Acute Effects of Dietary Medium-chain Fatty Acids on Lipid Profile

NCT06368271 | Completed

• 1 other identifier: Lipidomix
• Study Type: interventional
• Target: 4
• Locations: 1 country
• Sites: 2

Brief Summary

In the present study the plasma lipid profile was elucidated in healthy, lean males by the use of lipidomic analysis in the hours after an acute intake of medium-chain fatty acids (MCT) and long chain fatty acids (LCT),, respectively. In addition oxygen uptake was measured to study energy turnover.

Conditions

Healthy Nutrition; Diet, Healthy

Keywords

medium-chain fatty acids; lipidomics; acute intervention

Outcome Measures

Primary Outcomes (1)

• Meal test including medium-chain fatty acids

  In this study the effect of an acute intake of MCT oil compared with the intake of LCT (containing 35g of MCT or LCT oil diluted in 100g of low-fat, low-carb cocoa milk ) on the plasma lipid profile is studied in healthy men. Blood is obtained postprandially ( frequently during 4 hours) and analyzed for the plasma lipid profile

  0-4 hours

Secondary Outcomes (1)

• Resting metabolic rate

  0-4 hours

Study Arms (1)

Intake of fatty acids

EXPERIMENTAL

,Participants ingest a test drink containing 35g of MCT or LCT oil diluted in 100g of low-fat, low-carb cocoa milk) within five min. Blood and oxygen uptake are obtained frequently during the following 4 hours.

Dietary Supplement: Lipidomics

Interventions

Lipidomics DIETARY_SUPPLEMENT

Health beneficial effects of medium-chain fatty acids

Intake of fatty acids

Eligibility Criteria

• Age: 20 Years - 30 Years
• Sex: male
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• healthy males BMI:20-27 recreationally physical active non-smoker no medicine

You may not qualify if:

• high habitual intake of MCT-rich foods as coconut, coconut oil and dairy products

Sponsors & Collaborators

• University of Copenhagen: lead

Study Sites (2)

University of Copenhagen

Copenhagen, 2100, Denmark

Location

Department of Nutrition, Exercise and Sports

Copenhagen, Denmark

Location

Study Officials

• Bente Kiens, D.sci, PhD

  University of Copenhagen

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor

Model Details: This study is a randomized, double-blinded crossover design. Participants ingest Medium-chain-fatty acids (MCT) or Long-chain fatty acids (LCT) oil on two test days with one-week period between the experimental days. The day prior to the experimental days, the participants consume a eucaloric control diet, and abstain from alcohol and vigorous physical activity to ensure similar conditions on experimental days.

Study Record Dates

• First Submitted: April 5, 2024
• First Posted: April 16, 2024
• Study Start: October 1, 2021
• Primary Completion: February 28, 2024
• Study Completion: February 28, 2024
• Last Updated: April 16, 2024

Record last verified: 2024-04

Locations

DK (2)