Sensory and Cognitive Predictions, and Their Disruptions in Schizophrenia

NCT06361407 | Recruiting

• 1 other identifier: 2023-A02464-41
• Study Type: interventional
• Target: 68
• Locations: 1 country
• Sites: 2

Brief Summary

Disturbances in the sense of self and time could play an important role in the development of psychotic symptoms. Previous work has shown that patients have difficulty preparing to process information on the scale of a second, but are abnormally disturbed by slightly asynchronous information on the millisecond scale. In both cases, the anomalies could explain the patients' unusual experience of time. The hypothesis in neurotypical patients is that small delays or asynchronies asynchronies are treated as irrelevant information and ignored and ignored, whereas in patients suffering from schizophrenia they would disrupt the flow of time. This hypothesis is tested with a new visual illusion.

Conditions

Schizophrenia; Sensory Processing Disorder

Keywords

sensory prediction; motion perception; prediction error

Outcome Measures

Primary Outcomes (1)

• Effect of a millisecond-level trajectory perturbation

  Change in the rate of illusion in case of a trajectory perturbation (compared to the rate of illusion in the absence of perturbation)

  Month 4

Secondary Outcomes (2)

• Baseline rate of illusion

  month 4

• Effect of a rebound (top-down, conscious influence)

  month 4

Study Arms (1)

effect of trajectory perturbation

EXPERIMENTAL

All participants will run the task consisting in 2 squares moving towards each other. On each trial they will answer whether the squares touch or do not touch. All participants are tested with all experimental conditions. The rate of 'touch' responses will be compared when there is a trajectory perturbation without rebound vs. a trajectory with perturbation with rebound vs. a trajectory without perturbation and without rebound vs. a trajectory without perturbation and with rebound.

Behavioral: Illusion task

Interventions

Illusion task BEHAVIORAL

The task is the illusion already described in the arm description. All participants will additionally benefit from a short neuropsychological evaluation exploring attention (CPT-AX) and semantic knowledge (fNART) and a clinical evaluation exploring the sense of self (EASE).

Also known as: EASE evaluation, fNART, CPT-AX

effect of trajectory perturbation

Eligibility Criteria

• Age: 18 Years - 60 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Male or female;
• Age between 18 and 60 inclusive;
• Subject having dated and signed the consent form prior to the start of any trial-related procedure (guardian or curator where applicable);
• Member of a social security scheme or beneficiary of such a scheme.

You may not qualify if:

• Psychoactive substance use disorders (as defined by the DSM-V) (Diagnostic and Statistical Manual-V);
• Neurological pathology or sequelae;
• Attention deficit hyperactivity disorder (ADHD);
• Borderline personality disorder;
• Disabling sensory disorders (visual acuity \<0.8);
• Person deprived of liberty or under court protection;
• Pregnant, parturient or breast-feeding women;

Sponsors & Collaborators

• Centre Psychothérapique de Nancy: lead
• Institut National de la Santé Et de la Recherche Médicale, France: collaborator

Study Sites (2)

CHU Sainte Marguerite, APHM

Marseille, France

RECRUITING

Centre Hospitalier Drôme Vivarais

Montéléger, France

RECRUITING

MeSH Terms

Conditions

Schizophrenia

Interventions

Neuropsychological Tests

Condition Hierarchy (Ancestors)

Schizophrenia Spectrum and Other Psychotic Disorders; Mental Disorders

Intervention Hierarchy (Ancestors)

Psychological Tests; Behavioral Disciplines and Activities

Study Officials

• Anne Giersch, MD PhD

  Institut National de la Santé Et de la Recherche Médicale, France

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Anne Giersch, MD PhD

CONTACT

0033 3 88 116471; giersch@unistra.fr

Naoual MELLOUKI BENDIMRED, PhD

CONTACT

0383925267; unic@cpn-laxou.com

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Masking Details: The group will be masked at the stage of data analysis. It cannot be masked at the prior stages
• Purpose: BASIC SCIENCE
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Model Details: Individuals with schizophrenia will be tested in parallel with neurotypicals

Study Record Dates

• First Submitted: April 3, 2024
• First Posted: April 11, 2024
• Study Start: June 28, 2024
• Primary Completion (Estimated): October 28, 2027
• Study Completion (Estimated): October 28, 2027
• Last Updated: March 25, 2026

Record last verified: 2026-03

Data Sharing

• IPD Sharing: Will not share

Locations

FR (2)