Evaluation of the Corneal Endothelial Cell Layer by Specular Microscopy in Patients With Thyroid Eye Disease

NCT06235372 | Unknown

• 1 other identifier: Specular microscopy in TED
• Study Type: observational
• Target: 30
• Locations: 0 countries
• Sites: N/A

Brief Summary

To investigate corneal endothelial cell layer damage by specular microscopy in patients with thyroid eye disease

Conditions

Thyroid Eye Disease

Outcome Measures

Primary Outcomes (1)

• Damage of the corneal endothelial cells in patients with thyroid eye disease by specular microscopy

  To detect if there is any change in corneal endothelial cell layer in patients with thyroid eye disease

  Baseline

Interventions

Specular microscopy DEVICE

Specular microscopy is a noninvasive photographic technique that analyze the corneal endothelium. Using computer-assisted morphometry, modern specular microscopes analyze the size, shape and population of the endothelial cells. The instrument projects light onto the cornea and captures the image that is reflected from the optical interface between the corneal endothelium and the aqueous humor. The reflected image is analyzed by the instrument and displayed as a specular photomicrograph .

Eligibility Criteria

• Age: 12 Years - 80 Years
• Sex: all
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients with thyroid eye disease whom diagnosis was established based on bartley diagnostic criteria .

You may qualify if:

• Patients with thyroid eye disease whom diagnosis was established based on bartley diagnostic criteria .

You may not qualify if:

• participates with systemic diseases other than HT such as
• diabetes mellitus
• previous ocular surgery or laser therapy.
• history of corneal disease.
• history of trauma.
• history of glaucoma

Sponsors & Collaborators

• Assiut University: lead

MeSH Terms

Conditions

Graves Ophthalmopathy

Condition Hierarchy (Ancestors)

Eye Diseases, Hereditary; Eye Diseases; Graves Disease; Exophthalmos; Orbital Diseases; Genetic Diseases, Inborn; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Goiter; Thyroid Diseases; Endocrine System Diseases; Hyperthyroidism; Autoimmune Diseases; Immune System Diseases

Study Officials

• Dalia Mohammed, Professor

  Academic organizations

  STUDY DIRECTOR

• Khaled Abdelazim, Assistant professor

  Academic organizations

  STUDY DIRECTOR

• Ahmed Abdelnasser, Lecturer

  Academic organizations

  STUDY DIRECTOR

Central Study Contacts

Mayar Ashraf, Resident

CONTACT

+201024240738; mayarahrafs7777@gmail.com

Study Design

• Study Type: observational
• Observational Model: OTHER
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal investigator

Study Record Dates

• First Submitted: December 22, 2023
• First Posted: January 31, 2024
• Study Start: March 21, 2024
• Primary Completion: October 22, 2025
• Study Completion: December 22, 2025
• Last Updated: March 20, 2024

Record last verified: 2024-01