Endothelial Changes in Pseudoexfoliation Syndrome
PEX
Specular Microscopic Changes of Corneal Endothelial Cells After Phacoemulsification in Patients With Pseudo Exfoliation
1 other identifier
observational
100
0 countries
N/A
Brief Summary
this study aimed to evaluate the corneal endothelial cell changes before and after phacoemulsification in pseudoexfoliative patients relative to healthy adults.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P50-P75 for all trials
Started Feb 2022
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
January 4, 2022
CompletedFirst Posted
Study publicly available on registry
January 18, 2022
CompletedStudy Start
First participant enrolled
February 1, 2022
CompletedPrimary Completion
Last participant's last visit for primary outcome
February 1, 2023
CompletedStudy Completion
Last participant's last visit for all outcomes
March 1, 2023
CompletedJanuary 31, 2022
January 1, 2022
1 year
January 4, 2022
January 15, 2022
Conditions
Outcome Measures
Primary Outcomes (1)
Study of corneal endothelial changes in pseudoexfoliation syndrome
Comparison of corneal endothelial changes after phacoemulsification in patients with pseudoexfoliation and patient with cataract only
Baseline
Interventions
Phacoemulsification
Eligibility Criteria
This prospective, non-randomized comparative ,interventional study was performed on 100 eyes of 100 patients who were divided equally into two groups (pseudoexfoliative and control). Patient who aged above50 years and with nuclear cataract grade II,III, clear cornea and endothelial cell density more than 1000\\mm2 were included in this study. Also, patients with normal anterior chamber depth, dilatable pupil and with no active ocular disease or inflammation were included. Pseudoexfoliative patients who had glaucoma were excluded from the study.
You may qualify if:
- Patient age is above50 years.
- Patient with nuclear cataract grade II, III.
- Clear cornea with no evidence of endothelial disease.
- Endothelial cell density more than 1000\\mm2.
- Normal anterior chamber depth and dilatable pupil.
- No active ocular disease or inflammation.
- Pseudoexfoliative patients.
You may not qualify if:
- History of previous trauma, intraocular surgery or ocular surface infection in recent two weeks.
- Presence of any corneal opacity, endothelial disease, scarring or dystrophies.
- Pseudoexfoliative glaucoma.
- Patients age below 50 years.
- Endothelial cell count less than 1000\\mm2.
Contact the study team to confirm eligibility.
Sponsors & Collaborators
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Shymaa Sabet, Doctor
Assiut University
Central Study Contacts
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Principal Investigator
Study Record Dates
First Submitted
January 4, 2022
First Posted
January 18, 2022
Study Start
February 1, 2022
Primary Completion
February 1, 2023
Study Completion
March 1, 2023
Last Updated
January 31, 2022
Record last verified: 2022-01