Physical Activity in Children With Wolff-Parkinson-White Syndrome

NCT06349109 | Completed

• 1 other identifier: PA-WPW
• Study Type: observational
• Target: 26
• Locations: 1 country
• Sites: 1

Brief Summary

The aim of this study was to investigate the level of physical activity and its determinants in children with WPW.

Conditions

Wolff-Parkinson-White Syndrome

Outcome Measures

Primary Outcomes (1)

• The Physical Activity Questionnaire for Older Children Score

  The PAQ-C comprises ten items and higher scores indicate a higher level of activity. The first item of the PAQ-C consists of 22 common sports and leisure activities for which the participants select the score based on the frequency of the activity performed during the preceding seven days on a five-point rating scale, after which a mean composite score was calculated. The remaining eight items address physical activities performed during the day, for example, physical education classes, recess time, lunchtime, as well as afterschool activities on weekday evenings and weekends, and finally a summary for all days of the week. The mean score of the first nine items is the summary score of the PAQ-C. The tenth item inquires about any unusual circumstances (e.g., sickness) that affected/prevented the child's physical activity in the seven days preceding the assessment.

  15-20 mins

Secondary Outcomes (9)

• VO2peak

  30-45 minutes

• aPWV

  15-20 minutes

• GLS

  30-45 minutes

• LASr

  30-45 minutes

• LASct

  30-45 minutes

Study Arms (2)

WPW group

Other: Cardiopulmonary exercise test; Other: Atrial-Ventricular Strain Analysis; Other: Arterial Stiffness Measurement; Other: Physical Activity Level; Other: Physical Activity Barriers Assesment

Control Group

Other: Physical Activity Level; Other: Physical Activity Barriers Assesment

Interventions

Cardiopulmonary exercise test OTHER

The cardiopulmonary exercise test (CPET), the gold standard for the assessment of cardiorespiratory fitness, will be used. The Modified Bruce/half Bruce protocol with will be used. In addition, dyspnoea, leg fatigue and general fatigue will be recorded every three minutes at rest, during the test and during the post-test recovery phases using the Modified Borg Scale and blood pressure will be recorded with a sphygmomanometer. The test will be continued until individuals reach the end of the protocol or until the last point at which they wish to stop the test. The test will be terminated if the patient wishes to terminate the test, severe breathlessness, leg fatigue or general fatigue, loss of coordination, progressive chest pain, ST segment elevation or depression of more than 2 mm, oxygen saturation of 80% or less, reaching 85% or more of the predicted heart rate. Oxygen consumption (VO2peak) will be used as the primary outcome measure for cardiorespiratory fitness.

WPW group

Atrial-Ventricular Strain Analysis OTHER

Atrial-Ventricular strain will be evaluated by a specialist physician using Speckle Tracking Echocardiography. During the evaluation, standard echocardiographic measurements will be made with transthoracic echocardiography. With these measurements, images suitable for strain analysis will be obtained. Deformation analysis will be performed using the speckle tracing method for the appropriate images obtained and hemodynamic parameters obtained by the analysis will be recorded.

WPW group

Arterial Stiffness Measurement OTHER

Arterial stiffness will be assessed using the pulse wave velocity (PWV) technique with the Mobile-O-GRAPH (TG) (LE.M., Stolberg, Germany), an oscillometer-based device. After the patients have rested sufficiently, measurements will be taken in an upright sitting position in a quiet and sufficiently bright environment at room temperature, with the device manso placed 2-3 cm above the chiibital fossa in the non-dominant upper limb and the arms raised to the level of the heart. Pulse propagation velocity will be calculated in m/sec with the help of a computer. A high velocity data indicates a high level of arterial stiffening and a low velocity data indicates a low level of arterial stiffening.

WPW group

Physical Activity Level OTHER

Physical activity level will be assessed with the Child Physical Activity Questionnaire.

Control Group; WPW group

Physical Activity Barriers Assesment OTHER

"Physical Activity Outcome Expectancies (child survey)" and "Physical Activity Home Environment Scale (Child)" will be used in children, while " Physical activity barriers (Parent)" will be used in family members.

Control Group; WPW group

Eligibility Criteria

• Age: 7 Years - 18 Years
• Sex: all
• Age Groups: Child (0-17), Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

Patients aged 7-18 years who are followed up by the Department of Paediatrics, Division of Paediatric Cardiology, Faculty of Medicine of a university will be included in the study.

You may qualify if:

• Being between 7-18 years old
• Ensuring clinical stability in patients
• No change in drug therapy, if any, that adversely affects clinical stability

You may not qualify if:

• Neurological and/or genetic musculoskeletal disorders
• Diagnosed orthopaedic and cognitive problems that prevent the tests from being performed
• History before 4 weeks of cardiac or other body system problems
• The patient and/or his/her family does not want to be included in the study

Sponsors & Collaborators

• Karamanoğlu Mehmetbey University: lead

Study Sites (1)

Hacettepe University

Ankara, Turkey (Türkiye)

Location

MeSH Terms

Conditions

Wolff-Parkinson-White Syndrome

Interventions

Exercise Test

Condition Hierarchy (Ancestors)

Pre-Excitation Syndromes; Arrhythmias, Cardiac; Heart Diseases; Cardiovascular Diseases; Cardiac Conduction System Disease; Heart Defects, Congenital; Cardiovascular Abnormalities; Congenital Abnormalities; Congenital, Hereditary, and Neonatal Diseases and Abnormalities

Intervention Hierarchy (Ancestors)

Heart Function Tests; Diagnostic Techniques, Cardiovascular; Diagnostic Techniques and Procedures; Diagnosis; Respiratory Function Tests; Diagnostic Techniques, Respiratory System; Ergometry; Investigative Techniques

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Research assistant, PhD

Study Record Dates

• First Submitted: March 30, 2024
• First Posted: April 5, 2024
• Study Start: March 1, 2024
• Primary Completion: December 1, 2024
• Study Completion: December 1, 2024
• Last Updated: January 29, 2025

Record last verified: 2025-01

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)