Demineralized Dentin Graft With Hydrochloric Acid Versus Nitric Acid in Alveolar Ridge Preservation
DDG
1 other identifier
interventional
8
0 countries
N/A
Brief Summary
The reduction in alveolar bone dimensions is an inevitable outcome after tooth extraction due to the healing events that results in bone modeling/remodeling. Alveolar ridge preservation is a successful approach that aids in reducing these changes greatly. Various techniques have been employed to achieve that outcome utilizing bone grafts and/or membrane. Dentin graft is a promising type that can overcome many of the limitations facing mainstream grafts. Autogenous source serve the advantage of providing graft with no cross-infection risk or immunogenicity. Moreover, the unique structure of dentin makes it suitable for osteoinduction and osteoconduction that yields favorite bone regeneration outcomes. Demineralization of dentin is essential to release trapped growth factors, expose collagen fibrils and enhance the grafts degradability and replacement by native tissues. Many acids have been investigated for the use in chairside preparation of the dentin graft and hence, clinicians are faced with different choices but little evidence regarding the acid which yield s better outcomes.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at below P25 for not_applicable
Started Oct 2020
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
May 14, 2020
CompletedFirst Posted
Study publicly available on registry
May 19, 2020
CompletedStudy Start
First participant enrolled
October 1, 2020
CompletedPrimary Completion
Last participant's last visit for primary outcome
August 31, 2021
CompletedStudy Completion
Last participant's last visit for all outcomes
October 31, 2021
CompletedJuly 15, 2020
July 1, 2020
11 months
May 14, 2020
July 13, 2020
Conditions
Outcome Measures
Primary Outcomes (1)
Radiographic bone changes
width and height losses (quantitative in mm)
6 months
Secondary Outcomes (2)
histological analysis
6 months
soft tissue healing
Biweekly for 6 weeks
Study Arms (2)
autogenous dentin graft treated with nitric acid
EXPERIMENTALautogenous dentin graft treated with hydrochloric acid
ACTIVE COMPARATORInterventions
atraumatic extraction followed by graft material insertion
Eligibility Criteria
You may qualify if:
- Non-restorable teeth
- medically healthy
- able to provide informed consent and attend follow-up period
You may not qualify if:
- pregnant
- smokers or alcoholic
- severe bone loss
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- Cairo Universitylead
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- TRIPLE
- Who Masked
- PARTICIPANT, CARE PROVIDER, OUTCOMES ASSESSOR
- Purpose
- TREATMENT
- Intervention Model
- SINGLE GROUP
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Principal investigator
Study Record Dates
First Submitted
May 14, 2020
First Posted
May 19, 2020
Study Start
October 1, 2020
Primary Completion
August 31, 2021
Study Completion
October 31, 2021
Last Updated
July 15, 2020
Record last verified: 2020-07
Data Sharing
- IPD Sharing
- Will not share