EEG and Behavioral Correlates of Temporal Prediction in the Tactile Modality in Schizophrenia

NCT05296720 | Recruiting

• 1 other identifier: 021-A02434-37
• Study Type: interventional
• Target: 68
• Locations: 1 country
• Sites: 1

Brief Summary

Patients with schizophrenia have disturbances in their sense of self, particularly their bodily self. Disorders of the sense of self are central to schizophrenia and are of interest because they are thought to be present prior to the development of the disorder, when only a few attenuated symptoms signal a risk of developing psychosis. Finding markers related to the sense of self would make it possible to predict which subjects, among those with minimal psychotic symptoms, will develop psychosis, and thus to better adapt management. Disturbances in the experience of the passage of time that accompany disturbances in the sense of self have been described particularly in subjects at risk of developing psychosis, and would predict the onset of the pathology. However, as with alterations in the sense of self, it can be difficult to get patients to describe their disturbances in the experience of time, and objective measures are required to facilitate detection of these disturbances. In the present protocol an objective measure of temporal perception mechanisms will be tested in relation to the sense of self. The tests used in the protocol assess subjects' abilities to benefit from the passage of time and to use these abilities to predict and prepare for the occurrence of an event. The investigators have previously shown that patients with impaired bodily sense of self do not benefit from the passage of time to prepare themselves to process information in the future. The present protocol is aimed at developing a measure more sensitive to the patients' disorders by adding tactile measures.

Conditions

Schizophrenia

Outcome Measures

Primary Outcomes (1)

• measure of movement speed

  Motor anticipation: The participant moves his or her finger until a tactile stimulation is delivered, and the finger trajectory is recorded by means of a LED on the finger and a camera. The analysis of the trajectory allows for a measure of movement speed, acceleration and deceleration. The anticipation of the need to stop the movement is typically accompanied by a slowing down of the trajectory. The slowing down of the trajectory is used as a proxy for the anticipation of the tactile stimulation. We will measure at what time before the tactile stimulation the deceleration starts.

  month 2

Secondary Outcomes (1)

• Electroencephalographic measure

  month 2

Study Arms (2)

Patients

OTHER

Patients with schizophrenia

Behavioral: Tactile stimulation

Controls

OTHER

Controls matched with patients on age, sex and education level

Behavioral: Tactile stimulation

Interventions

Tactile stimulation BEHAVIORAL

Participants are asked to react as fast as possible to a tactile stimulation

Controls; Patients

Eligibility Criteria

• Age: 18 Years - 60 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Male or Female;
• Age between 18 and 60 years inclusive;
• Subject who has dated and signed the consent form (guardian or custodian prior to the commencement of any trial-related procedures if applicable);
• Enrolled in a social security plan or beneficiary of such a plan.

You may not qualify if:

• Psychoactive substance use disorders (as defined by DSM-V);
• Neurological pathology or sequelae;
• Attention deficit hyperactivity disorder (ADHD);
• A borderline personality disorder;
• Disabling sensory disorders;
• Person deprived of liberty or under court protection;
• Pregnant, parturient or nursing woman;

Sponsors & Collaborators

• Centre Psychothérapique de Nancy: lead

Study Sites (1)

Anne GIERSCH

Strasbourg, France

RECRUITING

MeSH Terms

Conditions

Schizophrenia

Condition Hierarchy (Ancestors)

Schizophrenia Spectrum and Other Psychotic Disorders; Mental Disorders

Study Officials

• Anne GIERSCH, MD, PhD

  Institut National de la Santé Et de la Recherche Médicale, France

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Anne GIERSCH, MD PhD

CONTACT

0388116471; anne.giersch@inserm.fr

Naoual MELLOUKI BENDIM'RED, PhD

CONTACT

0383925267; unic@cpn-laxou.com

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NON RANDOMIZED
• Masking: SINGLE
• Who Masked: OUTCOMES ASSESSOR
• Purpose: BASIC SCIENCE
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: February 17, 2022
• First Posted: March 25, 2022
• Study Start: April 13, 2023
• Primary Completion (Estimated): April 1, 2027
• Study Completion (Estimated): October 1, 2027
• Last Updated: March 25, 2026

Record last verified: 2026-03

Locations

FR (1)