Resolvin D1 Levels in Patients With Periodontitis
The Role of Resolvin D1 in Maintaining Oral Health
1 other identifier
interventional
26
1 country
1
Brief Summary
The purpose of the study was to determine the levels of Resolvin D1 (RVD1) in the gingival crevicular fluid (GCF) and saliva of the patients with periodontitis (P) and also to investigate the effects of non-surgical periodontal treatments (NSPTs) on its levels. A total of 26 subjects (15 P, 11 healthy) were included. Clinical periodontal measurements, GCF and saliva samples were collected from each individual at baseline and 1 month after NSPTs in P group. RVD1 levels were determined by enzyme-linked immunosorbent assay (ELISA) method.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at below P25 for not_applicable
Started Jul 2019
Shorter than P25 for not_applicable
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
July 31, 2019
CompletedPrimary Completion
Last participant's last visit for primary outcome
February 29, 2020
CompletedStudy Completion
Last participant's last visit for all outcomes
February 29, 2020
CompletedFirst Submitted
Initial submission to the registry
July 29, 2020
CompletedFirst Posted
Study publicly available on registry
August 3, 2020
CompletedAugust 19, 2020
August 1, 2020
7 months
July 29, 2020
August 17, 2020
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Biochemical parameter (resolvin D1)
The changes in levels of resolvin D1 after periodontal treatment determined by ELISA.
Baseline and 1 month after NSPT
Secondary Outcomes (4)
Probing pocket depth
Baseline and 1 month after NSPT
Clinical attachment level (CAL)
Baseline and 1 month after NSPT
Plaque index (PI)
Baseline and 1 month after NSPT
Gingival index (GI)
Baseline and 1 month after NSPT
Study Arms (2)
Periodontitis patients
ACTIVE COMPARATORgingival crevicular fluid and saliva collection were taken before and after nonsurgical periodontal treatment
Healthy individuals
NO INTERVENTIONgingival crevicular fluid and saliva collection were taken at baseline after oral hygiene instructions
Interventions
Non surgical periodontal therapy was performed to patients with peridontitis
Eligibility Criteria
You may qualify if:
- Stage 3, Grade B and generalized periodontitis patients
You may not qualify if:
- excessive forces;
- presence of systemic diseases
- administration of non-steroidal and anti-inflammatory drugs or antibiotic therapies within the previous 6 months
- having received non-surgical periodontal treatment within the past 6 months
- allergy or sensitivity to any drug,
- pregnancy, lactation
- current and former use of tobacco.
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- Ordu Universitylead
Study Sites (1)
Ordu University
Ordu, 52200, Turkey (Türkiye)
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- NON RANDOMIZED
- Masking
- NONE
- Purpose
- DIAGNOSTIC
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Principal investigator
Study Record Dates
First Submitted
July 29, 2020
First Posted
August 3, 2020
Study Start
July 31, 2019
Primary Completion
February 29, 2020
Study Completion
February 29, 2020
Last Updated
August 19, 2020
Record last verified: 2020-08