Effect of Aloe Vera Gel as an Intra Canal Medicament

NCT06243601 | Completed DMC

• 1 other identifier: IslamabadDentalHospital
• Study Type: interventional
• Target: 60
• Locations: 1 country
• Sites: 1

Brief Summary

This research will overview the effect of aloe vera gel (AVG) as intra canal medicament in patients with asymptomatic periapical lesions. It will provide endodontists with scientific evidence regarding the beneficial use of AVG as an intracanal medicament owing to its superior antibacterial and analgesic properties as compared to routinely used commercial intra canal medicaments.

Conditions

Periapical Diseases

Keywords

Antibacterial, Analgesic, Clinical signs and symptoms

Outcome Measures

Primary Outcomes (1)

• Presence or absence of signs and symptoms of the patient

  Patients in both the groups will be recalled after one week. They will be assessed clinically for either presence or absence of signs and symptoms. 1. In cases of absence of clinical signs and symptoms, endodontic treatment will be completed. 2. In cases where patient returns with presence of clinical signs and symptoms, dressing will be removed, and canals will be irrigated with sodium hypochlorite followed by saline. After drying the canals, in group A, AVG will be placed in the canals and tooth restored temporarily while in group B, cotton pellet will be placed in the canals and tooth restored temporarily. The patients will be recalled after two weeks. 3. If a patient reports with acute symptomsin either of the groups, the protocols to manage acute infection will be followed.

  One week and 3 weeks

Study Arms (2)

Intervention Group

EXPERIMENTAL

Fresh AVG will be prepared. It will be placed as intracanal medicament after cleaning and shaping in patients with asymptomatic periapical lesions

Biological: Aloe vera Gel

Control Group

NO INTERVENTION

No intracanal medicament will be placed

Interventions

Aloe vera Gel BIOLOGICAL

A fresh aloe vera (Aloe Barbadensis) leaf will be plucked from the plant. The leaf will be washed with normal saline, peeled with scalpel and the inner gel will be blended in a blender to convert it into a watery consistency. The solution will be stored in an autoclaved flask.

Intervention Group

Eligibility Criteria

• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)

You may qualify if:

• Both male and female patients presenting with asymptomatic periapical lesions in permanent teeth

You may not qualify if:

• History of allergy to AVG
• Comorbidities likely to impair healing
• Pregnant women
• History of previous endodontic treatment in the same tooth
• Presence of pulp calcification
• Internal or external root resorption

Sponsors & Collaborators

• Islamabad Medical and Dental College: lead

Study Sites (1)

Islamabad Dental Hospital

Islamabad, Federal, 44000, Pakistan

Location

MeSH Terms

Conditions

Periapical Diseases; Signs and Symptoms

Interventions

Aloe vera gel

Condition Hierarchy (Ancestors)

Jaw Diseases; Stomatognathic Diseases; Periodontal Diseases; Mouth Diseases; Pathological Conditions, Signs and Symptoms

Study Officials

• Saima Azam, BDS,FCPS

  Islamabad Dental Hospital

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: OUTCOMES ASSESSOR
• Purpose: TREATMENT
• Intervention Model: SEQUENTIAL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: January 29, 2024
• First Posted: February 6, 2024
• Study Start: November 30, 2023
• Primary Completion: August 20, 2024
• Study Completion: November 15, 2024
• Last Updated: May 21, 2025

Record last verified: 2025-05

Data Sharing

• IPD Sharing: Will not share

Locations

PA (1)