Accessory Pathway Antegrade Effective Refractory Period Among WPW Patients: the Risk in Relation to the Location

NCT04106622 | Unknown

• 1 other identifier: WPW syndrome
• Study Type: observational
• Target: 35
• Locations: 0 countries
• Sites: N/A

Brief Summary

To correlate the antegrade effective refractory period of the accessory pathway with its anatomical location in the heart. To investigate whether the accessory pathway location can predict the high risk nature of the accessory pathway

Conditions

Wolff-Parkinson-White Syndrome

Keywords

Wolff-Parkinson-White Syndrome

Outcome Measures

Primary Outcomes (1)

• the antegrade refractory period during invasive EPS done for the patients

  the values will be correlated to the site of the AP diagnosed be EPS.. according to the previous studies and the current guidelines, if the refractory period is \< 250 ms, this is considered a high risk AP

  2 hours

Study Arms (1)

Wolff Parkinson White patients

The investigators will decide the location of the AP by: \- Invasively: if the patient is subjected to (EPS) • There are different locations of AP To assess whether the AP is of high risk or not, for all patients the Antegrade refractory period of the APAERP of the AP will be determined by one of the following ways: ( AERP) is measured during EPS as the shortest cycle length with one-to-one conduction over the AP by incremental atrial stimulation after which the QRS becomes narrow or no conduction occurs due to block of the impulse in the AP. The shortest pre-excited R-R interval (SPERRI) during spontaneous or induced AF. The AERP and the risk category of the AP according to its value, will be recorded in relation to the site of the AP determined in every case and compared between different accessory Locations to see whether some of these positions are more liable to be of higher risk or there is no differerence between different positions.

Procedure: electrophysiological study

Interventions

electrophysiological study PROCEDURE

To assess whether the AP is of high risk or not, for all patients the AERP of the AP will be determined by one of the following ways: The cycle length at which abrupt and complete loss of pre-excitation occurs during exercise test. If this didn't happen, the patient will be subjected to invasive electrophysiologic study.. The Antegrade refractory period of the AP is measured during EPS as the shortest cycle length with one-to-one conduction over the AP by incremental atrial stimulation after which the QRS becomes narrow or no conduction occurs due to block of the impulse in the AP. The shortest pre-excited R-R interval during spontaneous or induced AF.

Wolff Parkinson White patients

Eligibility Criteria

• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Wolff Parkinson White patients

You may qualify if:

• all patients with WPW admitted to Assuit university hospital and subjected to invasive EPS

You may not qualify if:

• heart failure
• cardiomyopathy

Sponsors & Collaborators

• Assiut University: lead

MeSH Terms

Conditions

Wolff-Parkinson-White Syndrome

Condition Hierarchy (Ancestors)

Pre-Excitation Syndromes; Arrhythmias, Cardiac; Heart Diseases; Cardiovascular Diseases; Cardiac Conduction System Disease; Heart Defects, Congenital; Cardiovascular Abnormalities; Congenital Abnormalities; Congenital, Hereditary, and Neonatal Diseases and Abnormalities

Study Officials

• M K Ibrahim, Msc

  Assiut University

  PRINCIPAL INVESTIGATOR

• S S Atta, Professor

  Assiut University

  STUDY DIRECTOR

• S M Taha, Lecturer

  Assiut University

  STUDY DIRECTOR

Central Study Contacts

M K Ibrahim, Msc

CONTACT

1152453334; mohamed011354@med.au.edu.eg

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: CROSS SECTIONAL
• Target Duration: 1 Month
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal investigator

Study Record Dates

• First Submitted: September 25, 2019
• First Posted: September 27, 2019
• Study Start: March 1, 2020
• Primary Completion: March 1, 2022
• Study Completion: March 1, 2023
• Last Updated: January 30, 2020

Record last verified: 2020-01