NCT05838898|Unknown
Specular Microscopy in Patients With Proliferative Diabetic Retinopathy
Changes of Corneal Endothelial Cells in Patients With PDR Using Specular Microscopy
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Changes of Corneal Endothelial Cells in Patients With PDR Using Specular Microscopy
Sponsor study identifier
observational
60
0 countries
N/A
Study Start
June 1, 2023
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
Primary Completion
January 1, 2025
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
Study Completion
June 1, 2025
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
.1. corneal endothelial profile in patients with proliferative diabetic retinopathy compared to a healthy age-matched control group. 2\. The effect of the age, and duration of Diabetes on the corneal endothelium .
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
June 1, 2025
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
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Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
September 9, 2022
Actual (reported)May 3, 2023
Actual (reported)June 1, 2023
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
January 1, 2025
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
June 1, 2025
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
To predict the effect of Diabetes on the cornea of diabetic patients
To evaluate corneal endothelial changes in patients with Proliferative diabetic retinopathy compared to normal group of the same age and gender using Specular microscopy
Baseline
Non-contact Specular microscopy is a non-invasive method that allows for in vivo study of corneal endothelium.
Registry-reported names are shown in full. Names without a link have not yet been matched to a Syfrah profile.
Image capture will be done by the same individual for all subjects. The following data will be collected and analyzed: corneal endothelial cell count, coefficient of variation, percentage of hexagonal cells and central corneal thickness.
Mortazavi SA, Akhlaghi M, Dehghani A, Pourazizi M, Malekahmadi M, Fazel M, Tavakoli M, Noorshargh P. Diabetic retinopathy and corneal endothelial parameters: an analytical cross-sectional study. BMC Ophthalmol. 2022 Nov 9;22(1):427. doi: 10.1186/s12886-022-02667-6.
Jha A, Verma A, Alagorie AR. Association of severity of diabetic retinopathy with corneal endothelial and thickness changes in patients with diabetes mellitus. Eye (Lond). 2022 Jun;36(6):1202-1208. doi: 10.1038/s41433-021-01606-x. Epub 2021 Jun 11.
First Submitted
September 9, 2022
First Posted
May 3, 2023
Study Start
June 1, 2023
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
Primary Completion
January 1, 2025
The Endothelial Count in Pxf
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This estimate has passed. The registry has not confirmed an actual date for this milestone.
Study Completion
June 1, 2025
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
Last Updated
May 3, 2023
Record last verified: 2023-04
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Source: ClinicalTrials.gov.
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