Research of the Application of Triple Antibiotic Paste in Primary Teeth With Pericpical Periodontitis
Randomized Controlled Research of the Application of Triple Antibiotic Paste in Primary Teeth With
1 other identifier
interventional
100
1 country
1
Brief Summary
The triple antibiotic paste is widely used in young permanent teeth and permanent teeth root canal therapy with excellent antiantimicrobial effect.We hypothesize that its application in the treatment of periapical periodontitis of deciduous teeth is superior to other drugs currently in use as creosote.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P50-P75 for not_applicable
Started Jun 2013
Typical duration for not_applicable
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
June 1, 2013
CompletedFirst Submitted
Initial submission to the registry
July 17, 2014
CompletedFirst Posted
Study publicly available on registry
July 22, 2014
CompletedPrimary Completion
Last participant's last visit for primary outcome
December 1, 2014
CompletedStudy Completion
Last participant's last visit for all outcomes
June 1, 2015
CompletedJuly 22, 2014
July 1, 2014
1.5 years
July 17, 2014
July 21, 2014
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Evidence of lesion healing confirmed by cone beam computed tomography and X-rays
1 year
Study Arms (2)
creosote
ACTIVE COMPARATORCreosote ，once，three weeks Triple Antibiotic Paste ，none
Triple Antibiotic Paste
EXPERIMENTALTriple Antibiotic Paste,once,three weeks creosote,none
Interventions
Pulp removal,Root canal irrigation and disinfection,
Pulp removal,Root canal irrigation and disinfection
Eligibility Criteria
You may qualify if:
- clinical diagnosis of periapical periodontitis
- must be primary teeth
- must be 3\~8 years old
- the permanent tooth germ is complete and didnot be involved
You may not qualify if:
- blood disease
- residual root that is advised to extract
- serious periodontitis
- allergy to the triple antibiotic paste
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- Lin Jiachenglead
Study Sites (1)
Jicheng Lin
Guangzhou, Guangdong, 510055, China
Related Publications (3)
Bezgin T, Yilmaz AD, Celik BN, Sonmez H. Concentrated platelet-rich plasma used in root canal revascularization: 2 case reports. Int Endod J. 2014 Jan;47(1):41-9. doi: 10.1111/iej.12144. Epub 2013 Jun 17.
PMID: 23772873BACKGROUNDNagata JY, Gomes BP, Rocha Lima TF, Murakami LS, de Faria DE, Campos GR, de Souza-Filho FJ, Soares Ade J. Traumatized immature teeth treated with 2 protocols of pulp revascularization. J Endod. 2014 May;40(5):606-12. doi: 10.1016/j.joen.2014.01.032. Epub 2014 Mar 6.
PMID: 24767551BACKGROUNDNagata JY, Soares AJ, Souza-Filho FJ, Zaia AA, Ferraz CC, Almeida JF, Gomes BP. Microbial evaluation of traumatized teeth treated with triple antibiotic paste or calcium hydroxide with 2% chlorhexidine gel in pulp revascularization. J Endod. 2014 Jun;40(6):778-83. doi: 10.1016/j.joen.2014.01.038. Epub 2014 Apr 29.
PMID: 24862703BACKGROUND
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Study Officials
- STUDY CHAIR
Jiacheng Lin
Guanghua hospital of stomotology,Sun Yat-sen University
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- SINGLE
- Who Masked
- PARTICIPANT
- Purpose
- TREATMENT
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR INVESTIGATOR
- PI Title
- Research Associate
Study Record Dates
First Submitted
July 17, 2014
First Posted
July 22, 2014
Study Start
June 1, 2013
Primary Completion
December 1, 2014
Study Completion
June 1, 2015
Last Updated
July 22, 2014
Record last verified: 2014-07