Sevoflurane Versus Propofol in Endovascular Coiling of Cerebral Aneurysm

NCT06666959 | Completed DMC FDA Drug

• 2 other identifiers: TJ-IRB20230413SW-001
• Study Type: observational
• Target: 80
• Locations: 1 country
• Sites: 1

Brief Summary

The goal of this observational study is to learn about the anti-inflammatory effects of anesthetics on patients undergoing endovascular coiling of cerebral aneurysm. The main question it aims to answer is: Does sevoflurane or propofol affect the inflammatory response in subarachnoid hemorrhage? Participants already undergoing endovascular coiling of cerebral aneurysm will have their serum levels of inflammatory factors measured.

Conditions

Propofol; Sevoflurane

Outcome Measures

Primary Outcomes (1)

• Concentration of interleukin-10

  Test the concentration of interleukin-10 of the participants

  From enrollment to 3 months postoperation

Secondary Outcomes (9)

• Concentration of interleukin-1

  From enrollment to 3 months postoperation

• Concentration of interleukin-2

  From enrollment to 3 months postoperation

• Concentration of interleukin-6

  From enrollment to 3 months postoperation

• Concentration of interleukin-8

  From enrollment to 3 months postoperation

• Concentration of tumor necrosis factor

  From enrollment to 3 months postoperation

Study Arms (1)

patients undergoing endovascular coiling of cerebral aneurysm in Tongji hospital

The present clinical study was carried out with the aim of determine whether the inflammatory effect differs when using propofol or sevoflurane anesthesia.

Drug: Anesthesia Agent

Interventions

Anesthesia Agent DRUG

intravenous anesthetic and inhalation anesthetic

Also known as: sevoflurane, propofol

patients undergoing endovascular coiling of cerebral aneurysm in Tongji hospital

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

In Tongji hospital

You may qualify if:

• Consecutive patients aged 18 years and older presenting to the Tongji hospital for endovascular coiling of cerebral aneurysm were eligible for enrollment.

You may not qualify if:

• have an endocrine system disease
• pregnancy
• have other brain disorders
• take drugs that alter endocrine hormones
• receive perioperative blood derivatives

Sponsors & Collaborators

• Tongji Hospital: lead

Study Sites (1)

Department of Neurosurgery

Wuhan, Hubei, 430030, China

Location

Biospecimen

Retention: SAMPLES WITHOUT DNA

blood

MeSH Terms

Interventions

Anesthetics; Sevoflurane; Propofol

Intervention Hierarchy (Ancestors)

Central Nervous System Depressants; Physiological Effects of Drugs; Pharmacologic Actions; Chemical Actions and Uses; Central Nervous System Agents; Therapeutic Uses; Methyl Ethers; Ethers; Organic Chemicals; Hydrocarbons, Fluorinated; Hydrocarbons, Halogenated; Hydrocarbons; Phenols; Benzene Derivatives; Hydrocarbons, Aromatic; Hydrocarbons, Cyclic

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Target Duration: 3 Months
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: associate professor

Study Record Dates

• First Submitted: October 26, 2024
• First Posted: October 31, 2024
• Study Start: May 1, 2023
• Primary Completion: February 8, 2024
• Study Completion: May 8, 2024
• Last Updated: October 31, 2024

Record last verified: 2024-10

Locations

CN (1)