with normal blood pressure, absence of proteinuria, and without any other systemic or endocrine disorder.

Interventions

real time PCR GENETIC

diagnostic test

Also known as: ELISA

preeclampsiapregnant women

Eligibility Criteria

• Gender Eligibility Details: female
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)

You may qualify if:

• total of 41 women in third trimester pregnancy complicated with PE showing:
• Blood pressure ≥140/90 mmHg and
• Proteinuria ≥300 mg/24 hours with or without
• Edema in pregnant woman after week 20 of gestation (American Congress of Obstetricians and Gynecologists (ACOG2013) (17)

Sponsors & Collaborators

• Assiut University: lead

MeSH Terms

Conditions

Pre-Eclampsia

Interventions

Real-Time Polymerase Chain Reaction; Enzyme-Linked Immunosorbent Assay

Condition Hierarchy (Ancestors)

Hypertension, Pregnancy-Induced; Pregnancy Complications; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases

Intervention Hierarchy (Ancestors)

Polymerase Chain Reaction; Nucleic Acid Amplification Techniques; Genetic Techniques; Investigative Techniques; Immunoenzyme Techniques; Immunoassay; Immunologic Techniques; Immunosorbent Techniques; Immunohistochemistry; Molecular Probe Techniques

Study Design

• Study Type: interventional
• Phase: phase 4
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: PREVENTION
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: real time PCR

Model Details: preeclasmpsia pregnant women and normal pregnant women

Study Record Dates

• First Submitted: March 4, 2022
• First Posted: March 24, 2022
• Study Start: January 1, 2025
• Primary Completion: February 3, 2025
• Study Completion: November 4, 2025
• Last Updated: February 5, 2024

Record last verified: 2024-02

Data Sharing

• IPD Sharing: Will not share