Gingival Crevicular Fluid (GCF) Bactericidal Permeability Protein (BPI) and Interleukin (IL)-1 Beta

NCT06295666 | Completed

• 1 other identifier: 26.12.2018/901
• Study Type: observational
• Target: 100
• Locations: 1 country
• Sites: 1

Brief Summary

Objective: The aim of this study is to determine the amounts of BPI (Bactericidal permeability protein) and interleukin-1beta (IL-1β) in gingival fluid samples obtained from individuals with periodontally healthy and periodontal disease, to compare these amounts between study groups, and to evaluate their relationship with clinical parameters. In cases where clinical parameters increase, IL-1β amounts also increase significantly. The amount of IL-1β in individuals with periodontal disease is significantly higher compared to healthy individuals. There is positive correlation between BPI and clinical parameters. The amount of BPI in individuals with periodontal disease is significantly higher than in healthy individuals. More studies are needed to better understand the importance and therapeutic effect of BPI in periodontitis

Conditions

Periodontitis; Gingival Crevicular Fluid; Interleukin 1-beta; Bactericidal Permeability Protein

Outcome Measures

Primary Outcomes (1)

• Gingival Crevicular Fluid Bactericidal Permeability Increasing Protein levels in periodonitis

  Protein levels that increase gingival crevicular fluid bactericidal permeability are expected to increase in the periodontitis group.

  through study completion, an average of 1 year

Study Arms (2)

Healty

Periodontal healty group

Periodontitis

Periodontitis group

Eligibility Criteria

• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients who applied to Akdeniz University Faculty of Dentistry Department of Periodontology between 19/02/2019 and 25/11/2019 were included.

You may qualify if:

• For the periodontitis group, intraoral examination shows inflammation in the gums, supragingival and by observing the formation of subgingival tartar and microbial dental plaque and pockets, Diagnosis of periodontitis means that there is a vertical or detection of horizontal bone loss (Periodontitis group),
• Failure to observe the presence of periodontal pockets, vertical and horizontal no bone destruction, bleeding score on full-mouth probing below 10 percent (Healthy group),
• Agreeing to participate in the research and filling out and signing the voluntary consent form.

You may not qualify if:

• Pregnant and lactating individuals,
• Individuals who smoke,
• Individuals with any systemic disease,
• Individuals who have received periodontal treatment in the last 6 months,
• Individuals who have used antibiotics in the last 6 months
• Individuals in whom local factors that increase destruction such as fillings and crowns are observed in areas with periodontal pocket formation.

Sponsors & Collaborators

• Akdeniz University: lead

Study Sites (1)

Akdeniz Üniversitesi Diş Hekimliği Fakültesi

Antalya, Turkey (Türkiye)

Location

Biospecimen

Retention: SAMPLES WITHOUT DNA

Gingival Crevicular Fluid

MeSH Terms

Conditions

Periodontitis

Condition Hierarchy (Ancestors)

Periodontal Diseases; Mouth Diseases; Stomatognathic Diseases

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Clinical Professor

Study Record Dates

• First Submitted: January 2, 2024
• First Posted: March 6, 2024
• Study Start: February 19, 2019
• Primary Completion: November 25, 2019
• Study Completion: January 20, 2020
• Last Updated: March 6, 2024

Record last verified: 2024-03

Locations

TU (1)