NCT02583750

Brief Summary

This project investigated how glucose metabolism differs due to sleep deprivation for three consecutive nights as compared to sufficient sleep for three nights by examining concentrations of glucose, insulin, and other factors involved in glucose metabolism.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
16

participants targeted

Target at below P25 for not_applicable

Timeline
Completed

Started Jan 2014

Shorter than P25 for not_applicable

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

Study Start

First participant enrolled

January 1, 2014

Completed
7 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

August 1, 2014

Completed
1 month until next milestone

Study Completion

Last participant's last visit for all outcomes

September 1, 2014

Completed
1.1 years until next milestone

First Submitted

Initial submission to the registry

October 15, 2015

Completed
7 days until next milestone

First Posted

Study publicly available on registry

October 22, 2015

Completed
Last Updated

October 22, 2015

Status Verified

October 1, 2015

Enrollment Period

7 months

First QC Date

October 15, 2015

Last Update Submit

October 20, 2015

Conditions

Keywords

glucose metabolismsleep deprivation

Outcome Measures

Primary Outcomes (1)

  • Glucose concentrations during oral glucose tolerance test

    two hours

Study Arms (2)

OGTT after deprived sleep first

EXPERIMENTAL

Participants came to the lab to perform the oral glucose tolerance test after three nights of sleep deprivation, then another test after three nights of sufficient sleep

Behavioral: OGTT after deprived sleep first

OGTT after sufficient sleep first

EXPERIMENTAL

Participants came to the lab to perform the oral glucose tolerance test after three nights of sufficient sleep, then another test after three nights of deprived sleep

Behavioral: OGTT after sufficient sleep first

Interventions

Participants slept 1-3 hours less than their normal amount for three nights, and then came to the lab for the oral glucose tolerance testing after a 12 hour overnight fast. The second oral glucose tolerance test was after they slept as much as they wanted for three nights.

OGTT after deprived sleep first

Participants slept as much as they wanted for three nights, and then came to the lab for the oral glucose tolerance testing after a 12 hour overnight fast. The second oral glucose tolerance test was after they slept 1-3 hours less than normal for three nights.

OGTT after sufficient sleep first

Eligibility Criteria

Age18 Years - 25 Years
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64)

You may qualify if:

  • healthy college-aged males and females
  • being minimally active

You may not qualify if:

  • average more than 15,000 steps a day
  • major health issues such as heart disease, diabetes
  • taking medication to help with sleep or using a sleeping device
  • any type of sleep problem such as sleep apnea

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Public Health Research Center University of South Carolina

Columbia, South Carolina, 29201, United States

Location

MeSH Terms

Conditions

Glucose Metabolism DisordersSleep Deprivation

Condition Hierarchy (Ancestors)

Metabolic DiseasesNutritional and Metabolic DiseasesDyssomniasSleep Wake DisordersNervous System DiseasesNeurologic ManifestationsSigns and SymptomsPathological Conditions, Signs and SymptomsMental Disorders

Study Officials

  • Xuewen Wang, PhD

    University of South Carolina

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
interventional
Phase
not applicable
Allocation
NON RANDOMIZED
Masking
NONE
Purpose
HEALTH SERVICES RESEARCH
Intervention Model
CROSSOVER
Sponsor Type
OTHER
Responsible Party
SPONSOR INVESTIGATOR
PI Title
Dr. Xuewen Wang, PhD.

Study Record Dates

First Submitted

October 15, 2015

First Posted

October 22, 2015

Study Start

January 1, 2014

Primary Completion

August 1, 2014

Study Completion

September 1, 2014

Last Updated

October 22, 2015

Record last verified: 2015-10

Locations