EQQUAL-NM for the Promotion of Smoking Cessation in Sexual and Gender Minority Young Adults in New Mexico

NCT06386432 | Withdrawn DMC

• 4 other identifiers: RG1124189NCI-2024-02453FHIRB0020404U54CA132381
• Study Type: interventional
• Target: N/A
• Locations: 1 country
• Sites: 1

Brief Summary

This clinical trial assesses the acceptability and efficacy of Empowered, Queer, Quitting, and Living--New Mexico (EQQUAL-NM), a smoking cessation intervention for sexual and gender minority young adults in New Mexico. Smoking prevalence among sexual and gender minority (SGM) adults in New Mexico is more than twice as high as non-SGM adults. Helping young adult tobacco users to quit is critical, yet there have been few efforts to develop tailored treatments specifically for this population. EQQUAL-NM is a digital smoking cessation intervention designed specifically for SGM young adult smokers in New Mexico and may help them quit smoking.

Conditions

Cigarette Smoking-Related Carcinoma

Outcome Measures

Primary Outcomes (2)

• Participant satisfaction

  Self-report of satisfaction overall and with specific program components will be rated on a 5-point Likert-type scale. Higher scale scores indicate higher satisfaction with the app.

  At 3-month follow-up

• Number of logins to the assigned application

  Server-recorded number of app openings over 3 months

  Up to 3-month follow-up

Secondary Outcomes (9)

• Self-reported 7-day point prevalence abstinence (PPA) from all nicotine and tobacco products

  At 3 months

• Biochemically confirmed 7-day point prevalence abstinence (PPA) from all nicotine/tobacco products

  At 3 months

• Self-reported 30-day PPA from all nicotine/tobacco products

  At 3 months

• Biochemically confirmed 30-day PPA from all nicotine/tobacco products

  At 3 months

• Self-reported 7-day PPA from cigarette smoking

  At 3 months

Study Arms (2)

Arm I (EQQUAL-NM, Program A)

EXPERIMENTAL

Participants receive self-guided smartphone app-delivered EQQUAL-NM (Program A) intervention on study. Participants also receive motivational messages, reminders and smoking cessation information via text messages. Some participants also complete at-home saliva sample collection during follow-up.

Behavioral: Smartphone App-delivered Smoking Cessation Intervention; Other: Health Promotion and Education; Other: Biospecimen Collection; Other: Questionnaire Administration

Arm II (EQQUAL-NM, Program B)

ACTIVE COMPARATOR

Participants receive self-guided smartphone app-delivered EQQUAL-NM (Program B) intervention on study. Participants also receive motivational messages, reminders and smoking cessation information via text messages. Some participants also complete at-home saliva sample collection during follow-up.

Behavioral: Smartphone App-delivered Smoking Cessation Intervention; Other: Health Promotion and Education; Other: Biospecimen Collection; Other: Questionnaire Administration

Interventions

Smartphone App-delivered Smoking Cessation Intervention BEHAVIORAL

Receive access to EQQUAL-NM (Program A) intervention

Also known as: Smoking and Tobacco Use Cessation Intervention

Arm I (EQQUAL-NM, Program A)

Health Promotion and Education OTHER

Receive text message reminders, motivational messages and prompts via SMS text messages (Program A)

Also known as: Text Message-Based Intervention

Arm I (EQQUAL-NM, Program A)

Biospecimen Collection OTHER

Complete at-home saliva sample collection

Also known as: Saliva Sample Collection

Arm I (EQQUAL-NM, Program A); Arm II (EQQUAL-NM, Program B)

Questionnaire Administration OTHER

Ancillary studies

Arm I (EQQUAL-NM, Program A); Arm II (EQQUAL-NM, Program B)

Eligibility Criteria

• Age: 18 Years - 30 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Self-identify being between 18 and 30 years of age
• Self-identify as a sexual and/or gender minority (i.e., a sexual orientation other than straight and/or gender that doesn't match sex assigned at birth)
• Currently reside in New Mexico, with a New Mexico mailing address, and anticipate remaining in New Mexico for the duration of the study (3 months)
• Self-report smoking at least 1 cigarette per week in the 30 days prior to screening
• Own an Android phone or iPhone
• Have at least weekly internet access for the next three months
• Willing and able to stream audio and video for this study
• Current use of a personal email account
• Current use of text messaging
• Interested in participating in the study for themselves (versus \[vs\] someone else)
• Self-report that they have not participated in one of Fred Hutch's/NMSU's prior smoking cessation studies
• Understand and agree to the conditions of compensation
• Currently not incarcerated
• Participants must be willing to use the assigned intervention program, complete the study assessments, and agree to the online consent form in English

You may not qualify if:

• Current use of other tobacco cessation treatments at the time of screening, including pharmacotherapy or behavioral support (but initiating these treatments during the study is allowed)
• Member of the same household as another research participant
• Previous use of the National Cancer Institute (NCI) QuitGuide app
• Google voice number as sole phone number
• Does not pass study fraud prevention protocol

Sponsors & Collaborators

• Fred Hutchinson Cancer Center: lead
• National Cancer Institute (NCI): collaborator
• National Cancer Institute Center to Reduce Cancer Health Disparities: collaborator
• New Mexico State University: collaborator

Study Sites (1)

Fred Hutch/University of Washington Cancer Consortium

Seattle, Washington, 98109, United States

Location

MeSH Terms

Interventions

Smoking Devices; Health Promotion; Educational Status

Intervention Hierarchy (Ancestors)

Manufactured Materials; Technology, Industry, and Agriculture; Health Education; Preventive Health Services; Health Services; Health Care Facilities Workforce and Services; Socioeconomic Factors; Population Characteristics

Study Officials

• Jaimee Heffner

  Fred Hutch/University of Washington Cancer Consortium

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: OUTCOMES ASSESSOR
• Masking Details: Any outcome evaluator who has contact with participants will remain blinded to treatment group assignment until the final set of questions regarding acceptability of specific program components is asked.
• Purpose: PREVENTION
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: April 23, 2024
• First Posted: April 26, 2024
• Study Start: December 1, 2025
• Primary Completion: April 1, 2026
• Study Completion: April 1, 2026
• Last Updated: October 8, 2025

Record last verified: 2025-04

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)