NCT06315218

Brief Summary

This research study aims to test the effectiveness, reach, and maintenance over time of the NPOWER365 HIV care intervention for Black men who have sex with men (BMSM) living with HIV. NPOWER365 is a BMSM community-developed multicomponent intervention that aims to: 1) Support daily health promotion via HIV health education and health maintenance reminders; 2) Foster positive social connections among BMSM via online moderated forums, interpersonal chats, and community calendars; 3) Connect clients to BMSM-affirming healthcare, including HIV treatment and mental healthcare; 4) Provide resources for housing, transportation, and other economic empowerment.

Trial Health

65
Monitor

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
350

participants targeted

Target at P75+ for not_applicable

Timeline
23mo left

Started Mar 2026

Typical duration for not_applicable

Status
not yet recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Progress9%
Mar 2026Apr 2028

First Submitted

Initial submission to the registry

March 11, 2024

Completed
7 days until next milestone

First Posted

Study publicly available on registry

March 18, 2024

Completed
2 years until next milestone

Study Start

First participant enrolled

March 1, 2026

Completed
2.1 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

April 1, 2028

Expected
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

April 1, 2028

Last Updated

February 19, 2026

Status Verified

February 1, 2026

Enrollment Period

2.1 years

First QC Date

March 11, 2024

Last Update Submit

February 17, 2026

Conditions

Outcome Measures

Primary Outcomes (2)

  • Antiretroviral (ART) Medication Use

    For daily surveys, participants will report ART adherence on a single binary item ("In the past 24 hours did the participant take ART medication?")

    24 hours

  • ART adherence-Long Lag Assessments

    The investigators will use the NAME scale that assesses barriers to ART adherence.

    2 weeks

Secondary Outcomes (10)

  • Daily Diary Substance Use

    24 hours

  • Substance Use-Long Lag Assessments

    2 weeks

  • Depressive Symptoms

    24 hours

  • Depressive Symptoms-Long Lag

    2 weeks

  • Anxiety Symptoms

    24 hours

  • +5 more secondary outcomes

Study Arms (2)

Intervention Arm

EXPERIMENTAL

NPOWER365 is a multicomponent intervention that combines mHealth features and institutional to support community priorities identified in formative CBPR. In line with best practices for trials of intervention principles (TIPs) with mHealth interventions, NPOWER365 deploys intervention elements that serve to accomplish intervention strategies. NPOWER365 intervention strategies are to promote: 1)Health knowledge and motivation; 2)Social support coping; 3)Access to culturally-affirming healthcare; and 4)Housing and other economic resources. NPOWER365 pursues these strategies via these intervention elements: 1)Weekly HIV and psychological health information and motivation content and daily health notifications; 2)Online moderated forums, interpersonal chats, and community calendars; 3)Linkage to biopsychosocial healthcare via NAESM's network of Black SGLM-affirming providers; and 4)Housing and economic resources through NAESM's direct support and referral network.

Behavioral: NPOWER365 HIV care intervention

Control Arm

NO INTERVENTION

The 6-month waitlist control group will have access only to NAESM services not covered by NPOWER365, such as in-person events. The investigators will ensure the control group does not access the NPOWER365 mHealth app portion by screening all new app users, giving the intervention group unique private log-ins, and explaining the importance of securing those log-ins to ensure the accuracy of study results.

Interventions

NPOWER365 is a multicomponent intervention that combines mHealth features and institutional to support community priorities identified in formative CBPR. In line with best-practices for trials of intervention principles (TIPs) with mHealth interventions, NPOWER365 deploys intervention elements that serve to accomplish intervention strategies. NPOWER365 intervention strategies are to promote: 1)Health knowledge and motivation; 2)Social support coping; 3)Access to culturally-affirming healthcare; and 4)Housing and other economic resources. NPOWER365 pursues these strategies via these intervention elements: 1)Weekly HIV and psychological health information and motivation content and daily health notifications; 2)Online moderated forums, interpersonal chats, and community calendars; 3)Linkage to biopsychosocial healthcare via NAESM's network of Black SGLM-affirming providers; and 4)Housing and economic resources through NAESM's direct support and referral network.

Intervention Arm

Eligibility Criteria

Age18 Years+
Sexall(Gender-based eligibility)
Gender Eligibility DetailsAnyone that identifies as a man.
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Identify as Black or African American, regardless of ethnicity
  • Identify as male, regardless of sex assigned at birth
  • Are living with HIV and prescribed a daily ART regimen
  • Are age ≥ 18;
  • Have sex with men
  • Own an internet-connected device (e.g., smartphone, tablet)
  • Reside in the Atlanta-area EHE jurisdictions.

You may not qualify if:

  • Lack of English fluency
  • Past participation in the pilot.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Related Publications (2)

  • English D, Smith JC, Scott-Walker L, Lopez FG, Morris M, Reid M, Lashay C, Bridges D, McNeish D. Feasibility, Acceptability, and Preliminary HIV Care and Psychological Health Effects of iTHRIVE 365 for Black Same Gender Loving Men. J Acquir Immune Defic Syndr. 2023 May 1;93(1):55-63. doi: 10.1097/QAI.0000000000003167.

  • English D, Smith JC, Scott-Walker L, Lopez FG, Morris M, Reid M, Lashay C, Bridges D, Rosales A, Cunningham DJ. iTHRIVE 365: A Community-Led, Multicomponent Health Promotion Intervention for Black Same Gender Loving Men. Ann LGBTQ Public Popul Health. 2023 Dec;4(4):363-383. doi: 10.1891/lgbtq-2022-0009.

Related Links

MeSH Terms

Conditions

CoitusSocial StigmaMedication AdherenceDepressionAnxiety Disorders

Condition Hierarchy (Ancestors)

Sexual BehaviorBehaviorSocial BehaviorPatient CompliancePatient Acceptance of Health CareTreatment Adherence and ComplianceHealth BehaviorBehavioral SymptomsMental Disorders

Study Officials

  • Devin English, Ph.D.

    Rutgers University

    PRINCIPAL INVESTIGATOR
  • Justin Smith, MS, MPH

    Positive Impact Health Centers

    PRINCIPAL INVESTIGATOR

Central Study Contacts

Devin English, Ph.D.

CONTACT

Emmanuel Chavez, MS

CONTACT

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
SINGLE
Who Masked
PARTICIPANT
Purpose
SUPPORTIVE CARE
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Devin English, PhD; Assistant Professor

Study Record Dates

First Submitted

March 11, 2024

First Posted

March 18, 2024

Study Start

March 1, 2026

Primary Completion (Estimated)

April 1, 2028

Study Completion (Estimated)

April 1, 2028

Last Updated

February 19, 2026

Record last verified: 2026-02

Data Sharing

IPD Sharing
Will share

Outside researchers will be able to request access to these de-identified data through email to the PI in order to conduct analyses for which the PI and study team do not have expertise. This request will be considered by the PI, the appropriate officers at Rutgers University for processing. As such, the PI will initiate a DTA, and seek the legal advice of Rutgers University regarding the adequacy of compliance with any relevant laws, policies, or regulations. If approved, data will be completely de-identified and shared through a secure sharing mechanism (e.g., password protected and encrypted online database for electronic data). No participant codes will be shared with external researchers.

Shared Documents
STUDY PROTOCOL, SAP
Time Frame
Data will only be shared with other researchers who have received IRB approval and who will destroy or return dataset information after completing their analyses.
Access Criteria
Data will only be shared with other researchers who have received IRB approval and who will destroy or return dataset information after completing their analyses.