Cardiopulmonary Exercise Testing in Girls (8-18y) with Turner Sydrome.

NCT06780514 | Recruiting

• 1 other identifier: ONZ-2023-0632
• Study Type: interventional
• Target: 20
• Locations: 1 country
• Sites: 1

Brief Summary

The goal of this clinical trial is to have a beter insight in the exercise tolerance in girls with Turner Syndrome aged 8-18 years . The main question it aims to answer is: Is there a difference in VO2 max comparing Turner syndrome girls with standard values? How do cardiovascular parameters change during exercise (heart rate, bloodpressure, ...) Participants will perform a cyclo-ergometry in a standardised way.

Conditions

Turner Syndrome

Keywords

Cardiopulmonary exercise test

Outcome Measures

Primary Outcomes (1)

• VO2 max

  VO2 max is the maximum volume (V) of oxygen (O2) your body can process during exercise

  Whitin a week after the CPET

Secondary Outcomes (2)

• Bloodpressure

  Whitin a week after the CPET

• Heart rate

  Whitin a week after the CPET

Interventions

Cardiopulmonary exercise test DIAGNOSTIC_TEST

To our knowledge, this is the first study to perform CPET's in Turner Girls aged \<18 years

Also known as: CPET, cyclo-ergometry

Eligibility Criteria

• Age: 8 Years - 18 Years
• Sex: female
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64)

You may qualify if:

• Turner syndrome girls aged 8-18 years old

You may not qualify if:

• Severe mental impairement making it impossible to perform an exercise test

Sponsors & Collaborators

• University Hospital, Ghent: lead

Study Sites (1)

Ghent University Hospital

Ghent, 9000, Belgium

RECRUITING

MeSH Terms

Conditions

Turner Syndrome

Interventions

Exercise Test

Condition Hierarchy (Ancestors)

Gonadal Dysgenesis; Disorders of Sex Development; Urogenital Abnormalities; Female Urogenital Diseases; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Sex Chromosome Disorders of Sex Development; Male Urogenital Diseases; Heart Defects, Congenital; Cardiovascular Abnormalities; Cardiovascular Diseases; Heart Diseases; Congenital Abnormalities; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Sex Chromosome Disorders; Chromosome Disorders; Genetic Diseases, Inborn; Gonadal Disorders; Endocrine System Diseases

Intervention Hierarchy (Ancestors)

Heart Function Tests; Diagnostic Techniques, Cardiovascular; Diagnostic Techniques and Procedures; Diagnosis; Respiratory Function Tests; Diagnostic Techniques, Respiratory System; Ergometry; Investigative Techniques

Central Study Contacts

Dr. Debo

CONTACT

093329813; bauke.debo@uzgent.be

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: DIAGNOSTIC
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: January 13, 2025
• First Posted: January 17, 2025
• Study Start: January 31, 2024
• Primary Completion (Estimated): July 30, 2026
• Study Completion (Estimated): July 30, 2026
• Last Updated: January 17, 2025

Record last verified: 2025-01

Data Sharing

• IPD Sharing: Will not share

Locations

BE (1)