Medium Chain Fatty Acids and Ketones

NCT06289296 | Completed

• 1 other identifier: MCT
• Study Type: interventional
• Target: 16
• Locations: 1 country
• Sites: 1

Brief Summary

16 participants were randomized to complete two seven-day intervention periods with twice-daily consumption of Medium-chain fatty acids (MCT) or long-chain fatty acids (LCT) oil. Before and after each intervention, participants completed a five-hour experimental day evaluating the response to a first intake of the MCT or LCT oils (pre MCT or LCT), which was repeated after the intervention period of daily intake (post MCT or LCT) (Fig. The intervention periods were separated by a 2-4-week washout period.

Conditions

Diet, Healthy; Health

Keywords

medium-chain fatty acids; ketones; Obesity

Outcome Measures

Primary Outcomes (1)

• Ketone bodies in plasma

  an increase in plasma ketone bodies induced by intake of medium-chain fatty acids in lean and obese participants

  Day 0 to day 7

Study Arms (2)

Fatty acid intake in lean males

EXPERIMENTAL

Lean males will be studied before and after 7 days daily intake of either Medium-chain fatty acids or Long-chain fatty acids. . After a wash-out period the intervention is repeated in opposite sequence.

Other: Fatty acid intake in lean and obese males

Fatty acid intake in obese males

EXPERIMENTAL

In obese male participants will be studied before and after 7 days daily intake of either medium-chain fatty acids (MCT) or long-chain fatty acids (LCT). After a wash-out period the intervention is repeated in opposite sequence.

Other: Fatty acid intake in lean and obese males

Interventions

Fatty acid intake in lean and obese males OTHER

Acute and chronic intake of MCT and LCT

Fatty acid intake in lean males; Fatty acid intake in obese males

Eligibility Criteria

• Age: 20 Years - 45 Years
• Sex: male
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• BMI between 20 and 35
• Moderate physical activity level, defined as 1 to 3 weekly sessions of exercise.
• Non-smokers
• No use of medicine
• No known prediabetes or diabetes

You may not qualify if:

• High habitual intake of MCFA (e.g., coconut milk, coconut oil, or dairy products), A ketogenic diet, known diabetes or pre-diabetes, use of medications, daily use of nicotine products

Sponsors & Collaborators

• University of Copenhagen: lead

Study Sites (1)

University of Copenhagen

Copenhagen, 2100, Denmark

Location

MeSH Terms

Conditions

Ketosis; Obesity

Condition Hierarchy (Ancestors)

Acidosis; Acid-Base Imbalance; Metabolic Diseases; Nutritional and Metabolic Diseases; Overweight; Overnutrition; Nutrition Disorders; Body Weight; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Study Officials

• Bente Kiens, D.sci, PhD

  University of Copenhagen

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NON RANDOMIZED
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor

Model Details: A parallel crossover design, in which a group of lean and a group of obese participants are allocated to complete two seven-day intervention periods with twice daily consumption of either medium-chain fatty acids or long-chain fatty acids.

Study Record Dates

• First Submitted: February 25, 2024
• First Posted: March 1, 2024
• Study Start: January 1, 2022
• Primary Completion: September 30, 2023
• Study Completion: September 30, 2023
• Last Updated: March 1, 2024

Record last verified: 2024-02

Locations

DK (1)