Monetary Incentive Delay Task for Probing Reward-related Neural Processes

NCT06369623 | Recruiting DMC

• 1 other identifier: IRB2023-00466
• Study Type: interventional
• Target: 300
• Locations: 1 country
• Sites: 1

Brief Summary

150 males and 150 females ages 14-17 years-old will be enrolled in an observational, longitudinal study. There are three planned in-person visits: a baseline assessment, an 18-month follow-up, and a 36-month follow-up. The in-person visits will include assessment of substance use and other individual differences (e.g., reward function, psychiatric history), neuromelanin-sensitive MRI, as well as functional brain activation collected while the participant is at rest (resting-state fMRI) and while the participant completes a Monetary Incentive Delay task. Subjects will also be asked to complete past 90-day substance use assessments remotely every 90 days for 36 months.

Conditions

Adolescent Development

Outcome Measures

Primary Outcomes (1)

• Amount of Brain Activation (BOLD Signal) during Monetary Incentive Delay Task by Condition

  fMRI activation during task during win, loss, and no change conditions, as well as anticipation and consummation phases.

  Baseline, 18-month, 36-month.

Study Arms (1)

Whole sample

EXPERIMENTAL

All enrolled subjects will complete a standard Monetary Incentive Delay Task if able. Inclusion of this task meets criteria for Basic Experimental Studies Involving Humans (BESH)

Other: Monetary Incentive Delay Task

Interventions

Monetary Incentive Delay Task OTHER

The Monetary Incentive Delay functional Magnetic Resonance Imaging task is well-characterized and commonly utilized in research settings to measure neural activation between win and loss conditions, as well as between phases of anticipation and consummation/outcome. A recent meta-analysis indicates that the task has been used in over 80 studies and 5,000 subjects as of Year 2022. The task is also valid and appropriate for use in children and adolescents, as demonstrated by its inclusion in National Institute on Drug Abuse ABCD study. The task is utilized for its short-lived, reversible, and/or benign effects on brain activation (e.g., brief processing of a reward cue).

Whole sample

Eligibility Criteria

• Age: 14 Years - 17 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17)

You may qualify if:

• Males and females ages 14-17 years-old;
• English-speaking for assent and interview completion;
• Capacity to provide assent.

You may not qualify if:

• current (within 6 months) use of medication that may affect cerebral function
• history of severe medical or neurological illness, including stroke or seizure;
• history of head trauma with loss of consciousness;
• presence of metal in the body;
• pregnancy or breastfeeding;
• recent drug or alcohol use determined by positive urine toxicology or breathalyzer (to validate self-report assessment of substance use history);
• lifetime use of psychotropic or other medication that could likely influence dopamine function, namely stimulant medication or antipsychotic medication, except a subgroup of 25 youth with history of prescribed stimulant medication and a subgroup of 15 youth with history antipsychotic medication will be enrolled for comparison purposes.

Sponsors & Collaborators

• Stony Brook University: lead

Study Sites (1)

Stony Brook Medicine

Stony Brook, New York, 11794, United States

RECRUITING

Central Study Contacts

Greg Perlman, PhD

CONTACT

1-631-638-1922; greg.perlman@stonybrookmedicine.edu

Lu-Ann Kozlowski, BSN

CONTACT

1-631-632-9036; lu-ann.kozlowski@stonybrook.edu

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: OTHER
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: April 13, 2024
• First Posted: April 17, 2024
• Study Start: April 6, 2024
• Primary Completion (Estimated): November 30, 2028
• Study Completion (Estimated): November 30, 2028
• Last Updated: May 15, 2025

Record last verified: 2025-05

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)