Jump-In: Building Better Bones

NCT00729378 | Completed Results DMC

• 1 other identifier: HD050775
• Study Type: interventional
• Target: 509
• Locations: 1 country
• Sites: 1

Brief Summary

The Jump-In study will prospectively assess the effects of impact exercise on skeletal development in young girls, including bone mass, bone mineral density, and bone geometry. We hypothesize that girls who regularly participate in impact loading exercise will accrue greater skeletal mass, increase bone density and undergo structural adaptations that in combination will improve bone strength compared to girls who do not participate in impact exercise.

Conditions

Adolescent Development

Outcome Measures

Primary Outcomes (96)

• Baseline Total Volumetric Bone Density at the Femur 4% Site

  Baseline (initial) measurement of total volumetric bone density at the femur 4% site. Measurement made by peripheral quantitative computed tomography (pQCT) at a distance of 4% of total femur length from the distal growth plate. Measurement units: milligrams per cubic centimeter (mg/ccm).

  Baseline

• Baseline Volumetric Bone Density of Trabecular Bone at the Femur 4% Site

  Baseline (initial) measurement of volumetric bone density of trabecular bone at the femur 4% site . Measurement made by pQCT at a distance of 4% of total femur length from the distal growth plate. Measurement units: milligrams per cubic centimeter (mg/ccm).

  Baseline

• Baseline Volumetric Bone Density of Cortical Bone at the Femur 4% Site

  Baseline (initial) measurement of volumetric bone density of Cortical bone at the femur 4% site . Measurement made by pQCT at a distance of 4% of total femur length from the distal growth plate. Measurement units: milligrams per cubic centimeter (mg/ccm).

  Baseline

• Baseline Trabecular Bone Area at the Femur 4% Site

  Baseline (initial) measurement of trabecular bone area at the femur 4% site . Measurement made by pQCT at a distance of 4% of total femur length from the distal growth plate. Measurement units: square millimeters (mm\^2).

  Baseline

• Baseline Cortical Bone Area at the Femur 4% Site

  Baseline (initial) measurement of cortical bone area at the femur 4% site . Measurement made by pQCT at a distance of 4% of total femur length from the distal growth plate. Measurement units: square millimeters (mm\^2).

  Baseline

• Baseline Periosteal Circumference at the Femur 4% Site

  Baseline (initial) measurement of periosteal circumference at the femur 4% site . Measurement made by pQCT at a distance of 4% of total femur length from the distal growth plate. Measurement units: millimeters (mm).

  Baseline

• Baseline Bone Strength Index at the Femur 4% Site

  Baseline (initial) measurement of bone strength index (BSI) at the femur 4% site. Bone Strength Index (BSI) is a measurement of the resistance to compression forces at the epiphyses of long bones. Measurement made by pQCT at a distance of 4% of total tibia length from the distal growth plate. Measurement units: mm\^4.

  Baseline

• Baseline Total Volumetric Bone Density at the Femur 20% Site

  Baseline (initial) measurement of total volumetric bone density at the femur 20% site . Measurement made by pQCT at a distance of 20% of total femur length from the distal growth plate. Measurement units: milligrams per cubic centimeter (mg/ccm).

  Baseline

• Baseline Volumetric Bone Density of Trabecular Bone at the Femur 20% Site

  Baseline (initial) measurement of volumetric bone density of trabecular bone at the femur 20% site . Measurement made by pQCT at a distance of 20% of total femur length from the distal growth plate. Measurement units: milligrams per cubic centimeter (mg/ccm).

  Baseline

• Baseline Volumetric Bone Density of Cortical Bone at the Femur 20% Site

  Baseline (initial) measurement of volumetric bone density of Cortical bone at the femur 20% site . Measurement made by pQCT at a distance of 20% of total femur length from the distal growth plate. Measurement units: milligrams per cubic centimeter (mg/ccm).

  Baseline

• Baseline Periosteal Circumference at the Femur 20% Site

  Baseline (initial) measurement of periosteal circumference at the femur 20% site . Measurement made by pQCT at a distance of 20% of total femur length from the distal growth plate. Measurement units: millimeters (mm).

  Baseline

• Baseline Cortical Thickness at the Femur 20% Site

  Baseline (initial) measurement of cortical thickness at the femur 20% site . Measurement made by pQCT at a distance of 20% of total femur length from the distal growth plate. Measurement units: millimeters (mm).

  Baseline

• Baseline Stress-Strain Index at the Femur 20% Site

  Baseline (initial) measurement of stress-strain index at the femur 20% site. Stress-strain index (also called strength-strain index and stress-strength index in the literature) is a measure of the resistance to torsional and bending forces at diaphyseal sites of long bones. Measurement made by pQCT at a distance of 20% of total femur length from the distal growth plate. Measurement units: mm\^3.

  Baseline

• Baseline Volumetric Bone Density of Trabecular Bone at the Tibia 4% Site

  Baseline (initial) measurement of volumetric bone density of trabecular bone at the tibia 4% site . Measurement made by pQCT at a distance of 4% of total tibia length from the distal growth plate. Measurement units: milligrams per cubic centimeter (mg/ccm).

  Baseline

• Baseline Total Volumetric Bone Density at the Tibia 4% Site

  Baseline (initial) measurement of total volumetric bone density at the tibia 4% site . Measurement made by pQCT at a distance of 4% of total tibia length from the distal growth plate. Measurement units: milligrams per cubic centimeter (mg/ccm).

  Baseline

• Baseline Volumetric Bone Density of Cortical Bone at the Tibia 4% Site

  Baseline (initial) measurement of volumetric bone density of cortical bone at the tibia 4% site . Measurement made by pQCT at a distance of 4% of total tibia length from the distal growth plate. Measurement units: milligrams per cubic centimeter (mg/ccm).

  Baseline

• Baseline Trabecular Bone Area at the Tibia 4% Site

  Baseline (initial) measurement of trabecular bone area at the tibia 4% site . Measurement made by pQCT at a distance of 4% of total tibia length from the distal growth plate. Measurement units: square millimeters (mm\^2).

  Baseline

• Baseline Cortical Bone Area at the Tibia 4% Site

  Baseline (initial) measurement of cortical bone area at the tibia 4% site . Measurement made by pQCT at a distance of 4% of total tibia length from the distal growth plate. Measurement units: square millimeters (mm\^2).

  Baseline

• Baseline Periosteal Circumference at the Tibia 4% Site

  Baseline (initial) measurement of periosteal circumference at the tibia 4% site . Measurement made by pQCT at a distance of 4% of total tibia length from the distal growth plate. Measurement units: millimeters (mm).

  Baseline

• Baseline Bone Strength Index at the Tibia 4% Site

  Baseline (initial) measurement of bone strength index (BSI) at the tibia 4% site. Bone Strength Index (BSI) is a measurement of the resistance to compression forces at the epiphyses of long bones. Measurement made by pQCT at a distance of 4% of total tibia length from the distal growth plate. Measurement units: mm\^4.

  Baseline

• Baseline Total Volumetric Bone Density at the Tibia 50% Site

  Baseline (initial) measurement of total volumetric bone density at the tibia 50% site . Measurement made by pQCT at a distance of 50% of total tibia length from the distal growth plate. Measurement units: milligrams per cubic centimeter (mg/ccm).

  Baseline

• Baseline Volumetric Bone Density of Trabecular Bone at the Tibia 50% Site

  Baseline (initial) measurement of volumetric bone density of trabecular bone at the tibia 50% site . Measurement made by pQCT at a distance of 50% of total tibia length from the distal growth plate. Measurement units: milligrams per cubic centimeter (mg/ccm).

  Baseline

• Baseline Volumetric Bone Density of Cortical Bone at the Tibia 50% Site

  Baseline (initial) measurement of volumetric bone density of cortical bone at the tibia 50% site . Measurement made by pQCT at a distance of 50% of total tibia length from the distal growth plate. Measurement units: milligrams per cubic centimeter (mg/ccm).

  Baseline

• Baseline Periosteal Circumference at the Tibia 50% Site

  Baseline (initial) measurement of periosteal circumference at the tibia 50% site . Measurement made by pQCT at a distance of 50% of total tibia length from the distal growth plate. Measurement units: millimeters (mm).

  Baseline

• Baseline Cortical Thickness at the Tibia 50% Site

  Baseline (initial) measurement of cortical thickness at the tibia 50% site . Measurement made by pQCT at a distance of 50% of total tibia length from the distal growth plate. Measurement units: millimeters (mm).

  Baseline

• Baseline Stress-Strain Index at the Tibia 50% Site

  Baseline (initial) measurement of stress-strain index at the tibia 50% site. Stress-strain index (also called strength-strain index and stress-strength index in the literature) is a measure of the resistance to torsional and bending forces at diaphyseal sites of long bones. Measurement made by pQCT at a distance of 50% of total tibia length from the distal growth plate. Measurement units: mm\^3.

  Baseline

• Baseline Total Volumetric Bone Density at the Tibia 66% Site

  Baseline (initial) measurement of total volumetric bone density at the tibia 66% site . Measurement made by pQCT at a distance of 66% of total tibia length from the distal growth plate. Measurement units: milligrams per cubic centimeter (mg/ccm).

  Baseline

• Baseline Volumetric Bone Density of Trabecular Bone at the Tibia 66% Site

  Baseline (initial) measurement of volumetric bone density of trabecular bone at the tibia 66% site . Measurement made by pQCT at a distance of 66% of total tibia length from the distal growth plate. Measurement units: milligrams per cubic centimeter (mg/ccm).

  Baseline

• Baseline Volumetric Bone Density of Cortical Bone at the Tibia 66% Site

  Baseline (initial) measurement of volumetric bone density of cortical bone at the tibia 66% site . Measurement made by pQCT at a distance of 66% of total tibia length from the distal growth plate. Measurement units: milligrams per cubic centimeter (mg/ccm).

  Baseline

• Baseline Periosteal Circumference at the Tibia 66% Site

  Baseline (initial) measurement of periosteal circumference at the tibia 66% site . Measurement made by pQCT at a distance of 66% of total tibia length from the distal growth plate. Measurement units: millimeters (mm).

  Baseline

• Baseline Cortical Thickness at the Tibia 66% Site

  Baseline (initial) measurement of cortical thickness at the tibia 66% site . Measurement made by pQCT at a distance of 66% of total tibia length from the distal growth plate. Measurement units: millimeters (mm).

  Baseline

• Baseline Stress-Strain Index at the Tibia 66% Site

  Baseline (initial) measurement of strength-strain index at the tibia 66% site. Stress-strain index (also called strength-strain index and stress-strength index in the literature) is a measure of the resistance to torsional and bending forces at diaphyseal sites of long bones. Measurement made by pQCT at a distance of 66% of total tibia length from the distal growth plate. Measurement units: mm\^3.

  Baseline

• 12-month Change in Total Volumetric Bone Density the Femur 4% Site

  Baseline to 12-month change in total volumetric bone density at the femur 4% site . Measurement made by pQCT at a distance of 4% of total femur length from the distal growth plate. Measurement units: milligrams per cubic centimeter (mg/ccm).

  Baseline to 12-months

• 12-month Change in Volumetric Bone Density of Trabecular Bone at the Femur 4% Site

  Baseline to 12-month change in volumetric bone density of trabecular bone at the femur 4% site . Measurement made by pQCT at a distance of 4% of total femur length from the distal growth plate. Measurement units: milligrams per cubic centimeter (mg/ccm).

  Baseline to 12-months

• 12-month Change in Volumetric Bone Density of Cortical Bone at the Femur 4% Site

  Baseline to 12-month change in volumetric bone density of cortical bone at the femur 4% site . Measurement made by pQCT at a distance of 4% of total femur length from the distal growth plate. Measurement units: milligrams per cubic centimeter (mg/ccm).

  Baseline to 12-months

• 12-month Change in Trabecular Bone Area at the Femur 4% Site

  Baseline to 12-month change in trabecular bone area at the femur 4% site . Measurement made by pQCT at a distance of 4% of total femur length from the distal growth plate. Measurement units: square millimeters (mm\^2).

  Baseline to 12-months

• 12-month Change in Cortical Bone Area at the Femur 4% Site

  Baseline to 12-month change in cortical bone area at the femur 4% site . Measurement made by pQCT at a distance of 4% of total femur length from the distal growth plate. Measurement units: square millimeters (mm\^2).

  Baseline to 12-months

• 12-month Change in Periosteal Circumference at the Femur 4% Site

  Baseline to 12-month change in periosteal circumference at the femur 4% site . Measurement made by pQCT at a distance of 4% of total femur length from the distal growth plate. Measurement units: millimeters (mm).

  Baseline to 12-months

• 12-month Change in Bone Strength Index at the Femur 4% Site

  Baseline to 12-month change in bone strength index (BSI) at the femur 4% site. Bone Strength Index (BSI) is a measurement of the resistance to compression forces at the epiphyses of long bones. Measurement made by pQCT at a distance of 4% of total tibia length from the distal growth plate. Measurement units: mm\^4.

  Baseline to 12-months

• 12-month Change in Total Volumetric Bone Density at the Femur 20% Site

  Baseline to 12-month change in total volumetric bone density at the femur 20% site . Measurement made by pQCT at a distance of 20% of total femur length from the distal growth plate. Measurement units: milligrams per cubic centimeter (mg/ccm).

  Baseline to 12-months

• 12-month Change in Volumetric Bone Density of Trabecular Bone at the Femur 20% Site

  Baseline to 12-month change in volumetric bone density of trabecular bone at the femur 20% site . Measurement made by pQCT at a distance of 20% of total femur length from the distal growth plate. Measurement units: milligrams per cubic centimeter (mg/ccm).

  Baseline to 12-months

• 12-month Change in Volumetric Bone Density of Cortical Bone at the Femur 20% Site

  Baseline to 12-month change in volumetric bone density of cortical bone at the femur 20% site . Measurement made by pQCT at a distance of 20% of total femur length from the distal growth plate. Measurement units: milligrams per cubic centimeter (mg/ccm).

  Baseline to 12-months

• 12-month Change in Thickness of Cortical Bone at the Femur 20% Site

  Baseline to 12-month change in thickness of cortical bone at the femur 20% site . Measurement made by pQCT at a distance of 20% of total femur length from the distal growth plate. Measurement units millimeters (mm).

  Baseline to 12-months

• 12-month Change in Periosteal Circumference at the Femur 20% Site

  Baseline to 12-month change in periosteal circumference at the femur 20% site . Measurement made by pQCT at a distance of 20% of total femur length from the distal growth plate. Measurement units: millimeters (mm).

  Baseline to 12-months

• 12-month Change in Stress-Strain Index at the Femur 20% Site

  Baseline to 12-month change in strength-strain index at the femur 20% site. Stress-strain index (also called strength-strain index and stress-strength index in the literature) is a measure of the resistance to torsional and bending forces at diaphyseal sites of long bones. Measurement made by pQCT at a distance of 20% of total femur length from the distal growth plate. Measurement units: mm\^3.

  Baseline to 12-months

• 12-month Change in Total Volumetric Bone Density at the Tibia 4% Site

  Baseline to 12-month change in total volumetric bone density at the tibia 4% site . Measurement made by pQCT at a distance of 4% of total tibia length from the distal growth plate. Measurement units: milligrams per cubic centimeter (mg/ccm).

  Baseline to 12-months

• 12-month Change in Volumetric Bone Density of Trabecular Bone at the Tibia 4% Site

  Baseline to 12-month change in volumetric bone density of trabecular bone at the tibia 4% site . Measurement made by pQCT at a distance of 4% of total tibia length from the distal growth plate. Measurement units: milligrams per cubic centimeter (mg/ccm).

  Baseline to 12-months

• 12-month Change in Volumetric Bone Density of Cortical Bone at the Tibia 4% Site

  Baseline to 12-month change in volumetric bone density of cortical bone at the tibia 4% site . Measurement made by pQCT at a distance of 4% of total tibia length from the distal growth plate. Measurement units: milligrams per cubic centimeter (mg/ccm).

  Baseline to 12-months

• 12-month Change in Trabecular Bone Area at the Tibia 4% Site

  Baseline to 12-month change in trabecular bone area at the tibia 4% site . Measurement made by pQCT at a distance of 4% of total tibia length from the distal growth plate. Measurement units: square millimeters (mm\^2).

  Baseline to 12-months

• 12-month Change in Cortical Bone Area at the Tibia 4% Site

  Baseline to 12-month change in cortical bone area at the tibia 4% site . Measurement made by pQCT at a distance of 4% of total tibia length from the distal growth plate. Measurement units: square millimeters (mm\^2).

  Baseline to 12-months

• 12-month Change in Periosteal Circumference at the Tibia 4% Site

  Baseline to 12-month change in periosteal circumference at the tibia 4% site . Measurement made by pQCT at a distance of 4% of total tibia length from the distal growth plate. Measurement units: millimeters (mm).

  Baseline to 12-months

• 12-month Change in Bone Strength Index at the Tibia 4% Site

  Baseline to 12-month change in bone strength index (BSI) at the tibia 4% site. Bone Strength Index (BSI) is a measurement of the resistance to compression forces at the epiphyses of long bones. Measurement made by pQCT at a distance of 4% of total tibia length from the distal growth plate. Measurement units: mm\^4.

  Baseline to 12-months

• 12-month Change in Total Volumetric Bone Density at the Tibia 50% Site

  Baseline to 12-month change in total volumetric bone density at the tibia 50% site . Measurement made by pQCT at a distance of 50% of total tibia length from the distal growth plate. Measurement units: milligrams per cubic centimeter (mg/ccm).

  Baseline to 12-months

• 12-month Change in Volumetric Bone Density of Trabecular Bone at the Tibia 50% Site

  Baseline to 12-month change in volumetric bone density of trabecular bone at the tibia 50% site . Measurement made by pQCT at a distance of 50% of total tibia length from the distal growth plate. Measurement units: milligrams per cubic centimeter (mg/ccm).

  Baseline to 12-months

• 12-month Change in Volumetric Bone Density of Cortical Bone at the Tibia 50% Site

  Baseline to 12-month change in volumetric bone density of cortical bone at the tibia 50% site . Measurement made by pQCT at a distance of 50% of total tibia length from the distal growth plate. Measurement units: milligrams per cubic centimeter (mg/ccm).

  Baseline to 12-months

• 12-month Change in Periosteal Circumference at the Tibia 50% Site

  Baseline to 12-month change in periosteal circumference at the tibia 50% site . Measurement made by pQCT at a distance of 50% of total tibia length from the distal growth plate. Measurement units: millimeters (mm).

  Baseline to 12-months

• 12-month Change in Cortical Thickness at the Tibia 50% Site

  Baseline to 12-month change in cortical thickness at the tibia 50% site . Measurement made by pQCT at a distance of 50% of total tibia length from the distal growth plate. Measurement units: millimeters (mm).

  Baseline to 12-months

• 12-month Change in Stress-Strain Index at the Tibia 50% Site

  Baseline to 12-month change in strength-strain index at the tibia 50% site. Stress-strain index (also called strength-strain index and stress-strength index in the literature) is a measure of the resistance to torsional and bending forces at diaphyseal sites of long bones. Measurement made by pQCT at a distance of 50% of total tibia length from the distal growth plate. Measurement units: mm\^3.

  Baseline to 12-months

• 12-month Change in Total Volumetric Bone Density at the Tibia 66% Site

  Baseline to 12-month change in total volumetric bone density at the tibia 66% site . Measurement made by pQCT at a distance of 66% of total tibia length from the distal growth plate. Measurement units: milligrams per cubic centimeter (mg/ccm).

  Baseline to 12-months

• 12-month Change in Volumetric Bone Density of Trabecular Bone at the Tibia 66% Site

  Baseline to 12-month change in volumetric bone density of trabecular bone at the tibia 66% site . Measurement made by pQCT at a distance of 66% of total tibia length from the distal growth plate.Measurement units: milligrams per cubic centimeter (mg/ccm).

  Baseline to 12-months

• 12-month Change in Volumetric Bone Density of Cortical Bone at the Tibia 66% Site

  Baseline to 12-month change in volumetric bone density of cortical bone at the tibia 66% site . Measurement made by pQCT at a distance of 66% of total tibia length from the distal growth plate. Measurement units: milligrams per cubic centimeter (mg/ccm).

  Baseline to 12-months

• 12-month Change in Periosteal Circumference at the Tibia 66% Site

  Baseline to 12-month change in periosteal circumference at the tibia 66% site . Measurement made by pQCT at a distance of 66% of total tibia length from the distal growth plate. Measurement units: millimeters (mm).

  Baseline to 12-months

• 12-month Change in Cortical Thickness at the Tibia 66% Site

  Baseline to 12-month change in cortical thickness at the tibia 66% site . Measurement made by pQCT at a distance of 66% of total tibia length from the distal growth plate. Measurement units: millimeters (mm).

  Baseline to 12-months

• 12-month Change in Stress-Strain Index at the Tibia 66% Site

  Baseline to 12-month change in strength-strain index at the tibia 66% site. Stress-strain index (also called strength-strain index and stress-strength index in the literature) is a measure of the resistance to torsional and bending forces at diaphyseal sites of long bones. Measurement made by pQCT at a distance of 66% of total tibia length from the distal growth plate. Measurement units: mm\^3.

  Baseline to 12-months

• 24-month in Change in Total Volumetric Bone Density the Femur 4% Site

  Baseline to 24-month change in total volumetric bone density at the femur 4% site . Measurement made by pQCT at a distance of 4% of total femur length from the distal growth plate. Measurement units mg/ccm.

  Baseline to 24-months

• 24-month in Change in Volumetric Bone Density of Trabecular Bone at the Femur 4% Site

  Baseline to 24-month change in volumetric bone density of trabecular bone at the femur 4% site . Measurement made by pQCT at a distance of 4% of total femur length from the distal growth plate. Measurement units: milligrams per cubic centimeter (mg/ccm).

  Baseline to 24-months

• 24-month in Change in Volumetric Bone Density of Cortical Bone at the Femur 4% Site

  Baseline to 24-month change in volumetric bone density of cortical bone at the femur 4% site . Measurement made by pQCT at a distance of 4% of total femur length from the distal growth plate. Measurement units: milligrams per cubic centimeter (mg/ccm).

  Baseline to 24-months

• 24-month Change in Trabecular Bone Area at the Femur 4% Site

  Baseline to 24-month change in trabecular bone area at the femur 4% site . Measurement made by pQCT at a distance of 4% of total femur length from the distal growth plate. Measurement units: square millimeters (mm\^2).

  Baseline to 24-months

• 24-month Change in Cortical Bone Area at the Femur 4% Site

  Baseline to 24-month change in cortical bone area at the femur 4% site . Measurement made by pQCT at a distance of 4% of total femur length from the distal growth plate. Measurement units: square millimeters (mm\^2).

  Baseline to 24-months

• 24-month Change in Periosteal Circumference at the Femur 4% Site

  Baseline to 24-month change in periosteal circumference at the femur 4% site . Measurement made by pQCT at a distance of 4% of total femur length from the distal growth plate. Measurement units: millimeters (mm).

  Baseline to 24-months

• 24-month Change in Bone Strength Index at the Femur 4% Site

  Baseline to 24-month change in bone strength index (BSI) at the femur 4% site. Bone Strength Index (BSI) is a measurement of the resistance to compression forces at the epiphyses of long bones. Measurement made by pQCT at a distance of 4% of total tibia length from the distal growth plate. Measurement units: mm\^4.

  Baseline to 24-months

• 24-month Change in Total Volumetric Bone Density at the Femur 20% Site

  Baseline to 24-month change in total volumetric bone density at the femur 20% site . Measurement made by pQCT at a distance of 20% of total femur length from the distal growth plate. Measurement units: milligrams per cubic centimeter (mg/ccm).

  Baseline to 24-months

• 24-month Change in Volumetric Bone Density of Trabecular Bone at the Femur 20% Site

  Baseline to 24-month change in volumetric bone density of trabecular bone at the femur 20% site . Measurement made by pQCT at a distance of 20% of total femur length from the distal growth plate. Measurement units: milligrams per cubic centimeter (mg/ccm).

  Baseline to 24-months

• 24-month Change in Volumetric Bone Density of Cortical Bone at the Femur 20% Site

  Baseline to 24-month change in volumetric bone density of cortical bone at the femur 20% site . Measurement made by pQCT at a distance of 20% of total femur length from the distal growth plate. Measurement units: milligrams per cubic centimeter (mg/ccm).

  Baseline to 24-months

• 24-month Change in Thickness of Cortical Bone at the Femur 20% Site

  Baseline to 24-month change in thickness of cortical bone at the femur 20% site . Measurement made by pQCT at a distance of 20% of total femur length from the distal growth plate. Measurement units: millimeters (mm).

  Baseline to 24-months

• 24-month Change in Periosteal Circumference at the Femur 20% Site

  Baseline to 24-month change in periosteal circumference at the femur 20% site . Measurement made by pQCT at a distance of 20% of total femur length from the distal growth plate. Measurement units: millimeters (mm).

  Baseline to 24-months

• 24-month Change in Stress-Strain Index at the Femur 20% Site

  Baseline to 24-month change in strength-strain index at the femur 20% site. Stress-strain index (also called strength-strain index and stress-strength index in the literature) is a measure of the resistance to torsional and bending forces at diaphyseal sites of long bones. Measurement made by pQCT at a distance of 20% of total femur length from the distal growth plate. Measurement units: mm\^3.

  Baseline to 24-months

• 24-month Change in Total Volumetric Bone Density at the Tibia 4% Site

  Baseline to 24-month change in total volumetric bone density at the tibia 4% site . Measurement made by pQCT at a distance of 4% of total tibia length from the distal growth plate. Measurement units: milligrams per cubic centimeter (mg/ccm).

  Baseline to 24-months

• 24-month Change in Volumetric Bone Density of Trabecular Bone at the Tibia 4% Site

  Baseline to 24-month change in volumetric bone density of trabecular bone at the tibia 4% site . Measurement made by pQCT at a distance of 4% of total tibia length from the distal growth plate. Measurement units: milligrams per cubic centimeter (mg/ccm).

  Baseline to 24-months

• 24-month Change in Volumetric Bone Density of Cortical Bone at the Tibia 4% Site

  Baseline to 24-month change in volumetric bone density of cortical bone at the tibia 4% site . Measurement made by pQCT at a distance of 4% of total tibia length from the distal growth plate. Measurement units: milligrams per cubic centimeter (mg/ccm).

  Baseline to 24-months

• 24-month Change in Trabecular Bone Area at the Tibia 4% Site

  Baseline to 24-month change in trabecular bone area at the tibia 4% site . Measurement made by pQCT at a distance of 4% of total tibia length from the distal growth plate. Measurement units: square millimeters (mm\^2).

  Baseline to 24-months

• 24-month Change in Cortical Bone Area at the Tibia 4% Site

  Baseline to 24-month change in cortical bone area at the tibia 4% site . Measurement made by pQCT at a distance of 4% of total tibia length from the distal growth plate. Measurement units: square millimeters (mm\^2).

  Baseline to 24-months

• 24-month Change in Periosteal Circumference at the Tibia 4% Site

  Baseline to 24-month change in periosteal circumference at the tibia 4% site . Measurement made by pQCT at a distance of 4% of total tibia length from the distal growth plate. Measurement units: millimeters (mm).

  Baseline to 24-months

• 24-month Change in Bone Strength Index at the Tibia 4% Site

  Baseline to 24-month change in bone strength index (BSI) at the tibia 4% site. Bone Strength Index (BSI) is a measurement of the resistance to compression forces at the epiphyses of long bones. Measurement made by pQCT at a distance of 4% of total tibia length from the distal growth plate. Measurement units: mm\^4.

  Baseline to 24-months

• 24-month Change in Total Volumetric Bone Density at the Tibia 50% Site

  Baseline to 24-month change in total volumetric bone density at the tibia 50% site . Measurement made by pQCT at a distance of 50% of total tibia length from the distal growth plate. Measurement units: milligrams per cubic centimeter (mg/ccm).

  Baseline to 24-months

• 24-month Change in Volumetric Bone Density of Trabecular Bone at the Tibia 50% Site

  Baseline to 24-month change in volumetric bone density of trabecular bone at the tibia 50% site . Measurement made by pQCT at a distance of 50% of total tibia length from the distal growth plate. Measurement units: milligrams per cubic centimeter (mg/ccm).

  Baseline to 24-months

• 24-month Change in Volumetric Bone Density of Cortical Bone at the Tibia 50% Site

  Baseline to 24-month change in volumetric bone density of cortical bone at the tibia 50% site . Measurement made by pQCT at a distance of 50% of total tibia length from the distal growth plate. Measurement units: milligrams per cubic centimeter (mg/ccm).

  Baseline to 24-months

• 24-month Change in Periosteal Circumference at the Tibia 50% Site

  Baseline to 24-month measurement of periosteal circumference at the tibia 50% site . Measurement made by pQCT at a distance of 50% of total tibia length from the distal growth plate. Measurement units: millimeters (mm).

  Baseline to 24-months

• 24-month Change in Cortical Thickness at the Tibia 50% Site

  Baseline to 24-month change in cortical thickness at the tibia 50% site . Measurement made by pQCT at a distance of 50% of total tibia length from the distal growth plate. Measurement units: millimeters (mm).

  Baseline to 24-months

• 24-month Change in Stress-Strain Index at the Tibia 50% Site

  Baseline to 24-month change in strength-strain index at the tibia 50% site. Stress-strain index (also called strength-strain index and stress-strength index in the literature) is a measure of the resistance to torsional and bending forces at diaphyseal sites of long bones. Measurement made by pQCT at a distance of 50% of total tibia length from the distal growth plate. Measurement units: mm\^3.

  Baseline to 24-months

• 24-month Change in Total Volumetric Bone Density at the Tibia 66% Site

  Baseline to 24-month change in total volumetric bone density at the tibia 66% site . Measurement made by pQCT at a distance of 66% of total tibia length from the distal growth plate. Measurement units: milligrams per cubic centimeter (mg/ccm).

  Baseline to 24-months

• 24-month Change in Volumetric Bone Density of Trabecular Bone at the Tibia 66% Site

  Baseline to 24-month change in volumetric bone density of trabecular bone at the tibia 66% site . Measurement made by pQCT at a distance of 66% of total tibia length from the distal growth plate. Measurement units: milligrams per cubic centimeter (mg/ccm).

  Baseline to 24-months

• 24-month Change in Volumetric Bone Density of Cortical Bone at the Tibia 66% Site

  Baseline to 24-month change in volumetric bone density of cortical bone at the tibia 66% site . Measurement made by pQCT at a distance of 66% of total tibia length from the distal growth plate. Measurement units: milligrams per cubic centimeter (mg/ccm).

  Baseline to 24-months

• 24-month Change in Periosteal Circumference at the Tibia 66% Site

  Baseline to 24-month change in periosteal circumference at the tibia 66% site . Measurement made by pQCT at a distance of 66% of total tibia length from the distal growth plate. Measurement units: millimeters (mm).

  Baseline to 24-months

• 24-month Change in Cortical Thickness at the Tibia 66% Site

  Baseline to 24-month change in cortical thickness at the tibia 66% site . Measurement made by pQCT at a distance of 66% of total tibia length from the distal growth plate. Measurement units: millimeters (mm).

  Baseline to 24-months

• 24-month Change in Stress-Strain Index at the Tibia 66% Site

  Baseline to 24-month change in strength-strain index at the tibia 66% site. Stress-strain index (also called strength-strain index and stress-strength index in the literature) is a measure of the resistance to torsional and bending forces at diaphyseal sites of long bones. Measurement made by pQCT at a distance of 66% of total tibia length from the distal growth plate. Measurement units: mm\^3.

  Baseline to 24-months

Study Arms (2)

Exercise Intervention

EXPERIMENTAL

Implementation of intervention program designed to provide skeletal loading through high impact activities. All activities performed by subjects in exercise intervention arm will be assessed by physical activity questionnaire and use of pedometer. Have baseline anthropometric measurements, total body DXA scans and peripheral quantitative computed tomography (pQCT) scans of the tibia and femur.

Other: Skeletal loading

Control

NO INTERVENTION

Participants in this arm will not take part in exercise intervention. All activities performed by subjects in control arm will be assessed by physical activity questionnaire and use of pedometer. Have baseline anthropometric measurements, total body DXA scans and peripheral quantitative computed tomography (pQCT) scans of the tibia and femur.

Interventions

Skeletal loading OTHER

Impact activities, 3 times per week, increasing the number of jumps (up to 40) and increasing height (from 6 inches to 24 inches per repetition) over the initial 8-weeks (2 months). New activities will be introduced approximately every 2-3 months in order to continually stress the skeleton over 2 years.

Exercise Intervention

Eligibility Criteria

• Age: 9 Years - 12 Years
• Sex: female
• Healthy Volunteers: Yes
• Age Groups: Child (0-17)

You may qualify if:

• female; entering 4th or 6th grade at enrollment; and willing and able to undergo all of the testing requirements; no physical conditions that limit participation in physical activity/exercise; able to read and write English.

You may not qualify if:

• Girls with severe learning disabilities (identified by schools), who are unable to complete questionnaires or otherwise comply with assessment protocols will be excluded. Any subjects (or potential subjects) suffering from medical conditions and/or disabilities that would limit their participation in exercise will be excluded from the study, following the American Academy of Pediatrics (AAP) guidelines. Further, any volunteers who are taking medications that would limit exercise and/or alter bone mineral accrual will also be excluded from the study. Girls with a positive pregnancy screening test at the time of the lab visit before DXA scanning will be excluded.

Sponsors & Collaborators

• University of Arizona: lead

Study Sites (1)

University of Arizona-Ina Gittings Bldg. #93

Tucson, Arizona, 85721, United States

Location

Related Publications (2)

• Farr JN, Van Loan MD, Lohman TG, Going SB. Lower physical activity is associated with skeletal muscle fat content in girls. Med Sci Sports Exerc. 2012 Jul;44(7):1375-81. doi: 10.1249/MSS.0b013e31824749b2.

  PMID: 22217562 DERIVED

• Farr JN, Tomas R, Chen Z, Lisse JR, Lohman TG, Going SB. Lower trabecular volumetric BMD at metaphyseal regions of weight-bearing bones is associated with prior fracture in young girls. J Bone Miner Res. 2011 Feb;26(2):380-7. doi: 10.1002/jbmr.218.

  PMID: 20721933 DERIVED

Results Point of Contact

• Title: Dr. Scott Going, Ph.D.
• Organization: University of Arizona

going@u.arizona.edu

520-626-3432

Study Officials

• Scott Going, Ph.D.

  University of Arizona-Dept. of Nutritional Sciences

  PRINCIPAL INVESTIGATOR

Publication Agreements

• PI is Sponsor Employee: Yes

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Department Head

Study Record Dates

• First Submitted: August 5, 2008
• First Posted: August 7, 2008
• Study Start: April 1, 2007
• Primary Completion: April 1, 2012
• Study Completion: April 1, 2013
• Last Updated: October 28, 2025
• Results First Posted: December 8, 2017

Record last verified: 2021-03

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)