Key Insights

Highlights

Success Rate

79% trial completion

Published Results

14 trials with published results (20%)

Clinical Risk Assessment

Based on trial outcomes

Moderate Risk

Score: 39/100

Termination Rate

11.3%

8 terminated out of 71 trials

Success Rate

78.9%

-7.6% vs benchmark

Late-Stage Pipeline

41%

29 trials in Phase 3/4

Results Transparency

47%

14 of 30 completed with results

Key Signals

14 with results79% success

Data Visualizations

Phase Distribution

57Total
Not Applicable (6)
P 1 (10)
P 2 (12)
P 3 (22)
P 4 (7)

Trial Status

Completed30
Recruiting10
Not Yet Recruiting8
Terminated8
Active Not Recruiting6
Unknown6

Trial Success Rate

78.9%

Benchmark: 86.6%

Based on 30 completed trials

Clinical Trials (71)

Showing 20 of 20 trials
NCT05276063Phase 2CompletedPrimary

A Phase 2b, Study of Linsitinib in Subjects With Active, Moderate to Severe Thyroid Eye Disease (TED)

NCT07835607RecruitingPrimary

Comparative Evaluation of 68Ga-FAPI and 68Ga-DOTATATE PET/CT and PET/MRI in Thyroid Eye Disease

NCT07832136Phase 4Not Yet RecruitingPrimary

An Open-Label Trial of Veligrotug in Participants With Thyroid Eye Disease Who Previously Responded to Teprotumumab

NCT06557850Phase 1Active Not RecruitingPrimary

A Trial Investigating Lu AG22515 in Adult Participants With Moderate-to-Severe Thyroid Eye Disease

NCT05002998Phase 4CompletedPrimary

TEPEZZA® (Teprotumumab-trbw) Post-Marketing Requirement Study

NCT06625411Phase 3Active Not RecruitingPrimary

An Efficacy, Safety, and Tolerability Study of VRDN-003 in Participants With Active Thyroid Eye Disease (TED)

NCT06625398Phase 3Active Not RecruitingPrimary

An Efficacy, Safety, and Tolerability Study of VRDN-003 in Participants With Chronic Thyroid Eye Disease (TED)

NCT06179875Phase 3CompletedPrimary

An Open-label Study (OLE) for Non-responders of VRDN-001-101 and VRDN-001-301

NCT06384547Phase 3CompletedPrimary

A Randomized, Controlled, Safety and Tolerability Study of VRDN-001 in Participants With Thyroid Eye Disease (TED)

NCT05176639Phase 3CompletedPrimary

A Safety, Tolerability, and Efficacy Study of Veligrotug (VRDN 001) in Participants With Thyroid Eye Disease (TED)

NCT07762105Phase 1Not Yet RecruitingPrimary

Study of Atorvastatin and Its Effects in Clinical and Radiological Aspects in Patients With Moderate-to-Severe Thyroid Eye Disease

NCT07265258Phase 4RecruitingPrimary

A Study of Teprotumumab N01 in Subjects With Active Thyroid Eye Disease

NCT06021054Phase 3CompletedPrimary

An Efficacy, Safety, and Tolerability Study of Veligrotug (VRDN-001), in Participants With Chronic Thyroid Eye Disease (TED)

NCT06106828Phase 3CompletedPrimary

A Study to Evaluate the Efficacy, Safety, Pharmacokinetics, and Pharmacodynamics of Satralizumab in Participants With Thyroid Eye Disease

NCT06401044Phase 1Active Not RecruitingPrimary

A Study of AMG 732 in Healthy Participants and Participants With Thyroid Eye Disease

NCT05987423Phase 3CompletedPrimary

Study to Evaluate the Efficacy, Safety, Pharmacokinetics, and Pharmacodynamics of Satralizumab in Participants With Thyroid Eye Disease

NCT07438405Phase 2RecruitingPrimary

An Open-label, Rollover Trial to Evaluate the Efficacy and Safety of AMG 732 in Participants With Thyroid Eye Disease

NCT07720648Phase 3Not Yet RecruitingPrimary

A Phase III Study of KHN939 in Chinese Patients With Moderate-to-Severe Inactive Thyroid Eye Disease

NCT07720635Phase 3Not Yet RecruitingPrimary

A Phase III Study of KHN939 in Chinese Patients With Moderate-to-Severe Active Thyroid Eye Disease

NCT07622368Phase 1RecruitingPrimary

A Study of IBI3031 in Participants With Thyroid Eye Disease

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